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AimTreatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the efficacy of bioactive platelet-rich fibrin matrix in treating complex anal fistulae.MethodThis retrospective study analysed data from 2019 to 2022 of patients diagnos
A search for the dimuon decay of the Higgs boson is presented based on pp collision data recorded by ATLAS during Run 3 of the Large Hadron Collider, corresponding to an integrated luminosity of 165 fb-1 at √s = 13.6 TeV. To enhance the sensitivity, the results are combined with those from Run 2. An excess of events over the background is observed with a significance of 3.4σ (2.5σ expected). The b
Extreme heat is a growing public health threat in tropical Africa, especially in Ghana where outdoor maximum daily temperatures (Tx) regularly exceed 35 °C. Vulnerability to heat is socially and economically differentiated, with pregnant women, young children, elderly people, and people with chronic health conditions most at risk. High proportions of these groups are found in hospitals, yet little
This paper explores the changing nature of social institutions and organizations for resource management on Ontong Java and their central role in maintaining livelihoods. Using detailed field data for three time periods, 1970-72, 1986 and 2006-07, and drawing on earlier secondary data, a longitudinal analysis of changes in governance and livelihoods is undertaken. Increased exploitation of marine
Water balance models provide insights into ongoing changes in the water cycle. Among them, monthly water balance models (MWBMs) are especially suitable for large-sample and global assessments, which are important for adaptation to global environmental change. This study evaluates monthly water balances from 14 models across more than 2,000 global catchments, comparing the modelś capacities to repr
This chapter discusses trade-offs that need to be struck while developing Unmanned Aircraft Systems (UAS) operations. Ten trade-offs are outlined, pertaining to technical systems, to human operators, and to the combined sociotechnical system in its operational and organizational environment, which have implications for Human-Systems Integration (HSI) in multiple phases of the systems engineering l
OBJECTIVES: To identify the lowest sensitivity and specificity that physicians and the general population consider acceptable for medical artificial intelligence (AI), relative to current human performance.METHODS: In a nationwide, cross-sectional survey in Sweden, 2025, random samples of 500 physicians and 500 adults from the general population were mailed a questionnaire presenting three vignett
The resilience performance of networked microgrids (NMGs) in disaster-prone areas, using a real-world testbed located in Lombok, Indonesia is explored in this paper. Given the increasing environmental pressures and energy security concerns in Indonesia, it is vital to improve the robustness and sustainability of decentralized energy infrastructures. We propose an optimization-based energy manageme
This study clarifies when Bayesian analysis provides a practical advantage, particularly in large-area searches, hazardous or inaccessible environments, and low signal-to-noise ratio (SNR) scenarios where direct source approach is not feasible. We present a PyMC-based Bayesian framework for localizing a single unshielded gamma-emitting source and estimating its activity, with the ability to switch
Notch connections are commonly used in timber concrete composite (TCC) members because of the simple geometry of the solution making execution easy and the high strength and stiffness resulting from the mechanical interlock between the timber and concrete. However, the use of low strength lightweight concrete in TCC applications is limited in the literature. Therefore, in this work, shear tests we
The fields of cultural tourism and heritage management are gaining attention for their potential to be better linked, particularly in terms of practical applications. This paper proposes a taxonomy of heritage resources and related heritage-based tourism types and their linkages for specific case study areas, building on the established product class approach in cultural tourism studies. The resea
Introduction: Cervical cancer represents a significant public health challenge worldwide. To improve screening accessibility and participation, we implemented vaginal human papilloma virus (HPV) self-sampling as part of an organized cervical cancer prevention strategy. This study aimed to evaluate the implementation and outcomes of the self-sampling program in a real-world setting. Material and Me
Human pluripotent stem cell-derived in vitro models, combined with advances in high-content live-cell calcium imaging, provide a powerful platform for disease modeling and drug screening. However, most calcium imaging analysis tools have been developed for in vivo applications with suboptimal features for processing data from cultured neurons. Here, we present LUMIN (Live-cell User Module for Imag
Al-Ga-based alloys are promising carriers of renewable energy, which can provide hydrogen by hydrolysis in challenging working environments. Manipulating their performance by different process conditions and comprehending the mechanisms are important for achieving directional design synthesis of alloys and enhancing their practicality. This study presents a novel approach to optimizing the hydroge
A high-resolution integrated bio-chemostratigraphic framework is established for the upper Tremadocian to lower Floian (Lower Ordovician) succession of the North China Block, based on new conodont and carbon isotope (δ13Ccarb) data from the Jiguanshan and Wudingshan sections in Liaoning Province, northeastern China. Thirty conodont species of 19 genera were identified from the two sections. Based
A quantitative understanding of the hydro-environmental factors that influence the occurrence of agricultural drought events would enable more strategic climate change adaptation and drought management plans. Practical drought hazard mapping remains challenging due to possible exclusion of the most pertinent drought drivers, and to the use of inadequate predictive models that cannot describe droug
PurposeThis study aims to investigate how stakeholder cocreation in 3D city mapping initiatives can extend the role of digital urban platforms beyond administrative efficiency toward the negotiation and enhancement of place attractiveness. Drawing on a participatory case study of Trollhättan, Sweden, the paper explores the needs, expectations and aspirations articulated by diverse stakeholder grou
