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Purpose: Gender dysphoria is commonly conceptualized as a mental disorder in gender-diverse people who do not identify with the gender assigned to them at birth. Direct support for well-being tends to be delegated to the field of mental health (MH), whereas speech-language pathology (SLP) practice is charged with modifying gender-diverse people's voice and communication in the belief that well-bei
The stability of relaxation techniques has been studied for strongly coupled fluid-structure interaction (FSI) with application to a cantilever immersed in channel flow. The fluid is governed by Navier–Stokes equations for incompressible flow condition using turbulence modeling, and the solid is governed by the equation of motion with compressible material modeling. The applied kinematic descripti
Research on the efficacy of hypnosis applications continues to grow, but there remain major gaps between the science and clinical practice. One challenge has been a lack of consensus on which applications of hypnosis are efficacious based on research evidence. In 2018, 6 major hypnosis organizations collaborated to form the Task Force for Establishing Efficacy Standards for Clinical Hypnosis. This
Urban flood damage leads to major costs for private house owners, insurance companies, and water and wastewater utilities. Analysis of flood damage claims can be used to improve the understanding of the details of flood damage characteristics and reasons for drainage system failures. However, few studies have used data of this kind to investigate urban flood characteristics. We examined 3113 damag
Joint time-frequency representations are important tools when estimating the instantaneous frequency. The widely used spectrogram is known to have poor energy localisation, which the reassignment method improves. However, the reassignment method is sensitive to noise. In this paper we present a multitaper reassigned spectrogram (MTRS) that is robust to noise and tailored to short duration transien
Transportation infrastructure that accommodates the needs of active mode users is an essential element of sustainable and just urban mobility transitions. Safety is a major factor influencing bicyclist behavior, and understanding how safety is perceived by traffic participants can support urban designs that will attract greater shares of active travelers. This paper evaluates the stated preference
The paper suggests a method for compensating the impact of friction for the control nonlinear systems, where the original controller (derived without taking into account friction) results from the passivity relation. The illustrative example is given.
The throughput of macromolecular X-ray crystallography experiments has surged over the last decade. This remarkable gain in efficiency has been facilitated by increases in the availability of high-intensity X-ray beams, (ultra)fast detectors and high degrees of automation. These developments have in turn spurred the development of several dedicated centers for crystal-based fragment screening whic
This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are aut
No-go decay (NGD) targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. The crystal structure of a Schizosaccharomyces pombe Dom34-Hbs1 complex reveals an overall shape similar to that of eRF1-eRF3-GTP and EF-Tu-tRNA-GDPNP. Similarly to eRF1 and GTP binding to eRF3, Dom34 and GTP bind to Hbs1 with strong cooperativity,
Emerging data indicates SGRT could improve safety and quality by preventing errors in its capacity as an independent system in the treatment room. The aim of this work is to investigate the utility of SGRT in the context of safety and quality. Three incident learning systems (ILS) were reviewed to categorize and quantify errors that could have been prevented with SGRT: SAFRON (International Atomic
We investigate how users on a prominent forum for white supremacists interpreted and framed two seminal events for the far-right in the U.S., the elections of Obama in 2008 and Trump in 2016. These cases precipitated dramatic shifts in the far-right alliance and conflict structure. We combine computational methods and qualitative analysis on a corpus of over ten million posts on Stormfront.org to
Bacterial endotoxin is a potent inflammatory antigen abundant in the human intestine. Endotoxins circulate in the blood at low concentrations in all healthy individuals. Elevated levels of circulatory endotoxins may cause inflammation with the development of chronic disease, either affecting metabolism, neurological disease, or resistance to viral and bacterial infections. The most important endot
BACKGROUND: Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after liver resection/ablation for SCC liver metastases and factors associated with recurrence-free survival (RFS) and overall survival (OS). METHOD: Members of the Eur
In order to reduce maritime transportation's greenhouse gas and pollutant emissions, marine engine manufacturers need to deepen the fundamental understanding of the injection and spray process. Two-dimensional unsteady-state Reynolds-averaged Navier-Stokes simulations were conducted to investigate evaporating high-pressure marine engine sprays, in which an injector with a nozzle diameter of 0.44 m
We approach critically the assertion that a referendum ultimately defends the “traditional family,” by examining the articulation of anti-gender politics in Romanian parliamentary debates. We contribute theoretically by employing the concept of retrogressive mobilization in plebiscitary circumstances. We show that in Romania the contours of retrogressive mobilization transgress both the ideologica
As organizations continue to adapt and evolve to meet the challenges related to globalization and working with new collaboration technologies to bridge time and space, demands on employees’ time and attention continue to increase. Recognizing this problem and its implications, such as increased employee turnover, many companies are seeking ways to help their employees maintain a healthy balance be
The various types of phase-change materials (PCMs), which absorb or release stored latent heat when they change phases causing cooling and warming effects, are described and the working principles are outlined. The various ways of incorporating PCMs into textiles for protective clothing are explored, and critical factors identified that determine the effectiveness of PCM cooling and warming effect
