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Tumor cell death potentially engages with the immune system. However, the efficacy of anti-tumor chemotherapy may be limited by tumor-driven immunosuppression, e.g., through CD25(+) regulatory T cells. We addressed this question in a mouse model of mesothelioma by depleting or reconstituting CD25(+) regulatory T cells in combination with two different chemotherapeutic drugs. We found that the effi
Contributing to the design update phase of the European Spallation Source ESS-scheduled to start operation in 2019-a test beamline is under construction at the BER II research reactor at Helmholtz Zentrum Berlin (HZB). This beamline offers experimental test capabilities of instrument concepts viable for the ESS. The experiments envisaged at this dedicated beamline comprise testing of components as
The Amazon has always been a strategic region because of its rich variety in natural resources. Its global interest is spreading across levels and scales, influenced by the increasing demand for fossil fuels and biodiesel and the threat of climate change. Neoliberal practices continue privatizing and exploiting the Amazon´s resources regardless the Indigenous communities’ interests. These communit
Behavior and social interactions are key features to determine the phenotype of an organism. Observing behavioral manifestations give insides on a fundamental level of how inner mechanisms work. But how is it possible to predict behavior in a way, such that it can be quantify and analyzed? One traditional strategy is to annotate the behavior by hand. Observing the animals and making notes about th
To stay within our planet’s limits and reach the United Nation’s Sustainable Development Goals, there is an urgent need to rethink our current and dominant systems. This thesis focuses on the food system, in particular, and explores how an overarching turnaround in the way we produce and consume food has the potential to trigger and steer a greater transition towards sustainability. However, this
Background: Despite an extensive literature on treatment interventions for patients with knee osteoarthritis, studies comparing the efficacy of different exercise interventions and living the life as usual on quality of life, cartilage quality and cost-effectiveness are lacking. The aim of the present study is to compare the efficacy of two different exercise programs compared to a control group i
A search is performed for WH production with a light Higgs boson decaying to hidden-sector particles resulting in clusters of collimated electrons, known as electron-jets. The search is performed with 2.04 fb(-1) of data collected in 2011 with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at root s = 7 TeV. One event satisfying the signal selection criteria is observe
A search is presented for direct top squark pair production using events with at least two leptons including a same-flavour opposite-sign pair with invariant mass consistent with the boson mass, jets tagged as originating from -quarks and missing transverse momentum. The analysis is performed with proton-proton collision data at collected with the ATLAS detector at the LHC in 2012 corresponding to
Objective. New proposed definitions of chronic kidney disease necessitate the development and use of simple and accurate methods for estimating glomerular filtration rate (GFR). Plasma cystatin C has been shown to be a more reliable GFR marker than creatinine and formulae for estimating GFR have been reported. The purpose of this study was to validate a cystatin C-based GFR prediction equation in
Populärvetenskaplig sammanfattning Morgondagens energi Vind-, och vattenkraft tillsammans med solenergi är de enda energikällorna vi har som inte leder till avfall som ökar växthuseffekt eller avfall som vi inte kan göra oss av (från t ex kärnkraftverk). Men solpanelerna som finns idag för kommersiellt privat bruk ligger på en effektivitet kring 15%. Att utveckla nya molekyler som kan omvanlda solThe aim of the study was to theoretically investigate if a proton coupled electron transfer (PCET) was feasible for a molecular system consisting of a light harvesting complex, ruthenium(tris-2,`2-bipy)2+, with different organic moieties serving as PCET (proton coupled electron transfer) relays. These light harvesting complexes are also sometimes referred to as dyes. By studying the energy levels
The thesis studies the situation within Lund University in relation to the implementation of the European Standards and Guidelines (ESG) developed by The European Association for Quality Assurance in Higher Education (ENQA). The aim of the study is to answer the following research question “How have Lund University implemented the European Standards and Guidelines developed by The European Associa
Between 1996 and 2002, 16 patients with rheumatoid arthritis and failed total ankle prosthesis underwent tibiotalocalcaneal fusion using retrograde intramedullary nails. The functional outcome was evaluated using the AOFAS scoring system and the patients were also asked about their satisfaction. Radiographs were obtained for all 16 cases minimum 1 year after surgery. Thirteen of the 16 ankles wer
BACKGROUND: Swedish policy states that older adults should be able to age safely with continued independence and lead active lives. However, this plays out differently in different Swedish municipalities depending upon degree of demographic change, globalization, and urbanization. Internationally, older adults living in disadvantaged areas have worse physical and mental health, activity restrictio
Introduction Trastuzumab is part of the standard treatment for HER2-positive breast cancer. The aim of this study was to estimate the societal value of trastuzumab administered through subcutaneous (SC) injection compared to intravenous (IV) infusion. Methods Female patients with HER2-positive breast cancer receiving SC or IV trastuzumab were consecutively enrolled from five Swedish oncology clini
Background The contribution of modifiable risk factors to the increasing global and regional burden of stroke is unclear, but knowledge about this contribution is crucial for informing stroke prevention strategies. We used data from the Global Burden of Disease Study 2013 (GBD 2013) to estimate the population-attributable fraction (PAF) of stroke-related disability-adjusted life-years (DALYs) asso
Background. Patients use self-care to relieve symptoms of common colds, yet little is known about the prevalence and patterns across Europe. Methods/Design. In a cross-sectional study 27 primary care practices from 14 countries distributed 120 questionnaires to consecutive patients (≥18 years, any reason for consultation). A 27-item questionnaire asked for patients' self-care for their last common
Radiative lifetime measurements have been performed, with a time-resolved laser-induced fluorescence technique, for 20 odd-parity levels of La I belonging to the configurations 5d(2)6p, 5d6s6p and 4f5d6s. The new results are compared with the few experimental data available in the literature and with theoretical calculations including configuration interaction effects. The agreement theory-experim
Objective To compare the rate of prenatal diagnosis of heart malformations between two policies of screening for heart malformations. Design Randomised controlled trial. Setting Six university hospitals, two district general hospitals. Sample A total of 39 572 unselected pregnancies randomised to either policy. Methods The 12-week policy implied one routine scan at 12 weeks including measurement o
We present a qualitative physical model of the origin of two very brightUV lines of Fe II at 2507-2509 Å, present in high-resolutionspectra of gaseous condensations (blobs) close to the central star ofeta Carinae. The spectra have been obtained with the Hubble SpaceTelescope (HST). The model is based on a type of Bowen mechanism withselective photoexcitation of Fe II by a broad HLyalpha profile,ge
