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To elucidate the molecular requirements for cancer cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of the protein were produced and used for uptake experiments in MCF-7 cells. Variants with alterations in the cysteine cathepsin binding region ((Δ1-10)-, K5A-, R8G-, (R8G,L9G,V10G)-, (R8G,L9G,V10G, W106G)-, and W106G-cystatin C) were internalized to a ve
Abstract in UndeterminedVehicular communication channels are characterized by a nonstationary time-frequency-selective fading process due to rapid changes in the environment. The nonstationary fading process can be characterized by assuming local stationarity for a region with finite extent in time and frequency. For this finite region, the wide-sense stationarity and uncorrelated scattering assum
Objectives This study investigated the outcome for all patients undergoing catheter valve perforation for pulmonary atresia with intact ventricular septum (PAIVS) 21 years after the first procedure at their center. Background Catheter perforation for PAIVS is now an established procedure. However, the management of the borderline right ventricle (RV) is controversial, and there may be a place for
Forest carbon cycles play an important role in efforts to understand and mitigate climate change. Large amounts of carbon (C) are stored in deep mineral forest soils, but are often not considered in accounting for global C fluxes because mineral soil C is commonly thought to be relatively stable. We explore C fluxes associated with forest management practices by examining existing data on forest C
Wind damage is one of the most economically and ecologically significant natural disturbances in European forests, yet the cloud cover that follows major storms routinely blocks optical satellite acquisitions for weeks, precisely when rapid damage mapping is most valuable. Synthetic aperture radar (SAR) circumvents this limitation through all-weather imaging, but pixel-level windthrow detection fr
Innovation concentrations are increasingly extending beyond metropolitan cores into urban peripheries through science parks, research infrastructures, advanced manufacturing sites, and innovation districts. Yet their physical presence does not necessarily generate long-term local development capacity. Existing research has explained innovation stability largely through agglomeration, proximity, in
Traditional football analytics largely evaluates players through on-ball events such as shots, passes and dribbles, leaving the much longer periods of off-ball play poorly measured. This thesis develops a spatial framework for evaluating individual player contributions in crossing situations, where a cross is defined as an aerial or driven delivery from a wide area into the central penalty zone. T
Damaged or partially damaged pumps can cause issues that at best is an inconvenience and at worst a catastrophe. In order to prevent such issues it is necessary to catch any potential damage as early as possible. One possible solution is to use a sensor that can be placed on or near a pump in order to monitor it using audio. Audio based fault detection is still a relatively new field of research,
Therapeutic peptides are a fast-increasing segment in the pharmaceutical industry, and GLP-1 analogues stood for two out of the three most sold drugs last year, 2025. The most common production method of peptides is based on Merrifield’s discovery of solid-phase peptide synthesis (SPPS), which uses large volumes of hazardous chemicals like N,N-dimethylformamide (DMF), piperidine, and trifluoraceti
Denna studie undersöker hur rollen som kommunal beredskapssamordnare konceptualiseras i kommunala rekryteringsannonser. Genom en kvalitativ innehållsanalys av 30 annonser analyseras vilka kunskaper, kompetenser och arbetsuppgifter som tillskrivs rollen. Resultatet visar att beredskapssamordnaren framställs som en hybridroll där specialistkunskap inom civil beredskap kombineras med generella kompet
Brädspel blir alltmer populära, vilket gör det ännu viktigare att deras regelböcker går att läsa och förstå. Denna uppsats syftar till att analysera språkbruket i strategiska brädspel i förhållande till klarspråk och forskning om instruerande text, men också att undersöka spelarnas uppfattning om spelens regelböcker. Metoden för undersökningen består av en textanalys av spelen Terraforming Mars, R
Today, digital pre-distortion (DPD) is the predominant technique for linearising the power amplifiers (PAs) used in telecommunication radio transmitters. However, conventional DPD implementations rely on power-hungry digital signal processing, making energy efficiency a critical concern. Compute in-memory (CiM) architectures have previously been demonstrated to provide significant efficiency gains
This thesis investigates the application of Artificial Intelligence (AI) and Machine Learning (ML) methods to improve carbon footprint estimation for Integrated Circuit (IC) components in automotive Cost Engineering (CE). The work addresses challenges faced by electrical cost engineers at Volvo Cars: the manual, time-consuming process of collecting component specifications, and estimating Carbon D
This thesis aims to develop and evaluate a fast design and optimisation workflow for corrugated tubes used in tubular heat exchangers by combining computational fluid dynamics (CFD) simulations and machine learning. A steady-state Reynolds-averaged Navier-Stokes (RANS) model was established to simplify the simulation process and reduce computational time. Based on the selected CFD setup, a CFD dat
Bakgrund På grund av den rådande klimatkrisen måste Sverige göra omfattande klimatanpassningar för att skydda sig mot kommande och nuvarande effekter av klimatförändringarna. Ansvaret för arbetet tillfaller för det mesta Sveriges kommuner genom bland annat planmonopolet. Kommunerna kan söka finansiering för dessa typer av åtgärder genom matchade statsbidrag. Däremot är bidragsprocessen för de svenIn response to growing risks associated with climate change, Sweden must address the need for climate change adaptations. A central actor in addressing this is Swedish municipalities, due to their local planning monopoly and their ability to identify risks associated with local geographical conditions. However, studies have shown that there are several obstacles within the process of adapting to c
Det huvudsakliga syftet med denna studie var att undersöka könsbias i skattningen av ledares ledarskapsförmåga, samt undersöka om könsbias i dessa bedömningar kunde prediceras av deltagarnas grad av sexism. Totalt deltog 136 unga vuxna i Sverige (58.8% kvinnor) i vinjettstudien där de skattade ledare, utifrån en kort text, på fem dimensioner rörande ledarskapsförmåga. Sexism mättes genom Swedish MThe primary aim of this study was to investigate gender bias in the evaluation of leadership ability among leaders and to examine whether these evaluations could be predicted by the participants' degree of sexism. A sample of 136 participants (58.8% women) took part in the vignette study where they scored the leaders, from a short text, across five dimensions regarding leadership ability. Sexi
One of the greatest public health challenges of our time is mental health issues, particularly the increasing prevalence among young adults in Sweden. Meanwhile, artificial intelligence (AI), which is more accessible and widely used than ever before, is being discussed as a promising tool in mental health care. This report investigates the potential of a generative AI-based chatbot to promote ment
For multi-vehicle complex traffic scenarios in shared spaces such as intelligent intersections, safe coordination and trajectory planning is challenging due to computational complexity. To meet this challenge, we introduce a computationally efficient method for generating collision-free trajectories along predefined vehicle paths. We reformulate a constrained minimum-time trajectory planning probl
A lot of previous research has studied the effect that social capital has on trust in the police and describe a person's social network as an important part in deciding the level of social capital, but none have analyzed social relationships and interactions by itself. This study examines the association between social relationships and interactions, generalized trust and trust in the police i
