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Objective: Evaluate the impact of adrenalectomy on metabolic parameters and quality of life (QoL) in patients with mild autonomous cortisol secretion (MACS). Method: A multicenter prospective randomized clinical trial compared adrenalectomy with conservative management. Metabolic parameters and QoL were assessed at baseline and after 2 years. Results: Forty-three MACS patients with a single adrena
We present the time-resolved luminescence end station developed at the FemtoMAX beamline at the MAX IV Laboratory for the studies of ultrafast energy relaxation and emission properties. The instrument consists of a temperature-controlled vacuum chamber sample environment, in which the UV–visible luminescence is collected from the point of interaction of ultrashort x-ray pulses with luminescent mat
Epilepsy affects approximately 50 million people worldwide, and over 30% of patients are considered treatment resistant to currently available anti-seizure drugs. Neuropeptide Y (NPY) has been shown to inhibit excitatory synaptic transmission in hippocampal slices from human epilepsy patients via Y2 receptors (Y2Rs), and overexpression of NPY and/or Y2R in the hippocampus reduces seizures in roden
Background: People with intellectual disabilities experience significant health inequities. Digital interventions for health promotion are rarely designed from their specific needs. This study aimed to uncover core qualities of digital interventions for health promotion by exploring factors influencing health behaviours amongst people with intellectual disabilities. Methods: This study was conduct
Introduction: Accurate and reproducible measures of factor activity are required to guide clinical decision-making following gene therapy for haemophilia B (HB). Highly significant discrepancies have been observed in measurements of various factor IX (FIX) concentrates that carry molecular modifications to extend their half-life, arguing for the need for careful analysis of new HB treatment modali
AimsDyspnoea accounts for nearly 5% of emergency department (ED) visits. Our aim was to describe the in-hospital and long-term outcomes of patients admitted to the ED for dyspnoea, based on their underlying aetiology, and to determine if prognosis varies according to the hospitalization setting.MethodsWe analyzed 18 903 consecutive patients (48% male, average age 73 years) hospitalized after an ED
Energy Management Systems (EMSs) often operate through inflexible, rule-based control systems. Model-free reinforcement learning (RL) has emerged as a promising alternative, providing adaptive and autonomous control without the need for detailed modeling. However, the complexity of operating energy systems and dynamic environmental conditions limits their practical use, with most studies relying o
BACKGROUND: We hypothesized that the main barriers to integrating exercise in routine care of patients with chronic kidney disease (CKD) were structural within European healthcare systems rather than due to resistance among healthcare professionals or patients.MATERIALS AND METHODS: This descriptive cross-sectional study used anonymized questionnaires to investigate nurses' and physicians' attitud
Background: Most multiple sclerosis (MS) patients succumb to a progressive phenotype. Continued lymphocyte activity in the brain, microglia-mediated injury, iron deposition, and oxidative stress are characteristics of progressive MS. Objective: As minocycline and hydroxychloroquine have been shown to inhibit microglia, we evaluated their effects on other outcomes relevant for progression. Methods:
Postmortem MRI allows brain anatomy to be examined at high resolution and to link pathology measures with morphometric measurements. However, automated segmentation methods for brain mapping in postmortem MRI are not well developed, primarily due to limited availability of labeled datasets, and heterogeneity in scanner hardware and acquisition protocols. In this work, we present a high-resolution
Scholte wave surveys were conducted at both the laboratory and field scales to evaluate the reliability of distributed acoustic sensing (DAS) with a fiber-optic cable resting on top of unconsolidated sedimentary deposits to determine the distribution of S-wave velocity underneath. Laboratory measurements performed in a controlled environment at the Deltares Laboratory facility demonstrated that DA
Pluvial flood mapping is a common way to identify locations at risk of being flooded in connection with an extreme short-duration rainfall. As rainfall extremes are expected to intensify in a warmer climate, more and more cities and municipalities are performing pluvial flood mapping, in Sweden and elsewhere. Often a rainfall with a return period of 100–200 years is used in the mapping, and the ma
Hydraulic balancing is key to ensure proper operation of the heating system. When the heating system is not hydraulically balanced, heat is unevenly distributed across dwellings resulting in a wide temperature spread, overheating, and consequently, wastage of energy. In this paper, we study to which extent hydraulic imbalance affects the thermal energy demand of buildings. Furthermore, key variabl
The art of medicine in the semi-urban and poorly literate medieval Nordic countries was essentially a craft. Those skilled in medicine learned their profession by being apprenticed to people who were more experienced and knowledgeable. But unlike other crafts, such as that of the potter or the carpenter, one could not practice just any way. One could not start from scratch with one’s lump of clay
INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
Bakgrund/Syfte: Inom allmänpsykiatrin i Sverige behandlas personer med komplexa psykiatriska behov. Det innebär bland annat begränsningar i att delta i vardagens aktiviteter och samhällslivet. Att få stöd med detta kan möjliggöra ett liv värt att leva trots psykisk ohälsa, i enlighet med arbetsterapi. Flexible Assertive Community Treatment (FACT) är en återhämtningsinriktad integrerad vård- och st
INTRODUCTION: Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease-modifying treatments emerge. Speech-based digital biomarkers offer scalable options for remotely capturing speech-derived functional changes associated with early cognitive decline, but validation across real-world populations remains limited.METHODS: We evaluated the speech biomarker for cogni
