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Warrants in Pauline Argumentation

Religious argumentation is sometimes supposed to be different from other kinds of argumentation. George Kennedy for example mentions a radical Christian rhetoric in which the message is proclaimed rather than argued, but in my study of Paul’s first letter to the Corinthians I have found deliberate argumentation. This argumentation can be analyzed with Toulmin’s model of argumentation. The warrants

Towards a framework for holistic contextual design for low-resource settings

Healthcare inequality is ubiquitous globally, but the effects are most striking in low-resource settings. In these settings, current methods for the design of medical devices are failing to address specific needs. The associated publications rarely describe how the context was studied at the front-end of design. There is a latent need for a holistic contextual framework for guiding the design deci

Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient

The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observ

On compositions of special cases of Lipschitz continuous operators

Many iterative optimization algorithms involve compositions of special cases of Lipschitz continuous operators, namely firmly nonexpansive, averaged, and nonexpansive operators. The structure and properties of the compositions are of particular importance in the proofs of convergence of such algorithms. In this paper, we systematically study the compositions of further special cases of Lipschitz c

MSLibrarian: Optimized Predicted Spectral Libraries for Data-Independent Acquisition Proteomics

Data-independent acquisition-mass spectrometry (DIA-MS) is the method of choice for deep, consistent, and accurate single-shot profiling in bottom-up proteomics. While classic workflows for targeted quantification from DIA-MS data require auxiliary data-dependent acquisition (DDA) MS analysis of subject samples to derive prior-knowledge spectral libraries, library-free approaches based on in silic

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of AML patients, but not on normal hematopoietic stem cell

Front-end electronics and readout system for the ILD TPC

A high resolution TPC is the main option for a central tracking detector at the future International Linear Collider (ILC). It is planned that the MPGD (Micro Pattern Gas Detector) technology will be used for the readout. A Large Prototype TPC at DESY has been used to test the performance of MPGDs in an electron beam of energies up to 6 GeV. The first step in the technology development was to demo

Large-scale Feature Evolution: Problems and Solutions from the Mobile Domain

Abstract in UndeterminedYou may think that your requirements engineering process is fairly limited and currently not too complex to manage. Or you may be right in the middle of a storm of requirements where it is impossible to manage even the most important ones comprehensively. If you are in the former situation, it may be dangerous to relax as many successful software-intensive products have a t

Telomerase activation as a possible mechanism of action for psychopharmacological interventions.

Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychot

Analytical solutions to two- and three-dimensional periodic flows for numerical model testing

Analytical solutions to 2D depth-averaged (external mode) and fully 3D (internal mode) periodic flows for numerical model testing are presented in this paper. These solutions take into account the effects of the bottom friction, the horizontal turbulent viscosity, and the vertical turbulent viscosity for the case of 3D flow. The key linkage for the modes is the relationship between the bottom fric

Extracting high fidelity quantum computer hardware from random systems

An overview of current status and prospects of the development of quantum computer hardware based on inorganic crystals doped with rare-earth ions are presented. Major parts of the experimental work in this area have been done in two places, Canberra, Australia and Lund, Sweden, and the present description follows more closely the Lund work. Techniques will be described that include optimal filter