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Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepress

Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pa

Summary - Nefab The purpose of this thesis is to find business opportunities in South Africa for Nefab's product NEFAB ExPak, The product is suitable for packaging of high-value products that are being exported to remote countries. Besides a general mapping of South Africa's export, we have also studied different companies within the vehicle supply industry, telecommunication industry

The purpose of this study is to show which possibilities the railways in the western part of Småland can offer to the inhabitants and industry within the region. The background is that the passenger traffic is suffering from unprofitability because of bad infrastructure standard, long journey times and low traffic density. The railway between Halmstad and Nässjö was completed 1882, and the branch

Uppsatsen behandlar frågan om positiv särbehandling på grund av kön och etnicitet i det svenska arbetslivet. Ett sätt att motverka missförhållanden på den svenska arbetsmarknaden har varit införandet av positiv särbehandling. Positiv särbehandling är ett undantag från likabehandlingsprincipen och syftar till att åstadkomma reell jämlikhet. Positiv särbehandling tillåts i svensk rätt för att åstadk

The subject of our master’s thesis is museum exhibitions for children. The thesis is based on three research questions: “What purposes do institutions have when they decide to produce museum exhibitions specifically for children?”, “What are the similarities and differences concerning the intermediation techniques, voice and intent in this type of exhibitions?” and “How does the underlying intenti

The purpose of this thesis has been to study different dimensions of work and the political ”work-first” principal within strategies of social inclusion. The primary material of the analysis consists of two relevant and current documents concerning the strategy ”A coordinated and longterm strategy of roma inclusion 2012-2032” (author’s translation) of the Swedish government. I have applied two the

Sammanfattning Examensarbetets titel: Estimering av illikviditetsrabatter Seminariedatum: 2011-06-03 Ämne/kurs: FEKK01, Examensarbete kandidatnivå, 15 Hp Författare: Robert Johansson och Harald Karlsson Handledare: Tore Eriksson Nyckelord: Alternativa Aktiemarknaden, Aktietorget, OMX Small Cap, Illikviditetsrabatter, likviditet, illikviditet Syfte: Syftet är att undersöka i vilken mån illikviditet

Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on redu

Electrostatic interactions play crucial roles in protein function. Measuring pKa value perturbations upon complex formation or self-assembly of e.g. amyloid fibrils gives valuable information about the effect of electrostatic interactions in those processes. Site-specific pKa value determination by solution NMR spectroscopy is challenged by the high molecular weight of amyloid fibrils. Here we rep

Around 20 % of all electrical energy goes to lighting. There is a strong need to make this figure lower. Our research group has for more than a decade worked with the problem how to reduce the energy use for lighting, but at the same time provide better lighting conditions to meet human needs. The work comprises both laboratory studies and field studies. Two different tracks have been used: One th

Background: Data regarding the impact of preheart failure (HF) comorbidities on the prognosis of HF are scarce, especially in the younger HF patients. Objectives: To investigate pre-existing comorbidities in HF patients versus matched controls and to assess their impact on mortality. Methods: We included all first-time in-hospital and outpatient diagnoses of HF from 1995 to 2017, and comorbidities

Fuel and load flexibility have been increasingly important features of industrial gas turbines in order to meet the demand for increased utilization of renewable fuels and to provide a way to balance the grid fluctuations due to the unsteady supply of wind and solar power. Experimental investigations were performed using a standard 3rd generation dry low emission (DLE) burner under atmospheric pre

Background and Purpose - Aortic valve stenosis may lead to atrial and ventricular remodeling, predisposes to atrial fibrillation, and may also be an independent risk factor of ischemic stroke. However, information on stroke rates among persons with aortic valve stenosis are sparse. We aimed to determine the incidence rates and relative risks of ischemic stroke in individuals with diagnosed aortic

There is an unmet clinical need to extract living circulating tumor cells (CTCs) for functional studies and in vitro expansion to enable drug testing and predict responses to therapy in metastatic cancer. Here, we present a novel two-step acoustophoresis (A2) method for isolation of unfixed, viable cancer cells from red blood cell (RBC) lysed whole blood. The A2 method uses an initial acoustofluid

Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and magnitude of the putative causal pathways linking dysglycemia and fatty liver, using a combination of causal inference methods.Measures of glycemia, insulin dynam

High-dose methotrexate (HDMTX) is a central component in the treatment of acute lymphoblastic leukemia, osteosarcoma, and some lymphomas and brain tumors. MTX is given at lethal doses and then is followed by rescue treatment with folinic acid (FA). Despite FA rescue, many patients suffer severe toxicity. The pharmacokinetics of FA rescue have not been sufficiently studied. However, optimization of