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Background: Traditional risk factors for atherosclerotic disease (AD) are well-known, of which some are relevant also for abdominal aortic aneurysms (AAA). The present study compares the importance of plasma biomarkers and traditional risk factor profiles for incident AD without concomitant AAA (isolated AD) and AAA without concomitant AD (isolated AAA) during long-term follow-up. Methods: In the

Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African,

It is shown that the isoscalar strength in the energy region just above the low energy threshold, which is created by exciting particles to the continuum in nuclei far from β-stability lines, can be reduced by the attractive coupling to isoscalar shape oscillations. This is in contrast to the well known fact that in β-stable nuclei low lying isoscalar particle hole strengths are always increased b

Popular Abstract in Swedish Olika former av ljus har använts i åtminstone 5000 år i medicinska sammanhang. Man har i många tidiga kulturer använt solljus för att behandla olika sjukdomar. Under det senaste århundradet har användandet av ljus introducerats i den västerländska medicinen. Nya former av ljusterapi har införts. Med utvecklingen av lasern på 1960-talet dök nya användningsområden upp. LaSome aspects on the use of light for tissue characterization and treatment of malignant tumours are discussed within this thesis. The work presented aims at improving optical techniques for tissue characterization, especially to detect malignant and pre-malignant lesions. A knowledge on the interaction between light and tissue is of utmost importance to understand and improve the various technique

The aim of this quantitative study was to follow up children born extremely preterm (before week 29) in adulthood. The group of extremely preterm adults was compared to peers born at term. The extremely preterm and the control group have previously been followed up at ages 10 and 18. At the time of this study the participants were 27-28 years old. Questionnaires were sent to the two groups and 77

This study focuses on the intrinsically disordered regulatory domain of p53 and the impact of post-translational modifications. Through fully atomistic explicit water molecular dynamics simulations, we show the wealth of information and detailed understanding that can be obtained by varying the number of phosphorylated amino acids and implementing a restriction in the conformational entropy of the

Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. Here, a combined single-cell immunopheno

α-Synuclein is an intrinsically disordered presynaptic protein associated with Parkinson's disease. The physiological role of α-Synuclein is not fully understood, but the protein is known to interact with lipid membranes. We here study how membrane charge affects the adsorption of α-Synuclein to (i) supported lipid bilayers and (ii) small unilamellar vesicles with varying amounts of anionic lipids

Heart failure (HF) is a leading cause of death and disability globally. Heritable factors and the extent and pattern of myocardial fibrosis are important determinants of outcomes in patients with HF. In a genome-wide association study of mortality in HF, we recently identified a genetic polymorphism on chromosome 5q22 associated with HF mortality. Here, we sought to study the mechanisms by which t

Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-indepen

Recenserad bok: Kurator inom hälso- och sjukvård (upplaga 3)Författare: Annika Lundin, Inger Benkel, Gerd de Neergaard, Britt-MarieJohansson och Charlotta ÖhrlingFörlag: Studentlitteratur, Lund, 2019

In2O3-based catalysts have shown high activity and selectivity for CO2 hydrogenation to methanol; however, the origin of the high performance of In2O3 is still unclear. To elucidate the initial steps of CO2 hydrogenation over In2O3, we have combined X-ray photoelectron spectroscopy and density functional theory calculations to study the adsorption of CO2 on the In2O3(111) crystalline surface with

Background Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) plasma levels are associated with increased risk for venous thromboembolism (VTE). Objectives This study aimed to determine the thrombotic risk of rare and common variants of 27 genes linked to VWF or FVIII plasma levels in genome-wide association studies. Methods Exon sequences of 27 genes linked to plasma levels of VWF or

Background. The estimation of glomerular filtration rate (GFR) is one tool to detect renal disease. The most used biomarker remains serum creatinine and the European Kidney Function Consortium (EKFCcrea ) equation is the most validated in Europe. More recently, cystatin C has been proposed as a biomarker. We studied the performances of the EKFC equations in a large cohort of subjects according to

Objectives: To evaluate the feasibility of AI-assisted reading of prostate magnetic resonance imaging (MRI) in Organized Prostate cancer Testing (OPT). Methods: Retrospective cohort study including 57 men with elevated prostate-specific antigen (PSA) levels ≥3 µg/L that performed bi-parametric MRI in OPT. The results of a CE-marked deep learning (DL) algorithm for prostate MRI lesion detection wer

Introduction: Discordant results between cystatin C and creatinine in estimating glomerular filtration rate (GFR) are an important medical issue. However, the equation that should be used when GFR estimates are discordant remains unclear. Methods: This cross-sectional analysis included 15,485 participants with GFR measured by the clearance of an exogenous marker, serum creatinine, and cystatin C.

The human influence on Earth's ecosystems is omnipresent. Artificial light at night (ALAN), anthropogenic noise, and air pollution are inherent features of human activities and infrastructure and pose novel environmental challenges to urban-dwelling wildlife. So far, most of the studies investigating the impacts of exposure to urban pollutants on animals have either investigated the effects of urb

Microsoft Word - General study plan_Medical Science, doctoral degree.doc Research Studies Board GENERAL STUDY PLAN FOR DOCTORAL STUDIES IN MEDICAL SCIENCE Scope: 240 credits Qualification: Degree of Doctor Details of approval: Approved by the Research Studies Board on 11 June 2018 Applies from: 1 January 2019 Amended: 10 December 2018 This is a translation of the Swedish version. In the event of a

https://www.intramed.lu.se/en/sites/intramed.lu.se.en/files/2023-06/General%20study%20plan_Medical%20Science,%20doctoral%20degree%20(1).pdf - 2026-06-01

Professorsinstallation Lunds universitet | auLan | 7 september 2012 kL 16.00 3 Förord Välkomna till den högtidliga professorsinstallationen! Ordet universitet kommer av det latinska universitas, som betyder ungefär helhet, det hela. Detta ord har samband med universus med betydelsen hel, allomfat- tande, egentligen vänd åt ett håll liksom med universum och universell. Universitas blev under högmed

https://www.lu.se/sites/www.lu.se/files/professorsinstallationsbroschyr_sep2012.pdf - 2026-06-01