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Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited
Purpose To determine the potential association between genitourinary (GU) toxicity and planning dose-volume parameters for GU pelvic structures after high-dose intensity modulated radiation therapy in localized prostate cancer patients. Methods and Materials A total of 268 patients who underwent intensity modulated radiation therapy to a prescribed dose of 86.4 Gy in 48 fractions during June 2004-
This work presents an automated method for comprehensively analyzing EPID images acquired for quality assurance of RapidArc® treatment delivery. In-house-developed software has been used for the analysis and long-term results from measurements on three linacs are presented.
Extreme solar particle events (ESPEs) are rare and the most potent known processes of solar eruptive activity. During ESPEs, a vast amount of cosmogenic isotopes (CIs) 10Be, 36Cl, and 14C can be produced in the Earth's atmosphere and deposited in natural stratified archives. Accordingly, CI measurements in these archives allow us to evaluate particle fluxes during ESPEs. In this work, we present a
BOADICEA is a comprehensive risk prediction model for breast and/or ovarian cancer (BC/OC) and for carrying pathogenic variants (PVs) in cancer susceptibility genes. In addition to BRCA1 and BRCA2, BOADICEA version 6 includes PALB2, CHEK2, ATM, BARD1, RAD51C and RAD51D. To validate its predictions for these genes, we conducted a retrospective study including 2033 individuals counselled at clinical
Several sea duck species in Europe face dwindling population numbers with following increased conservation focus. Shot gun practices may put extra pressure on populations not only by direct hunting mortality but also crippling and lead poisoning from ingestion of pellets. In this study, we examined three sea duck species breeding in the Swedish Archipelago of the Baltic Sea by x-raying trapped inc
The COVID-19 pandemic has drawn attention to food insecurity in developed countries. Despite adequate levels of agricultural production, consumers experienced demand-induced scarcity. Understanding the effects on nutrition and the environment is limited, yet critical to informing ecologically embedded mitigation strategies. To identify mitigation strategies, we investigated wheat flour and egg ret
This is the first report comparing EULAR and national treatment recommendations for PsA patients across Europe, and the first this decade to compare ASAS-EULAR and national treatment recommendations in axSpA patients. An electronic survey was completed from October 2021–April 2022 by rheumatologists in 15 European countries. One and four countries followed all EULAR and ASAS-EULAR recommendations,
Projektet redovisas med en beskrivning och analys av arbetet med att leda ett lärarlag som här definieras som ett community of practice (Etienne Wenger 1988) med målet att genom ett sådant kollegiearbete gemensamt utveckla ett ändamålsenligt campus ethos för våra masterstudenter (Adrianna Kezar 2007). Mina erfarenheter och reflektioner kring arbetet med att leda och skapa möjligheter för samarbete
Levosimendan, an inodilatory drag discovered using troponin C as a target protein, has a cardiac effect deriving from the calcium sensitization of contractile proteins. The aim of this study was to give further evidence that levosimendan binds to cardiac troponin C and that the binding involves amino acid residues on helix ε of the N-terminal domain of this calcium-binding protein. Nine organic mo
