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Introduction: Most previous joint imaging scales for haemophilia have focused on earlier disease stages observed in younger patients. Aim: We sought to demonstrate that the 45-item extended magnetic resonance imaging (eMRI) scale is a valid instrument for measuring joint status in adults with severe haemophilia A. Methods: Six scale categories (effusion/haemarthrosis, synovial hypertrophy, hemosid
The single Trp of human cystatin C, Trp-106, is located in the second hairpin loop of the proteinase binding surface. Substitution of this residue by Gly markedly altered the spectroscopic changes accompanying papain binding and reduced the affinity for papain, actinidin, and cathepsins B and H by 300-900-fold. The decrease in affinity indicated that the side chain of Trp-106 contributes a similar
Popular Abstract in Swedish Störd magsäcksfunktion är en vanligt förekommande komplikation bland den snabbt tilltagande populationen av diabetiker i världen, också inkluderande andra patient grupper så som de många patienter med diffusa besvär från magen (funktionell dyspepsi). Fördröjd magsäckstömning (gastropares) kan dels leda till en rad obehagliga symtom förknippade med födointaget (tidig mätAbnormal gastric motor function, a frequent complication among the increasing diabetic population of the world, also includes other patient groups such as those many patients with functional dyspepsia. These facts stress the need for a reliable, safe, cost-effective, and simple technique for measuring gastric emptying. To date the ultrasound technique for measuring gastric emptying has been regard
Under 1680-talet trädde Sophia Elisabet Brenner fram som poet och blev snart känd och uppskattad för sina dikter vid olika tillfällen i livet. Tillfällesdiktningen var en flexibel genre som gav henne möjligheten att resonera om tidens aktuella frågor, till exempel kvinnans ställning i äktenskap och samhälle eller värderingen av det som var gammalt och fornt och det som var nytt. Hennes rykte spred
Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET sca
Clin Microbiol InfectAbstract The usefulness of spa typing was evaluated in relation to pulsed-field gel electrophoresis (PFGE), as a tool for epidemiological typing of methicillin-resistant Staphylococcus aureus (MRSA) in a low-prevalence region in southern Sweden. Bacterial isolates from 216 MRSA cases, newly identified in 2000-2004, were studied. The isolates were obtained from infected patient
GABA is the major inhibitory neurotransmitter in the CNS and changes in GABAergic neurotransmission affect the overall activity of neuronal networks. The uptake of GABA into synaptic vesicles is mediated by the vesicular GABA transporter (VGAT), and changes in the expression of the transporter directly regulate neurotransmitter release. In this work we investigated the changes in VGAT protein leve
Two searches for supersymmetric particles in final states containing a same-flavour opposite-sign lepton pair, jets and large missing transverse momentum are presented. The proton-proton collision data used in these searches were collected at a centre-of-mass energy root s = 8TeV by the ATLAS detector at the Large Hadron Collider and corresponds to an integrated luminosity of 20.3 fb(-1). Two lept
Total levels of circulating prostate-specific antigen (tPSA) are strongly associated with prostate cancer (PCa) risk and outcome but benign prostate disease is the most frequent cause of a moderately elevated PSA level. Free PSA (fPSA) forms are independently associated with PCa risk and contribute modest diagnostic enhancements above and beyond tPSA alone. We developed an immunoassay for fPSA sub
This paper reports on a search for narrow resonances in diboson production in the [Formula: see text] final state using [Formula: see text] collision data corresponding to an integrated luminosity of [Formula: see text] fb[Formula: see text] collected at [Formula: see text] TeV with the ATLAS detector at the Large Hadron Collider. No significant excess of data events over the Standard Model expect
A search for a dark photon, a new light neutral particle, which decays promptly into collimated pairs of electrons or muons is presented. The search targets dark photons resulting from the exotic decay of the Standard Model Higgs boson, assuming its production via the dominant gluon-gluon fusion mode. The analysis is based on 140fb-1 of data collected with the ATLAS detector at the Large Hadron Co
Purpose: Positron emission tomography (PET) is increasingly used in neuro-oncology. However, little is known about its application across European institutions and reasons for variable implementation. Methods: Between June and August 2024, members of the European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) completed a cross-sectional online survey on PET use
Introduction: Understanding symptom patterns in atrial fibrillation (AF) can help in disease management. We report on the application of natural language processing (NLP) to electronic medical records (EMRs) to capture symptom reports in patients with newly diagnosed (incident) AF. Methods and Results: This observational retrospective study included adult patients with an index diagnosis of incide
A search for diphoton resonances in the mass range between 10 and 70 GeV with the ATLAS experiment at the Large Hadron Collider (LHC) is presented. The analysis is based on pp collision data corresponding to an integrated luminosity of 138 fb −1 at a centre-of-mass energy of 13 TeV recorded from 2015 to 2018. Previous searches for diphoton resonances at the LHC have explored masses down to 65 GeV,
Mexico City’s water system is not sustainable. There is an unfair inequality gap in the quantity and quality of water access for its residents. Moreover, the groundwater aquifers in the city are being over-exploited and polluted. This has resulted in the sinking of the city, damage to the ecosystems, and the reduction of water access to Mexico City’s residents. As the policies are a direct instrum
Soil as a fundamental, conditionally renewable natural resource is increasingly under threat from unsustainable farming practices in a changing environment. In Hungary, expansive areas of land are susceptible to soil degradation, while only a small percentage of farmers currently applies soil conservation practices (SCPs). Degraded soils have an impact on food production, climate adaptation, clima
A search is presented for direct pair production of the stop, the supersymmetric partner of the top quark, in a decay through an Formula Presented-parity violating coupling to a charged lepton and a Formula Presented-quark. The dataset corresponds to an integrated luminosity of Formula Presented of proton-proton collisions at a center-of-mass energy of Formula Presented collected between 2015 and
The outbreak of the Covid-19 pandemic triggered changed circumstances extensively. One aspect of such changes arise from issues in cross-border supply contracts, for example due to incapability of contractual performance because of entry bans and lack of labor force as the employees were set on quarantines. Usually contractual non-performance leads to breacher’s liability for damages, but exceptio
In this thesis an optimization of a previously performed inclusive search for beyond Standard Model Physics in same-sign di-lepton final states is performed, but tuned for a doubly-charged Higgs boson decaying to same-sign di-muons. The doubly-charged Higgs boson is a proposed fundamental particle whose existence would provide evidence for theoretical extensions of the Standard Model (SM) of parti
