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Tissue factor (TF)-mediated protease activated receptor (PAR)-2 signaling is associated with a pro-migratory, invasive and pro-angiogenic phenotype in experimental models of breast cancer, and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these findings are unknown. Here, we provide first in vivo evidence of TF phosphoryl

Purpose. The overall purpose was to study whether and how persons with blindness detect warning surfaces with a long white cane in a real pedestrian environment after following a natural guidance surface to the warning surfaces. Of particular interest was the importance of kerb, depth, and structure of the warning surfaces. Method. A concurrently mixed methods approach, with a combination of obser

This paper presents direct numerical simulation studies of lean CH4/air and H-2/air flames at high Karlovitz numbers utilizing detailed chemical kinetic mechanisms. Identical Karlovitz numbers are applied to the two flames; however, as the interaction of high turbulence intensity small scale structures with the reaction zones is considered, a significant difference in the effect of the turbulence

This Letter presents a search for pair production of heavy down-type quarks decaying via b' -> Wt in the lepton + jets channel, as b'(b) over bar' -> W(-)tW(+)(t) over bar -> b (b) over barW(+)W(-)W(+)W- -> l(+/-) nu b (b) over barq (q) over barq (q) over barq ($) over barq. In addition to requiring exactly one lepton, large missing transverse momentum, and at least six jets, the invariant mass of

This study investigated the relationship between the absorbed dose to the lens of the eye and the absorbed dose at different measurement positions near the eye of interventional radiologists. It also visualised the dose distribution inside the head, both when protective eyewear were used and without such protection. The best position for an eye lens dosimeter was found to be at the side of the hea

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of TeV. The analysis is performed in the H -> gamma gamma decay channel using 20.3 fb(-1) of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assum

Results of a search for decays of massive particles to fully hadronic final states are presented. This search uses 20.3 fb(-1) of data collected by the ATLAS detector in root s = 8 TeV proton-proton collisions at the LHC. Signatures based on high jet multiplicities without requirements on the missing transverse momentum are used to search for R-parity-violating supersymmetric gluino pair productio

Adults with repaired tetralogy of Fallot and significant chronic pulmonary regurgitation are at risk for progressive right ventricular (RV) dilatation and dysfunction. The assessment of RV function is important in the management in these patients. There is still a lack of an adequate geometric model to quantify RV function by echocardiography. The myocardial performance index (MPI) is a nonvolumet

Most studies of social polygyny in birds have examined male provisioning on the basis of the number of feeding visits. This may be misleading if males compensate for infrequent visits by bringing larger prey at each visit. We investigated nestling provisioning in the socially polygynous great reed warbler, Acrocephalus arundinaceus, in south Central Sweden in 1996-1997. We collected data on rare o

Four different dispersing agents for solubilisation of single walled carbon nanotubes (SWNT) are here compared. Dispersing agents used here can be divided into the group of organic solvents (dimethylformamide and cyclohexanone) and charged polymers (Nafion and chitosan). Charged polymers are more efficient dispersing agents allowing quicker dispersion of nanotubes compared to solvents. Moreover ch

Doubly excited core-hole states of carbon monoxide in the photon energy region of 300-305 eV, i.e., directly above the C 1s ionization threshold, have been studied using both angle-resolved ion-yield and high-resolution resonant Auger spectroscopies. The leading configurations of the most prominent doubly excited Rydberg states are assigned by careful analysis of the ion-yield spectra and the fina

Polydisperse mixtures of dextran or Ficoll have been frequently used as molecular probes for studies of glomerular permselectivity because they are largely inert and not processed (reabsorbed) by the proximal tubules. However, dextrans are linear, flexible molecules, which apparently are hyperpermeable across the glomerular barrier. By contrast, the Ficoll molecule is almost spherical. Still, ther

The expression of secondary ornaments is often positively correlated with the bearer's condition. So far no study has reported on consequences of directional selection on male sexual ornaments in birds, i.e. it is unknown to what extent male sexual traits are genetically correlated and whether selection for secondary ornaments affects viability. In this study we estimate phenotypic and genotypic p

The aim of the present study was to validate a Swedish translation of the Gastrointestinal Quality of Life Index (GIQLI) questionnaire in patients with gallstone disease. Sensitivity to change, internal consistency, and test-retest stability were tested in 187 consecutive patients who underwent planned cholecystectomy. Construct validity was assessed by comparing the GIQLI score with the bodily pa

Knee kinematics after anterior cruciate ligament (ACL) reconstruction is of interest in studies evaluating the effect of training programs. Many studies have addressed knee flexion/extension but not valgus/varus movements. Considering that joint stability is a major concern in ACL reconstruction surgery, movements occurring in the frontal plane of the knee also deserve attention. Knee extensor tor

Abstract Background and ObjectiveFluorescence techniques can provide powerful noninvasive means for medical diagnosis, based on the detection of either endogenous or exogenous fluorophores. The fluorescence of δ-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has already shown promise for the diagnosis of tumors. The aim of the study was to investigate the localization of skin tumors a

We have started a systematic investigation of the radiative properties of the elements of the sixth row of the periodic table. Using a combination of experimental radiative lifetimes obtained with the time-resolved laser-induced fluorescence (LIF) technique and of theoretical branching fractions (BF) calculated with a HFR approach taking configuration interaction and core-polarization effects into