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Deficient production of anti-viral interferons (IFNs) may be involved in causing viral-induced asthma exacerbations. Hence, drugs inducing lung IFN production would be warranted. Azithromycin may reduce asthma exacerbations but its modus operandi is unknown. Here, we investigated if azithromycin induces IFNβ expression in vitro in rhinovirus-infected bronchial epithelial cells from asthmatic donor

Aims: Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. Methods: Citizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population-based study. Ins

In 1736 Samuel Hesselius, former pastor for the Swedish parishes in Pennsylvania, donated a collection of ‘American curiosities’ to Lund University in Sweden. Within less than twenty years, however, the collection had apparently disappeared. In the course of the past three decades the lost ethnographic artefacts have received increasing attention, but for a variety of reasons the collection has re

Aims: The aim of the present study was to compare outcomes of endovascular surgery versus open vascular surgery in patients with diabetic foot ulcer (DFU) and peripheral arterial disease (PAD). Methods: Between 1984 and 2006, 1151 patients with DFU were admitted to the diabetic foot care team. Three hundred seventy-six patients with 408 limbs were consecutively included at a multidisciplinary foot

Purpose: Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low urine volume and high urine osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water

Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is

Background: One of the most serious secondary manifestations of Cardiovascular Disease (CVD) is coronary atherosclerosis. This study aimed to evaluate whether aged garlic extract (AGE) can influence coronary artery calcification (CAC) and to predict the individual effect of AGE using a standard process for data mining (CRISP-DM). Method: This was a single-center parallel randomized controlled stud

Chills and vomiting have traditionally been associated with severe bacterial infections and bacteremia. However, few modern studies have in a prospective way evaluated the association of these signs with bacteremia, which is the aim of this prospective, multicenter study. Patients presenting to the emergency department with at least one affected vital sign (increased respiratory rate, increased he

Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,

Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec

Denna uppsats analyserar Europeiska kommissionens förslag till en förord-ning om tvångslicenser i krissituationer. (COM(2023) 224) ur ett rättsligt och rättspolitiskt perspektiv. Förslaget syftar till att införa ett unionsomfattande system för tvångslicenser avsett att säkerställa tillgången till krisrelevanta pro-dukter, särskilt läkemedel, i situationer där nationella åtgärder bedöms vara otillrThis thesis examines the European Commission’s proposal for a regulation on compulsory licensing in crisis situations (COM(2023) 224) from a legal and legal-policy perspective. The proposal seeks to introduce a Union-wide sys-tem for compulsory licensing intended to ensure access to crisis-relevant products, particularly medicinal products, in situations where national measures are considered insu

In March of 2025, the Swedish Supreme Administrative Court decided to request a preliminary ruling in a case regarding repayment of Swedish withholding tax on dividends. The non-resident company claimed that they were not obligated to calculate their results according to Swedish rules, whereas the Swedish tax authority claimed that not doing so would make it impossible to determine whether the non

A spectrally and polarization-resolved wavefront detector can measure the spatio-temporal vector electric field of ultrashort laser pulses in a single shot.

The expansion of the electric vehicle industry is driving increased demand for lithium-ion batteries (LIBs), which in turn creates challenges in material availability and waste management that more durable LIBs could address. Electrode surface coating helps extend LIB lifespan, with atomic layered deposition (ALD) as the preferred method due to its precise thickness control and ability to coat var

The dispersion-scan technique (d-scan) is a well-established technique for the measurement of ultrashort laser pulses. While a single-shot version of d-scan is relatively easy to implement for sub-10 fs laser pulses, this becomes increasingly difficult as the pulse duration increases due to the need for a larger dispersion range, which scales quadratically with the Fourier transform limit (FTL). H

Insulin resistance (IR) contributes to atherogenic dyslipidemia and elevated ASCVD risk. Apolipoprotein A1 (ApoA1)-associated lipoproteins have diverse anti-atherogenic functions, but it is unclear whether IR drives adverse changes in their proteomic composition. We hypothesized that IR is associated with an atherogenic ApoA1 proteome and that insulin-sensitizing interventions would improve its co

Photonic topological insulators and self-induced nonreciprocity based on nonlinear effects in asymmetric structures have garnered increased attention due to their potential applications in quantum information technologies and advanced photonic integrated circuits. In this study, we combine these two fields and present asymmetric photonic crystal designs based on all-dielectric checkerboard structu

Studying photoluminescence (PL) is essential for understanding and engineering light-emitting nanomaterials. Heterogeneous samples, such as thin films and microstructures, require characterization of the spatial distribution of PL intensity, spectra, lifetimes, and photon correlations at the microscale under variable temperatures. Here we describe a cryo-optical setup for micro-PL imaging, spec

Editorial for the special issue of "Small Structures"