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English Medium Instruction in Multilingual and Multicultural Universities analyses the issues related to EMI at both a local and international level and provides a broad perspective on this topic. Drawing on field studies from a Northern European context and based primarily on research carried out at the University of Copenhagen, this book:• introduces a topical global issue that is central to the
Sanfilippo C syndrome (Mucopolysaccharidosis IIIC) is a rare lysosomal storage disorder caused by mutations in the HGSNAT gene. It is characterized by a progressive and severe neurodegeneration, for which there is no treatment available. Here, we report the generation of two HGSNAT-mutated cell lines from a healthy human induced pluripotent stem cell (hiPSC) line using CRISPR/Cas9 editing. These n
Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity, which obstructs the efficient eradication of the tumor. Tumor heterogeneity is often associated with the presence of cancer stem cells (CSCs), a cancer cell sub-population possessing a panel of stem-like properti
Very few countries have managed to decouple economic growth from resource use and greenhouse gas emissions in absolute terms and at rates to meet the climate targets of the Paris Agreement. To achieve this, technological solutions would need to be combined with sufficiency-oriented policies in a postgrowth context. This paper develops policy ideas for a sustainable welfare–work nexus via citizen e
Organic colloids are an important part of dissolved organic matter (DOM) yet many of their properties remain elusive. The main aims of this study were to assess how the colloidal properties of DOM extracted with water from an organic boreal soil horizon varied with the extraction protocol, and thereby provide insight into the nature of the DOM colloids and develop a mechanistic understanding of ho
Maternal drug abuse during pregnancy is a rapidly escalating societal problem. Psychostimulants, including amphetamine, cocaine, and methamphetamine, are amongst the illicit drugs most commonly consumed by pregnant women. Neuropharmacology concepts posit that psychostimulants affect monoamine signaling in the nervous system by their affinities to neurotransmitter reuptake and vesicular transporter
Chronic sun-damaged (CSD) melanoma represents 10%-20% of cutaneous melanomas and is characterized by infrequent BRAF V600E mutations and high mutational load. However, the order of genetic events or the extent of intra-tumor heterogeneity (ITH) in CSDhigh melanoma is still unknown. Ultra-deep targeted sequencing of 40 cancer-associated genes was performed in 72 in situ or invasive CMM, including 2
Owing to the significant societal value of inland water resources, there is a need for cost-effective monitoring of water quality on large scales. We tested the suitability of the recently launched Sentinel-2A to monitor a key water quality parameter, coloured dissolved organic matter (CDOM), in various types of lakes in northern Sweden. Values of a(420)CDOM (CDOM absorption at 420 nm wavelength)
The dry and wet deposition of nitrate, NO3−, and ammonium, NH4+, were estimated for Norway spruce forests at ten monitoring sites across Sweden for the years 2014–2017. The particulate dry deposition was estimated based on measurements using Teflon string samplers as surrogate surfaces, in combination with the net throughfall deposition for sodium (throughfall subtracted with wet deposition). The
Gender identities are relevant for sustainable transport. By analyzing the synergies between gender inequality (as a problem), and lack of sustainability (another problem), there is a potential to create an understanding of how these problems are linked. Our aim is to better understand how gendered norms find expression in transport policy and planning. Taking a starting point in gender studies we
Aims: The aim of the present study was to compare outcomes of endovascular surgery versus open vascular surgery in patients with diabetic foot ulcer (DFU) and peripheral arterial disease (PAD). Methods: Between 1984 and 2006, 1151 patients with DFU were admitted to the diabetic foot care team. Three hundred seventy-six patients with 408 limbs were consecutively included at a multidisciplinary foot
Purpose: Elevated plasma concentration of the vasopressin marker copeptin and low water intake are associated with elevated blood glucose and diabetes risk at a population level. Moreover, in individuals with low urine volume and high urine osmolality (u-Osm), water supplementation reduced fasting plasma (fp) copeptin and fp-glucose. In this observational study, we investigated if low total water
From the global to the local level, gender inequality is the most persistent and entrenched challenge to development. The local level of governance is closest to citizens. Decisions taken at this level have the most direct effect on citizen’s everyday lives, as improvements in living, working and leisure conditions depend on good local governance. This chapter focuses on local government. It attem
Background: Health-related quality of life (HRQoL) has been reported for out-hospital (OHCA) and in-hospital cardiac arrest (IHCA) separately, but potential differences between the two groups are unknown. The aim of this study is therefore to describe and compare HRQoL in patients surviving OHCA and IHCA. Methods: Patients ≥18 years with Cerebral Performance Category 1–3 included in the Swedish Re
The response of evapotranspiration (ET) to warming is of critical importance to the water and carbon cycle of the boreal biome, a mosaic of land cover types dominated by forests and peatlands. The effect of warming-induced vapour pressure deficit (VPD) increases on boreal ET remains poorly understood because peatlands are not specifically represented as plant functional types in Earth system model
Chills and vomiting have traditionally been associated with severe bacterial infections and bacteremia. However, few modern studies have in a prospective way evaluated the association of these signs with bacteremia, which is the aim of this prospective, multicenter study. Patients presenting to the emergency department with at least one affected vital sign (increased respiratory rate, increased he
