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Objective. Uterine sarcomas (US) are rare malignancies with unclear aetiology. Studies on uterine sarcomas in the setting of second primary malignant tumours can provide clues to aetiology and identify side effects of different treatments. Methods. A cohort of 8606 cases of US was extracted from the data from 13 cancer registries and followed for second primary cancers within the period 1943-2000.
Background/Objectives:Diets high in saturated and trans fat and low in unsaturated fat may increase type 2 diabetes (T2D) risk, but studies on foods high in fat per unit weight are sparse. We assessed whether the intake of vegetable oil, butter, margarine, nuts and seeds and cakes and cookies is related to incident T2D.Subjects/Methods:A case-cohort study was conducted, nested within eight countri
Background: 21-Hydroxylase autoantibodies (21OHAb) are markers of an adrenal autoimmune process that identifies individuals with autoimmune Addison's disease (AAD). Quality and inter-laboratory agreement of various 21OHAb tests are incompletely known. The objective of the study was to determine inter-laboratory concordance for 21OHAb determinations. Methods: Sixty-nine sera from 51 patients with A
Objective: GH and IGFs have mitogenic properties, causing speculation that GH treatment could increase risk of malignancy. While studies in GH-treated childhood cancer survivors have suggested a slight increase in second neoplasms, studies in GH-treated adults have been equivocal. Design: Incidence of de novo and second cancers was evaluated in 6840 GH-treated and 940 non GH-treated adult patients
Background: More knowledge is needed on potential associations between individual-, family-, and neighborhood-level factors and psychiatric disorders in children and adolescents. Aims: To examine associations between, individual-, family-, and neighborhood-level factors and incident internalizing (anxiety and mood) disorders and externalizing (ADHD and conduct) disorders in children and adolesc
Background: The role of inflammatory and hemodynamic stress biomarkers in heart failure (HF) patients treated de novo with beta-blockers has been poorly studied. Methods: A total of 86 patients (age 56 +/- 9 years, 81 men) with left ventricular ejection fraction (LVEF) < 40% and previously not treated with beta-blockers were initiated on carvedilol. At baseline and 12 months later we performed ech
Purpose: Here, we describe an integrated bioinformatics, functional analysis, and translational pathology approach to identify novel miRNAs involved in breast cancer progression. Experimental Design: Coinertia analysis (CIA) was used to combine a database of predicted miRNA target sites and gene expression data. Using two independent breast cancer cohorts, CIA was combined with correspondence anal
A palaeomagnetic, geochronologic and geochemical study of basic dykes in the Ukrainian Shield has been undertaken with the purpose of testing a hypothesis for timing of accretion of the Ukrainian Shield with Fennoscandia. On the basis of geological data it has been suggested that the two shields amalgamated at ca. 1900-1800 Ma. With this study of 11 basic dykes the palaeomagnetic database for the
Background: Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In an expression study of intraorbital tissue, adipocyte-related immediate early genes (IEGs) and immunomodulatory genes were found to be overexpressed in patients with Graves' ophthalmopathy (GO). We hypothesized that genetic variations in these genes could be associated with GD and/
Föreliggande uppsats syftar till att, ur ett svensk perspektiv, belysa vad pantsättning av varumärken egentligen innebär. Möjligheterna till pantsättning av varumärken, och vad det innebär för en kreditgivare att ha pant i ett varumärke eller varumärkesansökan kommer att utredas. Inledningsvis behandlas den allmänna funktionen och syftet bakom panträtten. Härvid visas att panträttens viktigaste fu
Every third child in Germany has a migration background, which makes social negotiations on the participation of migrants and their descendants in this diverse society increasingly relevant. Therefore, the study examines how Migrant Organisations (MOs) and Post-Migrant Organisations (PMO) engage in contentious politics in the context of this increasing plurality. To do that, the already establishe
Achieving a sustainable Swedish industry will require better utilization of resources already available and already spent. Nationally, vast amounts of heat are released into the atmosphere and not made use of. If only a fraction of this energy could be exploited, the path to net zero emission society by 2045 would be thousands of tons worth of CO2 closer. In Sweden, 25% of excess heat delivered to
Municipal economic policy has a significant role for the municipality in a time of globalisation to boost growth and thereby welfare. The study aims to understand the ideas reflected in a municipality's economic policy and how they take their expression. The study aims to construct a model to understand these ideas and expressions, an analytic tool which will help to analyze a municipality'
This thesis aims to investigate if Moody’s is more accurate than logistic regression and the Merton model in predicting default by firms issuing corporate debt after the financial crisis. This is achieved by comparing the Expected Default Probabilities (EDPs) in Moody’s migration table published in their annual default study reports against the calculated EDPs from logistic regression and the Mert
Bolagsordningar och aktieägaravtal skapar en hel del rättsfrågor, både individuellt och ihop. Många problem rör rättshandlingarnas rättsverkningar och vad verkningarna innebär för aktieägarna, bolaget och övriga avtalsparter. Dessa rättsfrågor har utretts i denna text och särskild hänsyn tagits till hur skydd för svagare part formar och påverkar rättsverkningarna för bolagsordningen och aktieägaraArticles of association and shareholders’ agreements create many legal issues both individually and together. Many of the problems revolve around the legal effects of the acts; what the effects entail for the shareholders, the company and other contractors. These questions have been examined in this text and special regards have been given to how protection for weaker parts form and affect the leg
