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This paper presents a model for reversed-phase purification of insulin from desamido insulin. The system is described by a reaction dispersive model with a competitive Langmuir isotherm. A model building and calibration method is presented and the model's region of validity is defined. The model is calibrated using only two-component experiments on the raw mixture by the inverse method and then ex
The development of biotechnological products is becoming more and more expensive. One type of protein attracting a great deal of attention in the biopharmaceutical industry is antibodies, which was used in this work. The cost of producing antibodies is, however, high, mainly due to the downstream processing, which constitutes 50–80% of the total cost. This work describes model-based methods to des
The European Pre-Standard for protective clothing against cold ENV 342:1998 suggests that the testing of thermal insulation should be made on a moving thermal manikin. In this way the value can be used to match requirements specified by the IREQ-method or as realistic input for prediction of thermal stress in other standards. It is known from prior work that insulation values measured with human s
Extractability of red pigment from red beetroot was investigated using pulsed electric field (PEF) treated tissue in a solid-liquid extraction process. Thin disks of the tissue were subjected to PEF at different intensities and, 3-4 min after the treatment, the release of red pigment and ionic species into an isotonic solution was measured in situ using a spectrophotometer and a conductivity meter
Pretreatment of mixed softwoods with SO2 impregnation and steam for production of ethanol has been investigated. The optimal conditions, both for sugar yield and ethanol yield, to assess the effect of inhibitors formed in the pretreatment, have been determined. The parameters investigated were: SO2 concentration (1-6% (w/w) dry matter), temperature (190-230 degrees C) and residence time (2-15 min)
A sparse mesh-neighbour based approximate inverse preconditioner is proposed for a type of dense matrices whose entries come from the evaluation of a slowly decaying free space Green's function at randomly placed points in a unit cell. By approximating distant potential fields originating at closely spaced sources in a certain way, the preconditioner is given properties similar to, or better than,
Many economic models contain the single variable 'money'. Money does not exist in the form of a single physical unit and it is common to construct monetary aggregates using the method of simple summations. Monetary aggregation theory lends little or no support to the method of simply summing various monetary asset components up to arbitrary levels of aggregation. In monetary aggregation theory, mo
Forestry in Sweden suffers from browsing damage caused by large herbivores, mainly moose (Alces alces) and roe deer (Capreolus capreolus). Silviculture affects the availability of forage for these animals, and thus the browsing pressure. A step towards modeling the response of trees or to predict browsing damage is to gain more knowledge on the availability of food in forest stands. Individual gap
Objective: To conduct a cost-effectiveness study of nasal budesonide versus surgical treatment in the management of nasal polyps. Design and methods: A decision-tree model reflecting two different treatment strategies for nasal polyps in Sweden was developed. The first strategy was initial polypectomy, performed under three different sets of circumstances: inpatient functional endoscopic surgery,
In this paper the Petersen and composition matrices that modellers are now familiar with are used as a basis to construct interfacing models between subsystems considered in wastewater treatment. Starting from continuity considerations and a set of transformation reactions between components used in the two models of the subsystems to be interfaced, a set of linear algebraic equations needs to be
A search for pair-produced charged Higgs bosons was performed in the high energy data collected by the DELPHI detector at LEP II at centre-of-mass energies from 189 GeV to 202 GeV. The three different final states, taunutaunu, c (s) over bar(c) over bars and c (s) over bar taunu were considered. New methods were applied to reject wrong hadronic jet pairings and for the tau identification, where a
A seismic approach is used to estimate the thickness and elastic stiffness constants of asphalt or concrete slabs. The overall concept of the approach utilizes the robustness of the multichannel seismic method. A multichannel-equivalent data set is compiled from multiple time series recorded from multiple hammer impacts at progressively different offsets from a fixed receiver. This multichannel si
Wave cycles, i.e. pairs of local maxima and minima, play an important role in many engineering fields. Many cycle definitions are used for specific purposes, such as crest-trough cycles in wave studies in ocean engineering and rainflow cycles for fatigue life prediction in mechanical engineering. The simplest cycle, that of a pair of local maximum and the following local minimum is also of interes
A resultant-type identity for univariate polynomials is proved and used to characterise SAGBI bases of subalgebras generated by two polynomials. A new equivalent condition, expressed in terms of the degree of a field extension, for a pair of univariate polynomials to form a SAGBI basis is derived.
This paper presents terms and definitions for capillary electromigration techniques for separation, qualitative and quantitative analysis and physico-chemical characterization. Names and descriptions for such techniques (e.g., capillary electrophoresis and capillary electrochromatography) as well as terms for the phenomenon of electroosmotic flow are included.
Background: An allogeneic antitumour effect has been reported for various cancers. We evaluated the experience of allogeneic haematopoietic stem cell transplantation (HSCT) for renal cell carcinoma (RCC) in 124 patients from 21 European centres. Patients and methods: Reduced intensity conditioning and peripheral blood stem cells from an HLA-identical sibling (n = 106), a mismatched related (n = 5)
The effect of the dominant RN− allele on rigor development, ageing and tenderness was studied in M. longissimus dorsi (LD) from 11 heterozygous carriers and five non-carriers of the RN− allele. Rigor development was followed by measurements of muscle shortening, isometric tension, pH and FOP. During ageing the myofibrillar length and Warner–Bratzler shear force were measured in the meat. Sensory a
