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A century of trends in adult human height

Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2

The Montreal Cognitive Assessment : Normative Data from a Large Swedish Population-Based Cohort

Background: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and not been thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. Objective: To establish norms for MoCA a

Spela för att läsa! En studie om GraphoLearns effekter på avkodningsförmåga hos barn i åldrarna 6 till 7 år

Syfte: Huvudsyftet med studien var att undersöka den phonicsbaserade lärappen GraphoLearns effekter på avkodningsförmågan hos svensktalande barn i tidig läsutveckling. Sekundärt var syftet att undersöka huruvida träning med GraphoLearn kan påverka hjärnstruktur. Studien kan betraktas som en pilotstudie för ett större pågående projekt. Metod: Fjorton deltagare i åldrarna 6 till 7 år inkluderades. S

”Hjärtat slår och det känns som dom håller på att dö eller svimma” : en kvalitativ studie av hur lärare kan arbeta med talrädsla vid muntliga framställningar i svenskämnet i gymnasieskolan

I denna uppsats står rädsla för att tala i fokus. Talrädsla belyses med retorikämnet som grund, och studien tar avstamp i den svenska gymnasieskolan. Syftet med studien är att ta fram ett handfast material för hur svensklärare på gymnasieskolan kan arbeta med talrädda elever. För att uppnå syftet genomförs en litteraturstudie, där handböcker som behandlar området talrädsla studeras. I dessa handböIn this study, language anxiety is in focus. Language anxiety is studied with the subject of rhetoric as a basis, and the study is based on the Swedish upper secondary school. The aim of the study is to produce a solid material for how Swedish teachers at upper secondary school can work with students with language anxiety. In order to achieve this purpose, a literature study is carried out, in whi

Borta bra, hemma värst - En undersökning av det föreslagna barnfridsbrottet utifrån principer för kriminalisering

Våld i nära relationer och särskilt mäns våld mot kvinnor, anses idag utgöra ett allvarligt samhällsproblem. Det finns studier som visar att ungefär vart tionde barn i Sverige någon gång har upplevt våld mellan närstående vuxna. Detta kan få förödande konsekvenser för barnet i form av både fysiska och psykiska skador. Att låta barn bevittna våld eller andra brottsliga gärningar mellan närstående äViolence in close relationships and especially men’s violence against women, is today considered a social problem. There are studies showing that approximately every tenth child in Sweden has ever experienced violence between related adults. This can cause devastating consequences for a child, such as both physical and mental injuries. Letting children witness violence or other criminal acts betwe

All makt åt Tegnell - Vår befriare och förgörare

Sammanfattning Examensarbetes titel “All makt åt Tegnell - vår befriare och förgörare” - en kvalitativ dokumentstudie om följares konstruktioner av Anders Tegnell på Twitter Handledare Nadja Sörgärde Fem nyckelord Följare som konstruktörer av ledarskap, Anders Tegnell, Twitter, Kris och Attribution Forskningsfråga Hur framställs Anders Tegnell på Twitter? Syfte Syftet med denna studie är att

”Kvinnor anses inte lämpade inom domarämbetet” - En rättshistorisk studie av motiven till behörighetslagen 1923 med fokus på domaryrket

Denna uppsats handlar om den delen av kvinnorörelsens historia där kvinnors rätt till högre statstjänster berörs. I takt med industrialiseringen förändrades det svenska samhället och medförde att kvinnor tog plats på arbetsmarknaden på ett helt annat sätt än tidigare. Sedan mitten av 1800-talet var kvinnor aktiva på den statliga arbetsmarknaden och fick tillträde till universitetsstudier i början This essay is about the part of the history of the women's movement where women's right to higher civil service is affected. In time as the industrialization happened, Swedish society changed which resulted in that women took their place in the labor market in a completely different way than before. Since the middle of the 19th century, women were active in the state labor market and gaine

Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis.

We explore cell heterogeneity during spontaneous and transcription-factor-driven commitment for network inference in hematopoiesis. Since individual genes display discrete OFF states or a distribution of ON levels, we compute and combine pairwise gene associations from binary and continuous components of gene expression in single cells. Ddit3 emerges as a regulatory node with positive linkage to e

Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer.

Breast cancer (BC) is one of the leading causes of death among women worldwide. Immunostimulatory treatment has increasingly been used as adjuvant therapy in the last few years, in patients with melanoma and other cancer forms, often with an induction of autoimmunity as a consequence of a successful treatment. We aimed at investigating if coexisting autoimmune diseases (AD) or hypersensitivities (

Effect of Complement on HIV-2 Plasma Antiviral Activity Is Intratype Specific and Potent

Human immunodeficiency virus type-2 (HIV-2) infected individuals develop immunodeficiency with a considerable delay and transmit the virus at a lower rate as compared to HIV-1 infected. Conceivably, comparative studies on immune responsiveness of the HIV-1 and HIV-2 infected hosts may help to explain differences in pathogenesis and transmission between the two types of infection. Previous studies

MafA and MafB Regulate Genes Critical to beta-Cells in a Unique Temporal Manner

OBJECTIVE-Several transcription factors are essential to pancreatic islet beta-cell development, proliferation, and activity, including MafA and MafB. However, MafA and MafB are distinct from others in regard to temporal and islet cell expression pattern, with beta-cells affected by MafB only during development and exclusively by MafA in the adult. Our aim was to define the functional relationship

Breast cancer and spider telangiectasias at diagnosis and its relation to histopathology and prognosis: a population-based study.

Angiogenesis is one of the hallmarks of breast cancer. The status of angiogenesis is important in therapy choice. Spider telangiectasias (telangiectasias) may reflect an increased ability to form vessels. Our first aim was to identify patient and tumor characteristics associated with the occurrence of telangiectasias at the time of breast cancer diagnosis. The second aim was to study the overall s

Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women : a cohort study

BACKGROUND: Obesity is a well established risk factor of colorectal cancer (CRC), but how body size influences risk of colorectal cancer defined by key molecular alterations remains unclear. In this study, we investigated the relationship between height, weight, body mass index (BMI), waist- and hip circumference, waist-hip ratio (WHR) and risk of CRC according to expression of beta-catenin, cycli

Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-analysis

OBJECTIVE-Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for beta-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants. RESEARCH DESIGN AND METHODS-We conducted a 14-cohort meta-

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar

Incidence of and risk factors for neonatal morbidity after active perinatal care: extremely preterm infants study in Sweden (EXPRESS)

Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants becaus

Multidisciplinary team conferences promote treatment according to guidelines in rectal cancer

Background. Multidisciplinary team (MDT) conferences have been introduced into standard cancer care, though evidence that it benefits the patient is weak. We used the national Swedish Rectal Cancer Register to evaluate predictors for case discussion at a MDT conference and its impact on treatment. Material and methods. Of the 6760 patients diagnosed with rectal cancer in Sweden between 2007 and 20