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Amyloid fibrils have been implicated in the pathogenesis of several neurodegenerative diseases, the most prevalent example being Alzheimer's disease (AD). Despite the prevalence of AD, relatively little is known about the structure of the associated amyloid fibrils. This has motivated our studies of fibril structures, extended here to the familial Arctic mutant of Aβ1-42, E22G-Aβ1-42. We found E22
Micron-sized aluminum (Al) particles have recently been proposed as promising carbon-free energy carriers. To facilitate the application of micron-sized Al particles as fuel in practical energy generation system, this study experimentally investigates the underlying mechanisms of the ignition, stabilization and particle-particle collision in lifted Al particle cloud flames. High-resolution shadowg
Cushioned lipid bilayers are structures consisting of a lipid bilayer supported on a solid substrate with an intervening layer of soft material. They offer possibilities for studying the behavior and interactions of biological membranes more accurately under physiological conditions. In this work, we continue our studies of cushion formation induced by histatin 5 (24Hst5), focusing on the effect o
This literature review presents a summary of recent research about PM-less machines for electrical vehicles. Recently, IPM machines has proven to be very popular among electrical vehicle manufacturers. However, the neodymium permanent magnets being used are expensive and have a risk of rocketing the production cost of a machine if the price increases more. With this in mind, five PM-less machine t
Oligomeric species arising during the aggregation of α-synuclein are implicated as a major source of toxicity in Parkinson’s disease, and thus a major potential drug target. However, both their mechanism of formation and role in aggregation are largely unresolved. Here we show that, at physiological pH and in the absence of lipid membranes, α-synuclein aggregates form by secondary nucleation,
Functional amyloids formed by the protein FapC in Pseudomonas bacteria are key structural components of Pseudomonas biofilms, which mediate chronic infections and also contribute to antimicrobial resistance. Here, we combine kinetic experiments with mechanistic modelling to probe the role of surfaces in FapC functional amyloid formation. We find that nucleation of new fibrils is predominantly hete
Objective: To investigate the feasibility of using neutron tomography to gain new knowledge of human articular cartilage degeneration in osteoarthritis (OA). Different sample preparation techniques were evaluated to identify maximum intra-tissue contrast. Design: Human articular cartilage samples from 14 deceased donors (18–75 years, 9 males, 5 females) and 4 patients undergoing total knee replace
Introduction: Information about autonomic nervous system (ANS) activity may offer insights about atrial fibrillation (AF) progression and support personalized AF treatment but is not easily accessible from the ECG. In this study, we propose a new approach for ECG-based assessment of respiratory modulation in atrioventricular (AV) nodal refractory period and conduction delay. Methods: A 1-dimension
Nu för tiden använder människor världen över, medvetet eller omedvetet, molntjänster, där stora mängder personlig information placeras och lagras. Personuppgifter är en av de mest värdefulla tillgångar ett företag kan inneha, och således utnyttjar företag runt om i världen sådan personlig information för kommersiella syften. Samtidigt har statliga myndigheters övervakning av personer och insamlingToday, people all around the world, consciously or unconsciously, use services provided by cloud computing where large amounts of personal data is placed and stored. Personal data is one of the most valuable assets a company can hold, and therefore companies utilise such data for commercial purposes. At the same time, the surveillance powers and the collection of personal data have increased among
Climate-focused study abroad relying on high-emitting travel poses a dilemma between study abroad and emission reductions. This study employs the three spheres of transformation investigating this dilemma through coding syllabi (n=156,) surveying educators (n=9,) and interviewing (n=14) Climate Action Network for International Educators (CANIE) affiliates considering whether studying climate chang
Enterprise Resource Planning (ERP) systems have been used by organizations and companies throughout the world since 1990. Many universities have recently replaced their legacy systems with ERP systems to improve work efficiency. One solution available for universities by way of management information system is the Campus ERP system. The Campus ERP system helps universities incorporate all departme
I juli 2016 introducerades lagen om tillfälliga begränsningar av möjligheten att få uppehållstillstånd i Sverige (den tillfälliga lagen). Ikraftträdandet av den tillfälliga lagen innebar att rätten till familjeåterförening för alternativt skyddsbehövande begränsades avsevärt. Enligt 7§ den tillfälliga lagen exkluderades alternativt skyddsbehövande från rätten att återförenas med sin familj under dIn July 2016, the Law on temporary limitations to the possibility of being granted residence permit in Sweden (the Temporary Law) came into force. The Temporary Law implied a sharp turn in Swedish asylum legislation. The right to family reunification, which previously had been granted subsidiary protection beneficiaries and refugees on a similar basis, was suddenly heavily restricted for beneficia
Åldrandet hos oss människor är individuellt och sker gradvis under en lång tid. Vissa funktioner i kroppen försämras och äldre människor har ofta av olika anledningar svårigheter att få i sig den mängd näring som de har ett behov utav, därför behöver de oftast dela upp sin kost i fler måltider fördelat under dagen. I denna uppsats jämförs kosten som serveras i ett ålderdomshem i en mindre kommun iThe aging of us humans is individual and occurs gradually over a long period of time. Some functions in the body deteriorate and older people often have difficulty for various reasons to get the amount of nutrition they need, so they usually need to divide their diet into more meals distributed during the day. In this essay, the diet served in a retirement home in a small municipality in northwest
Sverige är ett av få länder som har tagit fram en nationell handlingsplan för att omsätta FN:s vägledande principer för företag och mänskliga rättigheter på nationell nivå. FN:s vägledande principer skapar inga nya folkrättsliga förpliktelser, utan uppmuntrar endast stater att ta fram nationella handlingsplaner för att omsätta principerna på nationell nivå. Sveriges framtagande av planen kan såled
Kycklingkött är det kött med minst klimatpåverkan och fjäderfän, Gallus gallus, är den djurart som det föds upp flest av i världen. I Sverige ökar antalet fjäderfä samtidigt som den genomsnittliga besättningsstorleken ökar. Det är mer väsentligt än någonsin att hönsen som vi använder inom livsmedelsproduktionen mår bra och har en hög djurvälfärd. Synen är det sinnet som fåglarna använder mest och Factory produced chicken meat has the lowest climate impact and domesticated poultry, (Gallus gallus), is the world's most commonly bred animal. In Sweden the production of poultry is increasing, also the size of an average facility with chickens is increasing. Vision is their dominant sense organ and the vision is important for the animals to be able to explore their environment and search fo
Significant behavioral changes will need to be implemented to prevent the energy supply sector from tripling CO2 emissions by the midcentury. However, within the academic research, behavior changes remain primarily focused on the individual level, while the behavior of companies that are responsible for elevated greenhouse gas emissions falls behind. This master’s thesis analyses the core values
Syftet med denna studie är att nå nya kunskaper gällande värdering av ämnet musik, sett utifrån olika infallsvinklar. Studien syftar även till att belysa musikens påverkan på en skolmiljö och att understryka musikens värde i skolan. Studien utfördes vid en norsk grundskola i Spanien och bygger på kvalitativa intervjuer av fokusgrupper bestående av elever från olika årskurser, samt intervjuer med mThe purpose of this study is to obtain new knowledge on the perceived and given value of the subject music from different points of views. The study also intends to investigate the effect of music on a school environment and to examine its value in school. The study was made at a Norwegian school in Spain and it is based on qualitative interviews with focus groups including students from different
Syria, as well as many other countries in the Middle East, faces serious water shortage problems. Available water per capita (AWPC) will dramatically decrease due to climate change, population increase, and water needed for economic growth. Rainwater harvesting can play an important role in increasing available water in Syria. However, the absence of rainwater sewer systems in many rural areas in
