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A new animal product free defined medium for 2D and 3D culturing of normal and cancer cells to study cell proliferation and migration as well as dose response to chemical treatment

Cell culturing methods are increasingly used to reduce and replace the use of live animals in biomedical research and chemical toxicity testing. Although live animals are avoided when using cell culturing methods, they often contain animal-derived components of which one of the most commonly used is foetal bovine serum (FBS). FBS is added to cell culture media among other supplements to support ce

Effects of Interface Oxidation on Noise Properties and Performance in III–V Vertical Nanowire Memristors

Memristors implemented as resistive random-access memories (RRAMs) owing to their low power consumption, scalability, and speed are promising candidates for in-memory computing and neuromorphic applications. Moreover, a vertical 3D implementation of RRAMs enables high-density crossbar arrays at a minimal footprint. Co-integrated III–V vertical gate-all-around MOSFET selectors in a one-transistor-o

Redox dynamics of 2D crystalline vanadium oxide phases on high-index anatase facets

Vanadium oxides exist in a multitude of phases with varying structure and stoichiometry. This abundance of phases can be extended through the use of other oxides as supports, and through redox treatments. However, the combined effects of different supports and redox treatments can be difficult to identify, particularly when present as different terminating facets on nanoparticles. Here, we examine

Standardization of serum creatinine is essential for accurate use of unbiased estimated GFR equations : Evidence from three cohorts matched on renal function

Background: Differences in the performance of estimated glomerular filtration rate (eGFR) equations have been attributed to the mathematical form of the equations and to differences between patient demographics and measurement methods. We evaluated differences in serum creatinine (SCr) and eGFR in cohorts matched for age, sex, body mass index (BMI) and measured GFR (mGFR). Methods: White North Ame

Design and development of solid-state nanostructures for catalysis

Catalytic processes are present in a wide range of aspects, from fundamental biological processes to modern chemical synthesis. In practical terms, catalysis has thrived as a rapidly growing industry. However, a significant gap in our understanding of catalytic processes exists between the molecular and industrial scales, arising from the complexity at the nano- and micro-levels of catalytic nanop

Overuse of EEG and ECG in children with breath-holding spells and its implication for the management of the spells

AIM: Breath-holding spells (BHS) are common in children, but evidence-based clinical guidelines are lacking. We investigated a large population-based cohort of BHS patients, to propose a refined description of typical BHS and guidelines for its management.METHODS: In a cross-sectional retrospective study, patients diagnosed with BHS in Southern Sweden 2004-2018 were recruited. Disease characterist

Lead, cadmium, and mercury blood levels in schoolchildren in southern Sweden : Time trends over the last decades

To prevent diseases arising from exposure to toxic metals, more knowledge about their temporal changes is needed, especially in children, the most vulnerable group. This study follows temporal changes in blood lead (BPb), mercury (BHg) and cadmium (BCd) levels in schoolchildren (8–11 years old) from two cities in southern Sweden. One blood sample per 773 children was used for time trend analyses b

Aerosol Synthesis and Characterization of Heterogeneous Bimetallic Nanoparticles

As the proverbial noose tightens around humanity’s resource spending, research is focused on utilizing materials to their fullest potential. Nanotechnology is the ultimate way to economize by splitting objects into smaller parts and dispersing the material properties over greater surface to volume ratios. Emerging quantum effects at the nanoscale present unique tweaking opportunities in applicatio

Combustion of micron-sized Al-Mg alloy wires in hot H2O/O2/N2 flows

The use of aluminum-magnesium (Al-Mg) alloy particle as energetic additive in solid propellants was previously shown to have many advantages over pure Al particle, such as relatively low ignition temperature, high reaction rate and low particle agglomeration rate. In this paper, the combustion of Al-Mg alloy in hot H2O/O2/N2 flows was experimentally studied using wires with a diameter of 200 µm. T

High-k/InGaAs interface defects at cryogenic temperature

Oxide defects in the high-k/InGaAs MOS system are investigated. The behaviour of these traps is explored from room temperature down to 10 K. This study reveals that the exchange of free carriers between oxide states and either the conduction or the valence band is strongly temperature dependant. The capture and emission of electrons is strongly suppressed at 10 K as demonstrated by the collapse of

FGF/FGFR1 system in paired breast tumor-adjacent and tumor tissues, associations with mammographic breast density and tumor characteristics

INTRODUCTION: Mammographic breast density (MBD) is an established breast cancer risk factor, yet the underlying molecular mechanisms remain to be deciphered. Fibroblast growth factor receptor 1 (FGFR1) amplification is associated with breast cancer development and aberrant FGF signaling found in the biological processes related to both high mammographic density and breast cancer microenvironment.

Dynamics of Polarization Switching in Mixed Phase Ferroelectric-Antiferroelectric HZO Thin Films

The polarization switching dynamics for Hf 1-x Zr x O 2 (HZO) integrated on InAs is studied as a function of pulse width and amplitude. Due to a mixed ferroelectric/antiferroelectric phase at x=0.8, a more gradual total polarization update is shown compared to a fully ferroelectric Hf 0.5 Zr 0.5 O 2 stack. A lowered operating voltage is achieved in Hf 0.2 Zr 0.8 O 2 by activating an inner ferroele

Probing the Multiexcitonic Dynamics in CsPbI3 Nanocrystals across the Temperature-Induced Reversible Phase Transitions

CsPbI3 nanocrystals (CPI NCs) have become a trending research topic due to their impressive potential in functional optoelectronic devices and optical gain applications. Their optical responses are governed by carrier dynamics, which is greatly influenced by temperature and corresponding phase structure due to the effects of inherently electron-phonon coupling. Notably, CPI NCs have been identifie

In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations

Here we describe an in vitro co-culture system that can differentiate hematopoietic progenitor populations to all major hematopoietic lineages at clonal level. We present both a sensitive single-cell switch-culture system as well as a less laborious alternative barcoding protocol more convenient for larger cell numbers. Importantly, generation of all lineages from single long-term hematopoietic st

Occurrence of comorbidity following osteoarthritis diagnosis : a cohort study in the Netherlands

Objective: To determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA). Design: A cohort study was conducted using the Integrated Primary Care Information database, containing electronic health records of 2.5 million patients from the Netherlands. Adults at risk for OA were included. Diagnosis of knee or hip OA (=exposure) and 58 long-term comorbidities (=outcome) w