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Context: Low birth weight (LBW) and unhealthy diets are risk factors of metabolic disease including type 2 diabetes (T2D). Genetic, nongenetic, and epigenetic data propose a role of the key metabolic regulator peroxisome proliferator-activated receptor gamma, coactivator 1alpha (PPARGC1A) in the development of T2D. Objective: Our objective was to investigate gene expression and DNA methylation of
Background and purpose: Statin treatment may ameliorate viral infection-induced exacerbations of chronic obstructive pulmonary disease (COPD), which exhibit Th2-type bronchial inflammation. Thymic stromal lymphopoietin (TSLP), a hub cytokine switching on Th2-inflammation, is overproduced in viral and dsRNA-stimulated bronchial epithelial cells from COPD donors. Hence, TSLP may be causally involve
Objective: To develop a working model so that dispensing pharmacists, patients and medical staff can work together to identify, solve and prevent problems associated with discharge prescriptions. Method: A routine was developed for communication between pharmacists, patients and medical staff and for dispensing drugs at the bedside. Hospital medication lists and prescriptions from the pharmacy a
The ammoxidation of propane is commonly regarded as being the future route for producing acrylonitrile, and the Mo-V-Nb-Te-oxide system studied here has thus far been seen as the most promising candidate for achieving this. Yields of up to 62% have been presented very elegantly in the patent literature. A great disadvantage has been, however, that the crystalline quality of the catalyst tends to b
Our aims were to characterize familial hypercholesterolemia (FH) in a Swedish FH population and to further elucidate the clinical expression and treatment response in relation to genotype. Secondly, we wanted to identify gene variants, which may have impact on cholesterol levels in apparently healthy subjects. In the search for sequence alterations in the large LDL receptor gene we introduced and
An old building belonging to the Royal Netherlands Academy of Arts and Sciences, situated on the bank of Amsterdam's Kaisergracht canal, formed the home of a small research department specializing in the study of dialects and Dutch folk culture up until 1988. Excerpts, records, photos and drawings were collected here in these run-down premises. It was a relatively closed setting, not highly ranked
The studies presented here have shown that it is fully possible to influence energy consumption through information. An increase in the knowledge among consumers will motivate them to be more energy efficient. Since several interrelated factors are involved in this knowledge level, it is difficult to establish the individual influences but such factors as the electricity bills, electricity meterin
Nocturnal animals are said to sacrifice colour vision in favour of increased absolute sensitivity. This is true for most vertebrates that possess a dual retina with a single type of rod for colour-blind night vision and multiple types of cone for diurnal colour vision. However, among the nocturnal vertebrates, geckos are unusual because they have no rods but three cone types. Here, we show that ge
In this paper, we propose a method for selfcalibration of a robotic manipulator force observer, which fuses information from force sensors and accelerometers in order to estimate the contact force exerted by a manipulator to its environment, by means of active motion. In robotic operation, during contact transition accelerometers and force sensors play a very important role and serve to overcome m
Hereditary prostate cancer is a genetically heterogeneous disease, and so far four different susceptibility loci have been identified. Reports of associated cancers are few, and it is generally considered a sire-specific disease. However, some reports have shown an elevated risk for prostate cancer among BRCA2 mutation carriers. In this report, we present a family in which the father and four of h
BACKGROUND: The role of long-acting, inhaled beta2-agonists in treating asthma is uncertain. In a double-blind study, we evaluated the effects of adding inhaled formoterol to both lower and higher doses of the inhaled glucocorticoid budesonide. METHODS: After a four-week run-in period of treatment with budesonide (800 microg twice daily), 852 patients being treated with glucocorticoids were random
Superporous agarose beads contain both normal diffusion pores and special, very wide superpores through which part of the chromatographic flow is transported, a situation that may greatly improve the chromatographic performance. For the first time such pore flow was measured directly by following the movement of microparticles (dyed yeast cells) through superporous beads packed in a chromatographi
AIM: To examine the psychometric properties of a modified version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), for a cardiac arrest population (IQCODE-CA).METHODS: The IQCODE-CA, a 26-item observer-reported questionnaire, was completed by informants, defined as relatives or close friends, of 268 out-of-hospital cardiac arrest (OHCA) survivors who participated in the
OBJECTIVE: To study the stent/vessel interaction and distensibility following the natural increase in vascular diameter using self-expanding and balloon-expanded stents. DESIGN: Open experimental study. SETTING: Animal laboratory, university hospital. MATERIALS AND METHODS: Eight Palmaz (P) and eight Gianturco (G) stents were transluminally placed in the infrarenal aortas of 16 pigs. Pulsatile dia
Popular Abstract in Swedish I avhandlingen argumenterar författaren för att antisemitismen var självklar i Sverige årtiondena kring sekelskiftet 1900. Antisemitismen kom till uttryck bland annat i skämtpressen. Den sistnämnda utgjorde ett viktigt inslag i såväl den framväxande masskulturen som i den politiska kulturen. Det var inte minst via skämtpressen som bilden av "juden" som en "rastyp" skildIn this dissertation it is argued that anti- Semitism was self evident in Sweden at the turn of the century 1900. Through an analysis of the comic press, which was a crucial element in mass culture and political life, the author tries to demonstrate how the everyday version of a national Swedish identity was constructed in opposition to 'The Jew'.In the decades either side of 1900, anti-Semitism h
Background: Recent genome-wide association studies (GWASs) have reported several genetic variants to be reproducibly associated with type 2 diabetes. Additional variants have also been detected from a metaanalysis of three GWASs, performed in populations of European ancestry. In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabet
Background: Knowledge is increasing about TSC-Associated Neuropsychiatric Disorders (TAND), but little is known about the potentially confounding effects of intellectual ability (IA) on the rates of TAND across age, sex, and genotype. We evaluated TAND in (a) children vs. adults, (b) males vs. females, and (c) TSC1 vs. TSC2 mutations, after stratification for levels of IA, in a large, internationa
Abstract Ky words: crack spread, mde oil, heating oil, mz,tLtivariate GARCH This thesis was performed using daily one-month future prices from 1996 until 2004; on the two assets that make up the heating oil spread i.e. crude oil and heating oil, traded on the New York mercantile exchange (NYMEX). The goal of the study was to, by designing future strategies and predicting the variance and volatilit
Background: Meniscus extrusion or hypertrophy may occur in knee osteoarthritis (OA). However, currently no data are available on the position and size of the meniscus in asymptomatic men and women with normal meniscus integrity. Methods: Three-dimensional coronal DESSwe MRIs were used to segment and quantitatively measure the size and position of the medial and lateral menisci, and their correlati
