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Grafted neurons obtained from the fetal basal forebrain can provide a functional cholinergic reinnervation of the hippocampal formation in rats with a lesion of the intrinsic septal cholinergic afferents. In the present experiments graft-derived acetylcholine release in the hippocampus was studied by microdialysis in awake rats during different types of behaviours which are known to activate the i
Syftet med forskningsrapporten är att bilda ett sammanhållet kunskapsläge över svensk gymnasial yrkesutbildning (skolförlagda yrkesprogram och lärlingsutbildning) som omfattar både forskning och regionala såväl som lokala satsningar för att stärka yrkesutbildningen. Forskningsrapporten omfattar två delar: (del 1) en kunskapssammanställning över den forskning som har bedrivits om gymnasial yrkesutb
Background: Full-term pregnancy (FTP) is associated with a reduced breast cancer (BC) risk over time, but women are at increased BC risk in the immediate years following an FTP. No large prospective studies, however, have examined whether the number and timing of pregnancies are associated with BC risk for BRCA1 and BRCA2 mutation carriers.Methods: Using weighted and time-varying Cox proportional
Objective. To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA). Methods. In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on
A detailed mapping of the dominant kinematical domains contributing to the prompt atmospheric neutrino flux at high neutrino energies is presented by studying their sensitivity to the cuts on several kinematical variables crucial for charm production in cosmic ray scattering in the atmosphere. This includes the maximal center-of-mass energy for proton-proton scattering, the longitudinal momentum f
Background: Hypofractionated radiotherapy for prostate cancer has gained increased attention due to its proposed high radiation-fraction sensitivity. Recent reports from studies comparing moderately hypofractionated and conventionally fractionated radiotherapy support the clinical use of moderate hypofractionation. To date, there are no published randomised studies on ultra-hypofractionated radiot
Charged-particle fragmentation functions for jets azimuthally balanced by a high-transverse-momentum, prompt, isolated photon are measured in 25 pb-1 of pp and 0.49 nb-1 of Pb+Pb collision data at 5.02 TeV per nucleon pair recorded with the ATLAS detector at the Large Hadron Collider. The measurements are compared to predictions of Monte Carlo generators and to measurements of inclusively selected
Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of mitochondrial and nuclear encoded subunits, redox co-factor acquisition, and correct joining of the subunits to form functional complexes. The conserved Cbp3-Cbp6 chaperone complex binds newly synthesized cytochrome b and supports the ordered acquisition of the heme co-factors. Moreover, it functions as a transla
A search is conducted for a beyond-the-Standard-Model boson using events where a Higgs boson with mass 125 GeV decays to four leptons (ℓ = e or μ). This decay is presumed to occur via an intermediate state which contains one or two on-shell, promptly decaying bosons: H → ZX/XX → 4ℓ, where X is a new vector boson Zd or pseudoscalar a with mass between 1 and 60 GeV. The search uses pp collision data
Background: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new
In the present study, wild type and three mutants of pyranose 2-oxidase (PyOx-WT, PyOx-MT1, PyOx-MT2, PyOx-MT3), which showed improved properties for D-galactose oxidation, were investigated for their oxidising ability when immobilised on graphite electrodes. Four different flexible Os polymers with formal potentials ranging between −0.140 and 0.270 V vs. Ag|AgCl0.1 M KCl were applied together wit
A palliative cancer diagnosis in a parent has a major impact on many aspects of patients’ children. This article aims to explore how doctors and social workers met children as relatives of a parent with cancer in order to understand the possibilities and difficulties in supporting children in specialised palliative homecare in Sweden. Qualitative, semi-structured interviews of doctors and social w
Occupational safety and health (OSH) is a vital part of the right to health. While the International Labor Organization (ILO) historically treated OSH as an entirely technical matter, it has increasingly been influenced by a human rights agenda. The ILO has responded by adopting and promoting a large number of international standards-in the form of conventions, recommendations, and codes of practi
In this paper, NaCl pellets are produced in-house from ordinary household salt using simple and accessible methods, for the purpose of suggesting a cost-effective and available tool for various optically stimulated luminescence dosimetry applications. First, the pellets are investigated in terms of optimal configuration by varying combinations of grain sizes and compression forces. Then, the pelle
Searches for the exclusive decays of the Higgs and Z bosons into a J/ψ, ψ(2S), or ϒ(nS) (n=1,2,3) meson and a photon are performed with a pp collision data sample corresponding to an integrated luminosity of 36.1fb−1 collected at s=13TeV with the ATLAS detector at the CERN Large Hadron Collider. No significant excess of events is observed above the expected backgrounds, and 95% confidence-level up
Despite important applications in unsteady Stokes flow, a Fredholm second kind integral equation formulation modeling the first Dirichlet problem of the modified biharmonic equation in the plane has been derived only recently. Furthermore, this formulation becomes very ill-conditioned when the boundary is not smooth, say, having corners. The present work demonstrates numerically that a method call
The rapid growth of cities requires effective management of transport demand and restructuring of transport systems to address the needs of growing urban populations in an environmentally, socially and economically sustainable way. In recent years, car sharing has emerged as an alternative to owning cars in cities, which has potential to bring environmental gains and address social considerations.
INTRODUCTION: Hip and knee osteoarthritis is a leading cause of disability worldwide. Currently, the course of deterioration in pain and physical functioning in individuals with osteoarthritis is difficult to predict. Factors such as socioeconomic status and comorbidity contribute to progression of osteoarthritis, but clear associations have not been established. There is a need for early identifi
