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Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un

BackgroundVentral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of Parkinson’s Disease (PD). However, one main challenge in the quality control of the cells is that rostral and caudal VM progenitors are extremely similar tr

In this commentary, we reflect on the program chair experience of ICIS 2015 to pass on some useful organizational memory for the IS community at large. We also reflect on volunteer effort required for a high-quality conference and the challenges of maintaining quality over a diverse and dispersed reviewing effort. We ask whether we can count on this volunteer effort in a changing higher education

The use of protective gloves is of importance in workplaces where hazardous chemicals are handled, including the chemical industry, the plastic industry, as well as in environments such as dental practices, hairdressing, and beauty salons. Occupational dermatology can provide crucial advice regarding how to avoid or protect the patient against allergens found in the work environment and provide th

Label-free chemical imaging of living and functioning systems is the holy grail of biochemical research. However, existing techniques often require extensive sample preparation to remove interfering molecules such as water, rendering many molecular imaging techniques unsuitable for in situ structural studies. Here, we examined freshly extracted tissue biopsies and living small vertebrates at submi

The implementation of circular initiatives requires certain capabilities and knowledge that traditional business models often lack, requiring new perspectives and external collaborations. While it is understood that partnerships can aid in innovation and provide knowledge and capabilities to firms, the dynamics of collaboration for the transition towards circular business models (CBMs) need to be

Have Orthodox Christian churches engaged in creation of novelreligious practices during the coronavirus pandemic? How dothose practices emerge, and how do laypeople respond to them?This article addresses these questions by reflecting on the majorproject findings based on examination of Orthodox churches ofRussia, Ukraine and Georgia. The findings build on a theoreticalframework that includes sever

Abstract in UndeterminedThe aim of this study was to investigate how well subjects beat out a rhythm using eye movements and to establish the most accurate method of doing this. Eighteen subjects participated in an experiment were five different methods were evaluated and a fixation based method was found to be the most accurate. All subjects were able to synchronize their eye movements with a giv

Forestry has been one of the major industries in the Swedish economy since the middle of the nineteenth century. During the second part of the twentieth century the industry went through powerful technological changes. Traditional handicraft methods were replaced by modern high technology. As for the forestry VET this meant a strong expansion during the 1950s and 1960s followed by integration into

Any diplomatic resolution of Iran’s nuclear controversy will deprive Israeli hawks of what they see as the sole feasible justification to overthrow the Iranian regime by military force.