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Rules and Tools in the Battle against Superbugs - A call for integrated strategies and enhanced international collaboration to promote antimicrobial drug development

The lack of treatments during the recent Ebola and Zika outbreaks dramatically exposed the vulnerability of the global health system and the dire consequences thereof. But even where therapies against infectious diseases had been available, an additional threat has gained world-wide attention: antimicrobial resistance (AMR). A growing number of microbial organisms are becoming resistant to availab

Coronary Angiography and Intervention in Women Resuscitated From Sudden Cardiac Death

Background Coronary artery disease is the primary etiology for sudden cardiac arrest in adults, but potential differences in the incidence and utility of invasive coronary testing between resuscitated men and women have not been extensively evaluated. Our aim was to characterize angiographic similarities and differences between men and women after cardiac arrest. Methods and Results Data from the

Populism, Exceptionality and the Right of Migrants to Family Life Under the European Convention on Human Rights

The populist turn in national and international politics includes one common question across countries: curbing immigration and limiting the rights of migrants. In the light of these restrictive tendencies, the questions that this article seeks to address are: whether and how the European Convention on Human Rights (ECHR), as interpreted by the European Court of Human Rights (ECtHR), can be a poin

Implementation of the integrated palliative care outcome scale in acute care settings - a feasibility study

OBJECTIVE: Although hospitals have been described as inadequate place for end-of-life care, many deaths still occur in hospital settings. Although patient-reported outcome measures have shown positive effects for patients in need of palliative care, little is known about how to implement them. We aimed to explore the feasibility of a pilot version of an implementation strategy for the Integrated P

Factors Influencing Need for Late ASD Closure after Neonatal Repair of Severe Pulmonary Valve Obstruction and Intact Ventricular Septum

Background: In neonates with critical pulmonary stenosis (CPS) or pulmonary atresia with intact ventricular septum (PAIVS), a nonrestrictive atrial septal defect (ASD) has been speculated to improve the initial clinical course after pulmonary valvotomy (PV) but some concerns exist in terms of its potentially longterm adverse effect on the right ventricle`s (RV) growth and persistent desaturation d

The integrated palliative care outcome scale for patients with palliative care needs : Factors related to and experiences of the use in acute care settings

ObjectiveImplementation of patient-reported outcome measures for patients with palliative care needs is characterized by both enablers and barriers. The ways in which healthcare professionals experience the use of assessment tools is important. Our aims were to explore factors contributing to or hindering patients with palliative care needs in assessing their symptoms with the Integrated Palliativ

Quantitative in-cylinder fuel measurements in a heavy duty diesel engine using structured laser illumination planar imaging (SLIPI)

Laser-induced fluorescence (LIF) for quantitative fuel concentration measurements in a combustion engine is a challenging task. Measuring close to the walls of the combustion chamber is even more challenging as both the incident laser light and the signal are strongly reflected on the walls of the combustion chamber. By using a new technique called Structured Laser Illumination Planar Imaging (SLI

Plattformssamhället : Den digitala utvecklingens politik, innovation och reglering

Begreppet plattformar har under de senaste åren seglat upp som ett av de mest centrala begreppen i den digitala ekonomin. Digitala plattformar möjliggör mängder av nya, effektiva sätt att organisera samhället – med långtgående konsekvenser för en rad centrala samhällsfunktioner. Detta ställer en rad frågor om medbestämmande och reglering, om innovationens förutsättningar och hur en plattformsmedve

Bleeding complications after cardiac arrest and targeted temperature management, a post hoc study of the targeted temperature management trial

Target Temperature Management (TTM) is standard care following out of hospital cardiac arrest (OHCA). The aim of the study was to evaluate if treatment temperature (33°C or 36°C) or other predefined variables were associated with the occurrence of bleeding in the TTM study. This study is a predefined, post hoc analysis of the TTM trial, a multinational randomized controlled trial comparing treatme

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Malignant melanoma (MM) is a frequent form of cancer with increasing incidence. 6-10% of patients with MM report a family history of MM, and in most populations 2% of unselected cases of MM carry a CDKN2A mutation. tvWe present a family with 24 cases of MM in nine persons from several generations, caused by a previously undescribed germ-line intronic mutation in CDKN2A. Through genetic counselling

StanceXplore: Visualization for the Interactive Exploration of Stance in Social Media

The use of interactive visualization techniques in Digital Humanities research can be a useful addition when traditional automated machine learning techniques face difficulties, as is often the case with the exploration of large volumes of dynamic—and in many cases, noisy and conflicting—textual data from social media. Recently, the field of stance analysis has been moving from a predominantly bin

Gene expression profiling of first trimester placentas from pregnancies at high risk of developing preeclampsia

INTRODUCTION: Preeclampsia (PE) is an important cause of fetal and maternal morbidity and mortality. It is considered a two-stage disease, the first stage characterized by a defect placentation and the second stage by maternal manifestations. Details of the patho-physiology behind the transition from stage one to stage two remain unclear.OBJECTIVE: Was to study first trimester placental gene expre

Ruling out risks in medical research

In medical research, it is not unusual that risks are ruled out without any specification the exact risk that was ruled out. This makes it difficult to balance expected health benefits and risk of harm when choosing between alternative treatment options. International guidelines for reporting medical research results are sufficiently specific when it comes to establishing health benefits. However,

Efterkrigstidens samhällskontakter

Propaganda, upplysning, pr och information. Detta är några exempel på efterkrigstidens mångfacetterade kommunikationsbegrepp. Under perioden från andra världskrigets slut till 1980-talet var Sverige en framväxande välfärdsstat, och mediernas möjligheter att fostra, påverka och utbilda diskuterades regelbundet. Men i vilka sammanhang användes dessa begrepp och hur omsattes de i praktiken? I Efterkr