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To meet climate targets, a global shift away from fossil fuels is essential. For sectors where electrification is impractical, it is crucial to find sustainable energy carriers. Renewable methanol is widely considered a promising fuel for powering heavy-duty applications like shipping, freight transport, agriculture, and industrial machines due to its various sustainable production methods. While
GTP hydrolysis is a biologically crucial reaction, being involved in regulating almost all cellular processes. As a result, the enzymes that catalyze this reaction are among the most important drug targets. Despite their vital importance and decades of substantial research effort, the fundamental mechanism of enzyme-catalyzed GTP hydrolysis by GTPases remains highly controversial. Specifically, ho
Recent years have seen tremendous effort in the development of approaches with which to obtain quantum mechanics/molecular mechanics (QM/MM) free energies for reactions in the condensed phase. Nevertheless, there remain significant challenges to address, particularly, the high computational cost involved in performing proper configurational sampling and, in particular, in obtaining ab initio QM/MM
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of methylxanthines in preventing or treating intermittent hypoxemia or respiratory insufficiency in late preterm infants.
In this paper, we present a multipath-based simultaneous localization and mapping (SLAM) algorithm that con-tinuously adapts mulitiple map feature (MF) models describing specularly reflected multi path components (MPCs) from flat surfaces and point-scattered MPCs, respectively. We develop a Bayesian model for sequential detection and estimation of interacting MF model parameters, MF states and mob
Parkinson's disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is an effective and well-Tolerated dopamine replacement agent. However, levodopa provides only symptomatic improvements, without affecting the underlying pathology, and is associated with side effects after long-Term use. Cel
Acceptance and Commitment Therapy (ACT) has been widely tested for chronic pain, with demonstrated efficacy. Nevertheless, although there is meta-analytical evidence on the efficacy of face-to-face ACT, no reviews have been performed on online ACT in this population. The aim of this meta-analysis is to determine the efficacy of online ACT for adults with chronic pain, when compared with controls.
Satisfying the mobile traffic demand in next generation cellular networks increases the cost of energy supply. Renewable energy sources are a promising solution to power base stations in a self-sufficient and cost-effective manner. This paper presents an optimal method for designing a photovoltaic (PV)-battery system to supply base stations in cellular networks. A systematic approach is proposed f
As an emerging country, Vietnam needs competent business entrepreneurs who are expected to modernize the economy, renew business and management practices, and develop sustainable growth strategies. The mission of business and management education, thus, is to prepare graduate students for the development of transitional Vietnam and future global challenges. Graduates’ competency, according to comp
IntroductionEmerging evidence suggests a difference in access to facilities for medical termination of pregnancy (MTP) and delivery among women in different regions of the country. However, we lack assessments at a large scale across all geographies. Our study aims to describe the percent contribution of private and public sectors in institutional deliveries and MTP in India.MethodsA secondary dat
Background: Due to a large variety in treatment outcomes reported in therapeutic trials and lacking patient-relevant outcomes, it is hard to adequately compare and improve current therapies for patients with capillary malformations (CMs). The Core Outcome Set for Capillary Malformations (COSCAM) project aims to develop a core outcome set (COS) for use in future CM trials, in which we will first de
Transfusion of ABO major incompatible platelets (where the recipient has antibodies against the ABO group of the transfused platelets) has been shown to be associated with lower platelet count increments following transfusion [1], although this does not appear to translate to a difference in bleeding outcomes [2]. Transfusion of minor ABO incompatible platelets (where the suspending plasma of the
Secondary mitral regurgitation (MR) occurs despite structurally normal valve apparatus due to an underlying disease of the myocardium leading to disruption of the balance between tethering and closing forces with ensuing failure of leaflet coaptation. In patients with heart failure (HF) and left ventricular dysfunction, secondary MR is independently associated with poor outcome, yet prognostic ben
Light stability of different spray dried microencapsulated powders containing the natural colorant bixin was evaluated for 30 days. The encapsulating materials evaluated were sucrose, maltodextrin, and mixtures including gum arabic and pectin as encapsulation enhancers. The photostability of two sets of encapsulated material was compared: one containing purified bixin, and one being an annatto ext
BACKGROUND: The current study explores predictors and moderators of pediatric PTSD outcomes for Eye Movement Desensitization and Reprocessing Therapy (EMDR) and Cognitive Behavioral Writing Therapy (CBWT). METHODS: Data were obtained as part of a multi-center randomized controlled trial of up to six sessions (up to 45 minutes each) of either EMDR therapy, CBWT, or wait-list, involving 101 youth (a
Background: A community-based intervention was implemented to improve maternal, child, and adolescent health practices, promote financial literacy and enhance livelihood opportunities for young people in marginalized communities. A hypothesis related to our intervention was that peer-led education sessions on health and nutrition in conjunction with community mobilization would change communities'
Soil cation exchange capacity (CEC) strongly influences the chemical, physical, and biological properties of soil. As the direct measurement of the CEC is difficult, costly, and time-consuming, the indirect estimation of CEC from chemical and physical parameters has been considered as an alternative method by researchers. Accordingly, in this study, a new hybrid model using a support vector machin
