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Background: The prescribed radiation dose to patients with oropharyngeal squamous cell carcinoma (OPSCC) is standardized, even if the prognosis for individual patients may differ. Easy-at-hand pre-treatment risk stratification methods are valuable to individualize therapy. In the current study we assessed the prognostic impact of primary tumor volume for p16-positive and p16-negative tumors and in
Background: Systemic sclerosis (SSc) can lead to visible changes in appearance which could generate concerns among patients. Thus, valid questionnaires that capture these concerns are valuable to identify and communicate appearance concerns. Objective: To determine aspects of the validity and reliability of the Swedish version of the Satisfaction with Appearance scale for individuals with SSc (SWA
Background: This pilot study aims to test the usability of the iACTwithPain platform, an online ACT-based intervention for people with chronic pain, to obtain information on which intervention and usability aspects need improvement and on expected retention rates. Methods: Seventy-three Portuguese women with chronic pain were invited to complete the first three sessions of the iACTwithPain interve
We present new estimates of the living standards among the rural labouring classes in Sweden from 1750 to 1900. Starting with a database of more than 1,000 probate inventories of rural, landless and semi-landless people from the years 1750, 1800, 1850 and 1900, we study the development for crofters in particular. In a sub-sample of 120 probate inventories we map in great detail the material items
Project NLITED – New Level of Integrated Techniques for Daylighting Education - is an educational project for students and professionals. The project's objective is to create and develop an online eLearning platform with 32 eModules dedicated to daylight knowledge. The project also offers e-learners two summer school training where the theoryis put into practice. The platform was launched on Janua
Dysphagia, or difficulty swallowing, affects 10–30 % of persons above 65 years old. Texture-modified, easy-to-swallow, puree-like food in the form of timbales is usually served to this group of patients. Due to the characteristics of timbale, its appearance only remotely reminds of the original ingredients, leading to reduced appetite, reduced nutrition intake, and even malnutrition. 3D food print
In recent years there has been a renewed interest in subnational levels of governance as sites of potential and renewed ambition on climate change. One recent challenge to dominant neoliberal discourses of climate governance is legislation enacted in Wales, which places sustainable development as the central organising principle of local government. Through a Critical Discourse Analysis, supplemen
BackgroundSelf-regulation of payment disclosure by pharmaceutical industry trade groups is a major global approach to increasing transparency of financial relationships between drug companies and healthcare professionals and organisations. Nevertheless, little is known about the relative strengths and weaknesses of self-regulation across countries, especially beyond Europe. To address this gap in
Background: Quality control materials with minimal inter-assay differences and clinically relevant proportions of different molecular forms of the analyte are needed to optimize intra- and inter-laboratory accuracy and precision. Methods: We assessed if clinically relevant total prostate- specific antigen (tPSA) levels were present in seven commercially available Multi Constituent Tumor Marker Con
Background: Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in
Objectives. To design protocols for specific and quantitative immunohistochemical detection of human kallikrein 2 (hK2) using lanthanide chelate-labeled monoclonal antibodies (Mabs) and time-resolved fluorescence imaging. Methods. Anti-prostate-specific antigen (PSA) Mabs were tested in microtiterplate assays for their ability to prevent PSA from cross-reacting with the anti-hK2 Mab 6H10. Europium
The possibility of providing investigative leads when conventional DNA identification methods fail to solve a case can be of extreme relevance to law enforcement. Therefore, the forensic genetics community has focused research towards the broadened use of DNA, particularly for prediction of appearance traits, bio-geographical ancestry and age. The VISible Attributes through GEnomics (VISAGE) Conso
Naturally occurring antisense RNAs in prokaryotes are generally short, highly structured and untranslated. Stem-loops are always present, and loop regions serve as primary recognition structures in most cases. Single-stranded tails or internal unstructured regions are required for initiation of stable pairing between antisense and target RNA. Most antisense RNAs contain bulged-out nucleotides or s
Leaf mass per area (LMA) and equivalent water thickness (EWT) are key indicators providing information on plant growth status and agricultural management, and their retrieval is commonly done through radiative transfer models (RTMs) such as the PROSPECT model. However, the PROSPECT model is frequently hampered by the ill-posed problem as a consequence of measurement and model uncertainties. Here,
Since reusable launch vehicles have revolutionized access to space, space tourism has received enormous policy and research attention. However, such growth is occurring within a wider context of concerns over climate change, emissions, and space debris. Although the space industries have enormous environmental impacts, few studies have been undertaken on the sustainability of space tourism. Theref
Background: To date, anal cancer patients are treated with radiotherapy to similar volumes despite a marked difference in risk profile based on tumor location and stage. A more individualized approach to delineation of the elective clinical target volume (CTVe) could potentially provide better oncological outcomes as well as improved quality of life. The aim of the present work was to establish No
Human Resource Management research is striving to develop rigorous and actionable knowledge for today’s social and environmental global challenges. For years, academic-stakeholder collaborative knowledge creation processes have been considered as potentially rewarding ways to achieve this objective. However, applications of collaborative HRM research are still relatively sparse, as HR scholars ten
