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Popular Abstract in Swedish Mekanisk ventilation kan medföra "ventilationsinducerad lungskada" (VILI), som kan öka sjuklighet och dödlighet i samband med akut lungskada (ALI). Flera ventilationssätt har föreslagits för att undvika VILI, men inte slutgiltigt utvärderats. En princip är att öka alveolär ventilation och CO2-elimination genom att minska ventilationen av de skadliga rummet, dead space. Ventilator-induced lung injury (VILI) may contribute to morbidity and mortality of acute lung injury (ALI). Lung protective ventilation (LPV), that reduces VILI, may involve low tidal volume (Vt). Particularly low Vt is possible if dead space ventilation is reduced e.g. by aspiration of dead space gas (ASPIDS). ASPIDS implies that gas rich in CO2 during expiration is aspirated through a separate c

Popular Abstract in Swedish Den största källan till läkemedelsrester i vattenmiljön är utgående renat avloppsvatten från våra kommunala reningsverk. Läkemedel är utvecklade för att ha olika typer av biologiska effekter. Vilka dessa är i människan är relativt välkänt, medan effekterna på vattenlevande organismer och andra djur till stor del är okända. Detta i kombination med deras resistens mot de The discharge of effluents from wastewater treatment plants (WWTPs) is considered to be the major source of residual pharmaceuticals frequently found in aquatic environments. The complex nature of such compounds tends to make conventional biological treatments aimed at their removal ineffective. The present thesis concerns the removal of 62 different active pharmaceutical ingredients commonly dete

Pre-clinical heart transplantation studies have shown that ex vivo non-ischemic heart preservation (NIHP) can be safely used for 24 h. Here we perform a prospective, open-label, non-randomized phase II study comparing NIHP to static cold preservation (SCS), the current standard for adult heart transplantation. All adult recipients on waiting lists for heart transplantation were included in the stu

We challenge the currently dominating static view of inter‐industry relatedness by investigating the evolution of relatedness linkages between Swedish industries during five sub‐periods between 1991 and 2010. Distinguishing between stable ties (present in all sub‐periods) and non‐stable ties (e.g. emerging, disappearing, etc.), we demonstrate that inter‐industry relatedness linkages change conside

The Dalton Project provides a uniform platform access to the underlying full-fledged quantum chemistry codes Dalton and LSDalton as well as the PyFraME package for automatized fragmentation and parameterization of complex molecular environments. The platform is written in Python and defines a means for library communication and interaction. Intermediate data such as integrals are exposed to the pl

Aim The goal of this European Society of Coloproctology (ESCP) guideline project is to give an overview of the existing evidence on the management of diverticular disease, primarily as a guidance to surgeons. Methods The guideline was developed during several working phases including three voting rounds and one consensus meeting. The two project leads (JKS and EA) appointed by the ESCP guideline

Thoughtful use of simplifying assumptions is crucial to make systems biology models tractable while still representative of the underlying biology. A useful simplification can elucidate the core dynamics of a system. A poorly chosen assumption can, however, either render a model too complicated for making conclusions or it can prevent an otherwise accurate model from describing experimentally obse

This article analyzes administrative practices in relation to the emergence of novel technologies. “Smart mobility” is an umbrella term used to denote the potentially disruptive changes in the transport sector relating to automatization, digitalization, and the platform economy. While this development is largely driven by industry, public administrations are engaging in a number of processes where

Background: 18F-FDG PET/CT (FDG PET/CT) used in radiotherapy planning for extra-cerebral malignancy may reveal metastases to distant sites that may affect the choice of therapy. Aim: To investigate the role of FDG PET/CT on treatment strategy changes induced by the use of PET/CT as part of the radiotherapy planning. ‘A major change of treatment strategy’ was defined as either including more lesion

Introduction:The breath-hold technique inter alia has been suggested to mitigate the detrimental effect of motion on pencil beam scanned (PBS) proton therapy dose distributions. The aim of this study was to evaluate the robustness of incident proton beam angles to day-to-day anatomical variations in breath-hold.Materials and methods: Single field PBS plans at five degrees increments in the trans

Development of safe and efficient radiotherapy routines requires quantification of the delivered absorbed dose to the cancer tissue in individual patients. In vivo dosimetry can provide accurate information about the absorbed dose delivered during treatment. In the current study, a novel silver-nanosensor formulation based on poly(vinylpyrrolidinone)-coated silver nanoparticles formulated in a gel