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Spinocerebellar ataxia type 3 (SCA3), caused by a CAG repeat expansion in the ataxin-3 gene (ATXN3), is characterized by neuronal polyglutamine (polyQ) ATXN3 protein aggregates. Although there is no cure for SCA3, gene-silencing approaches to reduce toxic polyQ ATXN3 showed promise in preclinical models. However, a major limitation in translating putative treatments for this rare disease to the cl
A structure determination in combination with a kinetic study of the steroid converting isozyme of horse liver alcohol dehydrogenase, SS-ADH, is presented. Kinetic parameters for the substrates, 5β-androstane-3β,17β-ol, 5β-androstane-17β-ol-3-one, ethanol, and various secondary alcohols and the corresponding ketones are compared for the SS- and EE-isozymes which differ by nine amino acid substitut
Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 microg/ml it reduced the cell survival to 1.0, 5.6 and 6.6%, respectively. T
A box graph is the intersection graph of orthogonal rectangles in the plane. We consider such basic combinatorial problems on box graphs as maximum independent set, minimum vertex cover and maximum induced subgraph with polynomial-time testable hereditary property Pi. We show that they can be exactly solved in subexponential time, more precisely, in time 2(O(rootnlog n)), by applying Miller's simp
Molecularly imprinted polymer coatings were synthesized in fused-silica capillary columns by the use of a surface-coupled radical initiator. The coatings were prepared using either toluene, dichloromethane, or acetonitrile in the prepolymerization mixtures and were 0.15-2 microm thick as determined by scanning electron microscopy. Solvent-dependent differences in appearance were observed. All the
The need to reduce CO2 emissions from fossil-fuel based power production creates the need for new power plant solutions where the CO2 is captured and stored or reused. Oxygen Transfer Membrane (OTM) is the key component of oxy-fuel combustion processes as pure oxygen is usually required to process reactions (e.g. Natural Gas Combined cycle NGCC, Pulverised Coal-fired power plants PC-plants, Integr
To fulfill increasing requirements within the manufacturing sector, highly flexible and adaptable automation systems are needed. It is desirable to have one integrated approach that stretches from the process planning phase, through the implementation phase and all the way to the phase for execution of the process control logics. One promising approach is to use the concepts of service-oriented ar
Popular Abstract in Swedish Den här avhandlingen studerar olika statistiska metoder för att utvinna information som ligger dold i en serie av tal eller andra symboler, exempelvis bokstäver. En sådan serie kan innehålla slumpmässighet eller ha vissa mätbara statistiska egenskaper, men har även ett inneboende mönster, vilket vi är intresserade av. Vi kallar vanligtvis sådana serier för signaler, ochThis thesis examines sparse statistical modeling on a range of applications in audio modeling, audio localizations, DNA sequencing, and spectroscopy. In the examined cases, the resulting estimation problems are computationally cumbersome, both as one often suffers from a lack of model order knowledge for this form of problems, but also due to the high dimensionality of the parameter spaces, which
In the water sector, there have been numerous failures in projects aiming at sustainable development and there have been some, but less numerous, examples of successes. However, the most striking observation is the near universal failure to learn from these examples. Somehow, scientists and decision makers have allowed the indications of new approaches and opportunities go undetected because they
In market-driven development of product software, a crucial decision for each candidate requirement is whether or not to select it for implementation in the next release. We present an analytical model of the requirements selection process, which is used for reasoning about decision quality. A network of queues, with two classes of jobs, models the selection of requirements of different quality. T
A compact dual-element antenna suitable for ultrawideband (UWB) MIMO operation is proposed in this work. The size of the antenna is 25 mm by 40 mm and it covers the lower UWB band of 3.15-5.15 GHz. Apart from the inherent wideband isolation obtained through the different angle and polarization characteristics in the radiation patterns of the individual elements, the gap between the two antenna ele
