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We have evaluated the efficiency of two popular end-point methods to calculate ligand-binding free energies, LIE (linear interaction energy) and MM/GBSA (molecular mechanics with generalized Born surface-area solvation), i.e. the computational effort needed to obtain estimates of a similar precision. As a test case, we use the binding of seven biotin analogues to avidin. The energy terms used by M
A search for Higgs boson production in association with a W or Z boson, in the H -> WW* decay channel, is performed with a data sample collected with the ATLAS detector at the LHC in proton-proton collisions at centre-of-mass energies root s = 7 TeV and 8TeV, corresponding to integrated luminosities of 4.5 fb(-1) and 20.3 fb(-1), respectively. The W H production mode is studied in two-lepton and t
Background Trauma and its complications contribute to morbidity and mortality in the general population. Trauma victims are susceptible to acute respiratory distress syndrome (ARDS) and sepsis. Polymorphonuclear leucocytes (PMNs) are activated after trauma and there is substantial evidence of their involvement in the development of ARDS. Activated PMNs release heparin-binding protein (HBP), a gran
The Swedish national register of severe alpha1-antitrypsin (AAT) deficiency was established in 1991. The main aims are to prospectively study the natural history of severe AAT deficiency, and to improve the knowledge of AAT deficiency. The inclusion criteria in the register are age ≥18 years, and the PiZ phenotype diagnosed by isoelectric focusing. The register is kept updated by means of repeated
Background. The objective was to determine how postmenopausal bleeding (PMB) is managed in Sweden today, and to relate the findings to a new evidence-based algorithm for the management of PMB. Methods. A questionnaire regarding the role of ultrasound and the use of different endometrial biopsy methods in the management of PMB was sent to all 61 gynecologic departments in Sweden. Results. Fifty-n
This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim,
Heterologous genes for xylose utilization were introduced into an industrial Saccharomyces cerevisiae, strain A, with the aim of producing fuel ethanol from lignocellulosic feedstocks. Two transformants, A4 and A6, were evaluated by comparing the performance in 4-l anaerobic batch cultivations to both the parent strain and a laboratory xylose-utilizing strain: S. cerevisiae TMB 3001. During growth
Pre-treatment of sisal pulp prior to its anaerobic digestion was investigated using an activated sludge mixed culture under aerobic conditions in batch bioreactors at 37 degrees C. The progression of aerobic pre-treatment of the residue in relation to the activities of some extracellular hydrolytic enzymes in the slurry was monitored. The highest activity of hydrolytic enzymes was obtained at 9 h
We have examined concurrent and prospective validity of an index of self-reported walking (RW) of 307 home-dwelling women aged 75 years and above, of whom 155 in 1 year had in all 308 falls of which 13% resulting in fractures. It consists of five items concerning various aspects of self-reported walking identified by factor analysis. The sum score on this ''RW-index'' correlated moderately ( r = 0
Popular Abstract in Swedish Malmö erbjuder speciellt goda möjligheter till epidemiologiska studier, därför att all sjukhusbunden vård erbjuds av ett enda sjukhus som dessutom i stort sett endast täcker Malmös egna behov. Därtill kommer att nu avlidne professor Folke Linell redan under 1950-talet insåg den stora betydelsen för sjukvårdens kvalitet av en omfattande obduktionsverksamhet. Under periodIn the present thesis incidence, survival, mortality, cure and prognosis in invasive breast cancer in Malmö was studied over a 30 year period. Validated data from the Cancer Registry and the Cause of Death Registry were used. In the process of validation systematical biases were identified in both registers. The incidence increased over time and was strongly related to increases in diagnostic acti
Background: The slopes of the eastern Andes harbour some of the highest biodiversity on Earth and a high proportion of endemic species. However, there have been only a few and limited descriptions of carbon budgets in tropical montane forest regions. Aims: We present the first comprehensive data on the production, allocation and cycling of carbon for two high elevation (ca. 3000 m) tropical montan
In a warming climate, mercury (Hg) pathways in the Arctic can be expected to be affected. The Hg transport from the high arctic Zackenberg River Basin was assessed in 2009 in order to describe and estimate the mercury transported from land to the marine environment. A total of 95 water samples were acquired and filtered (0.4 mu m pore size), and Hg concentrations were determined in both the filter
Male patients with terminal renal failure are often infertile and exhibit an abnormal sex hormone pattern in plasma. We studied patients in all chronic kidney disease (CKD) stages to determine plasma levels of anti-Müllerian hormone (AMH), a Sertoli cell-derived marker, and other sex hormones. Seventy-eight male patients with CKD stages 1-5 and a median age of 40 years (22-50 years), as well as 20
PURPOSE: To evaluate the results of primary stenting in aortic occlusive disease. METHODS: Thirty patients underwent primary stenting of focal concentric (n = 2) and complex aortic stenoses (n = 19), and aortic or aorto-iliac occlusions (n = 9). Sixteen patients underwent endovascular outflow procedures, three of whom also had distal open surgical reconstructions. Median follow-up was 16 months (r
Objective - People living in eastern Finland have approximate to 40% higher coronary heart disease mortality rates than western Finns. Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns. Methods and Results - As part of a longitudinal follow-up study, we measured carotid intima-
