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The flexibility demands in manufacturing are severe, e.g., for rapid-change-over to new product variants, while robots are flexible machines that potentially can be adapted to a large variety of production tasks. Task definitions such as explicit robot programs are hardly reusable from an application point-of-view. To improve the situation, a knowledge-based approach exploiting distributed declara
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroid defect remain elusive. Previous studies have indicated that activation of p53
Background: High fasting plasma proneurotensin concentration was associated with the development of breast cancer in the Malmö Diet and Cancer Study (MDCS). Here we aimed at replicating the initial finding in an independent second cohort. Methods: The Malmö Preventive Project (MPP) is a population study and comprised 18 240 subjects when examined 2002-2006. Of women without history of breast cance
The transcription factor STAT3 is constitutively active in several malignancies including castration-resistant prostate cancer and has been identified as a promising therapeutic target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth, both in vitro and in vivo, of prostate cancer cells expressing active STAT3 and induces apoptosis of prostate cancer stem cel
Trends towards distributed power generation and the deregulation of energy markets are increasing the requirement for software tools that optimize power generation plant design and operation. In this context, this paper describes the GTPOM (thermo-economic optimization of whole gas turbine plant) European project, funded in part through the European Commissions 5th Framework Programme, focusing on
Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activi
The synthesis and characterization of phthalocyaninato-ruthenium (PcRu) complexes with potential functional axial ligands are described. The solubility of these PcRu complexes was much improved compared to their parent phthalocyanines without Ru, enabling purification by normal flash column chromatography and also NMR measurements in common solvents (e. g. DMSO-d(6) and CDCl3). Adsorption of these
A unified approach is presented for establishing exact integration of the constitutive equations in elastoplasticity, assuming the total strain-rate direction to be constant. This unified approach includes all previous exact integration procedures as special cases and, in addition, some new closed-form solutions are derived for combined kinematic and isotropic hardening. Special emphasis is laid o
The aim of the study was to determine how significance indicators assigned to different Web page elements (internal metadata, title, headings, and main text) influence automated classification. The data collection that was used comprised 1000 Web pages in engineering, to which Engineering Information classes had been manually assigned. The significance indicators were derived using several differe
The Wilms tumor gene, WT1, encodes a zinc-finger DNA binding protein which is thought to function as a tissue specific transcription factor, regulating cell growth and differentiation. High expression of WT1 has been detected in a range of acute leukemias. To elucidate a role for WT1 in leukemogenesis, we transfected the monoblastic cell line U937, which lacks detectable levels of endogenous WT1,
Integrated models are inherently complex and often obscure to any but those who write them. Their usefulness can be greatly enhanced through well-structured, object-oriented design. A robust and computationally efficient Simulink/C++ library of optics, control, finite-element, and visualization routines for modeling radio telescope performance under various operating conditions is being developed
Latency is a fundamental problem for all distributed systems including digital libraries. To reduce user perceived delays both caching-keeping accessed objects for future use-and prefetching-transferring objects ahead of access time-can be used. In a previous paper we have reported that caching is not worthwhile for digital libraries due to low re-access frequencies. In this paper we evaluate our
The Euro50 is a proposed optical telescope with an equivalent aperture of 50 m. It will have a segmented primary mirror and full adaptive optics. To study the interaction of the telescope structure, the control system and the optics, an integrated simulation model has been formulated. The mechanical model is a modal version of an Ansys finite element model. The optics model is based on ray tracing
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator Lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood derived CD34+ cells and promotes in vitro propagation of long-term repopulating HSCs by preventing differentiation. The phenot
