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Phosphate hydrolysis is ubiquitous in biology. However, despite intensive research on this class of reactions, the precise nature of the reaction mechanism remains controversial. Herein, we have examined the hydrolysis of three homologous phosphate diesters. The solvation free energy was simulated by means of either an implicit solvation model (COSMO), hybrid quantum mechanical/molecular mechanica

The vast majority of patients with pancreatic cancer present with unresectable disease and precision medicine is lagging behind. Circulating tumor DNA (ctDNA) has emerged as a promising tool, both as a proxy for tumor burden and for capturing tumor heterogeneity, but optimal gene panels and prognostic cutoffs remain to be determined. Herein, we applied ultra-deep ctDNA sequencing using a customize

The International Society for Clinical Densitometry (ISCD) has published position statements on topics relating to the use and interpretation of measurements of bone mineral density (BMD). The most recent appeared in the Journal of Clinical Densitometry (1) and was republished in the Journal of Endocrinology and Metabolism and in Osteoporosis International (2,3). The topics included the indication

Sammanfattning Överlåtelser av företag är betydelsefulla affärshändelser med förhandlingar i flera omgångar. När inget annat är avtalat tillämpas köplagen som föreskriver en plikt för köparen att undersöka målbolaget, annars riskeras rätten att kunna åberopa fel gå förlorad. Felbedömningen tar utgångspunkt i köparens befogade förväntningar på målbolaget och som fel får inte åberopas vad som borde

The phenomenon of adopting open source software development practices in a corporate environment is known by many names, one being inner source. The objective of this study is to investigate how an organization consisting of small development teams can benet from adopting inner source and assess the level of applicability. The research has been conducted as a case study at a software development c

The modelling of filtered chemical source terms remains a fundamental challenges for large eddy simulation (LES) of reacting flows, such as combustion. This study investigates various scale similarity models for predicting filtered reaction rates. The theoretical foundation of scale similarity models is reviewed, and several extensions and generalisations are proposed. These include the distinctio

We have developed a sampling method for beamline simulations for the proposed NNBAR experiment at the European Spallation Source. The method is based on probability density evaluation and duct source biasing and enables the simulations of the entire NNBAR beamline with high statistics while also preserving correlations of the neutron tracks. Future efforts will focus on employing these methods for

A new robust microphone array method to enhance speech signals generated by a moving person in a noisy environment is presented. This blind approach is based on a two-stage scheme. First, a subband time-delay estimation method is used to localize the dominant speech source. The second stage involves speech enhancement, based on the acquired spatial information, by means of a soft-constrained subba

Dual source CT framstår som ett alternativ till invasiv coronar angiografi för diagnos av kranskärlsjukdomar, då invasiva ingrepp kan innebära risk och obehag för patienten. En dual source CT maskin kan även används i dual energy mode för avbildning av myokardiets perfusion samt kranskärlens morfologi. Denna litteraturstudies syfte är att belysa teknikens möjligheter och begränsningar för patiente

INTRODUCTION In the last years a lot of researches about source separation have been realized, like extraction of a signal of interest (vocal recognition application), identification of which source gives which sound (motor engine applications) or noise source characterization (environmental application). Most of these techniques for sound source estimation use the signal-subspace approach, where

Bakgrund: Företag Green som är en svensk detaljhandelskedja har beslutat sig för att etablera ett centrallager. Enligt Abrahamsson et al. (2011) blir centrallager och distributionscenter allt vanligare bland företag inom detaljhandeln. I och med etableringen av centrallagret är Företag Green intresserade av att få djupare kunskap i hur en inköpsorganisation påverkas. Områden som de är intresserade