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The human genome encodes 13 aquaporin isoforms with characteristic substrate specificity that are expressed at specific locations throughout the body. Of these isoforms, AQPs 1-4 serve important functions in renal water reabsorption. Consequently, specific AQP inhibitors have been proposed as 'aquaretics', a new class of drugs suitable to induce diuresis without concomitant salt wasting. Furthermo
Purpose: The purpose of this paper is to investigate the thermal performance of the cooling plates with conventional straight channel and wavy channel designs. Design/methodology/approach: A three-dimensional model involving coupled fluid flow and heat transfer processes is developed to study the thermal performance of the cooling plates. The effects of wavelength and amplitude on the cooling perf
Modelling tools used in impact assessment procedures can be regarded as tools for communication between science and policy. In order to create an integrated system for modelling not only the scientific components have to be in place but also the science/policy interfaces in the assessment procedures have to be identified and their social dynamics understood.To make a system like SEAMLESS Integrate
Presenterar Crusenstolpes erfarenheter av Lund och Lunds universitet med fokus på hans samtidsroman Tvenne äktenskap (1847).
This article is contributing to the future of copyright law debate by exploring the recently harmonised originality standard in the EU copyright law and its suitability to a creative sharing community of Wikipedia. It shows that the “free creative choices” and “author’s personal” touch criteria established by the CJEU might be unsuitable not only because of practical concerns, but also because the
Myelin-sensitive quantitative (q) MRI techniques including MT (3D FLASH) and DTI (single-shot STEAM) are of growing importance to study white matter (WM) disorders in childhood. Cerebral folate transport deficiency is an inherited, treatable WM disorder with hypomyelination, developmental regression, movement disturbances, and epilepsy. One patient with this diagnosis and severe phenotype was trea
Background: Production of second-generation bioethanol and other bulk chemicals by yeast fermentation requirescells that tolerate inhibitory lignocellulosic compounds at low pH. Saccharomyces cerevisiae displays high plasticitywith regard to inhibitor tolerance, and adaptation of cell populations to process conditions is essential for reachingefficient and robust fermentations.Results: In this stu
Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure to ambient nitrogen oxides (NOx) among PE cases and normotensive controls influence DNA methylation
Aim: Early identification of patients at risk of serious adverse events (SAEs) is of vital importance, yet it remains a challenging task. We investigated the predictive power of National Early Warning Score (NEWS) 2, as compared to NEWS, among patients assessed by a Rapid response team (RRT).Methods: Prospective, observational cohort study on 898 consecutive patients assessed by the RRTs in 26 Swe
As both public and private organizations are spending resources on fostering entrepreneurship, we have witnessed the emergence of an entrepreneurship industry. Using the entrepreneurship industry in Sweden as a case and example, this chapter provides an explorative analysis the emergence, manifestations and consequences of cultural ideals within this industry. The analysis reveals how the entrepre
Gemensamt ägande av energi har funnits i Sverige i många år. Med Ren energi-paketet från EU etableras nu en lagstiftning som introducerar ”energigemenskaper” som en ny organisationsform på energimarknaden. Målet med denna rapport är att introducera energigemenskap, hur det beskrivs i Ren energi-paketet och i Energimarknadsinspektionens förslag till ny lag för Energigemenskaper i Sverige. I rapport
En ideal bild av en aktör visar på självständighet och kontroll. För organisationer i det civila samhället är frågorna om beroende och oberoende ständigt brännande. Ett nytt krav på en ”effektrapport” väcker mycken tankemöda. Ska den idéburna verksamheten börja ”mäta en massa saker” i stället för att ”jobba, jobba!”?Kapitlet redovisar en studie som sträcker s
