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Post-translational modifications (PTMs) of histones including acetylation, methylation, and ubiquitination are known to be involved in the epigenetic regulation of gene expression and thus can have an important role in tumorigenesis. A number of PTMs have been linked to pancreatic cancer and are frequently studied as potential targets for cancer therapy or diagnosis. The availability of biobank-st
It has been shown that vegetation growth in semi-arid regions is important to the global terrestrial CO2 sink, which indicates the strong need for improved understanding and spatially explicit estimates of CO2 uptake (gross primary production; GPP) in semi-arid ecosystems. This study has three aims: (1) to evaluate the MOD17A2H GPP (collection 6) product against GPP based on eddy covariance (EC) f
Nematophagous fungi are parasites of nematodes, thus they have been considered and tested for biological control of parasitic nematodes, but so far with limited success. Due to the fact that the nematode cuticle is composed of proteins it is likely that fungal extracellular proteases are involved in the infection of nematodes. I have isolated a gene (designated PII) encoding an extracellular cutic
Popular Abstract in Swedish SAMMANFATTNING PÅ SVENSKA Grupp B streptokocker (GBS) Grupp B streptokocker (GBS), på latin Streptococcus agalactiae, är det vanligaste fyndet vid bakteriella infektioner, som blodförgiftning (sepsis), hjärnhinneinflammation (meningit) och lunginflammation (pneumoni) hos nyfödda barn. Sjukdomsförloppet är ofta våldsamt och livshotande. Sedan 1970-talet har det skett enABSTRACT Streptococci constitute a heterogeneous group of Gram-positive bacteria, divided into different serological groups on the basis of antigenic differences in a cell wall-associated carbohydrate. This thesis describes related surface proteins expressed by bacteria in two of these groups, the group B streptococcus (GBS) and the group A streptococcus (GAS). GBS is an encapsulated bacterium th
Popular Abstract in Swedish Typ 2 diabetes är en av världens vanligaste och snabbast ökande kroniska sjukdomar. Sjukdomen är smygande och ger ofta inledningsvis inte några särskilda symptom. Den kan därigenom förbli oupptäckt under många år. Typ 2 diabetes är dock en allvarlig sjukdom; överdödligheten i hjärt-kärlsjukdomar är fyra gånger högre hos patienter med typ 2 diabetes än hos dem som inte hTo examine cardiovascular risk factors, glycaemic control and survival in patients with type 2 diabetes mellitus (T2DM) treated in primary care, patients with T2DM and a randomised age-stratified sample of men and women aged ≥40 years living in the same community were surveyed 1992-1994. ß–Cell function and insulin resistance were estimated using the Homeostasis Model Assessment (HOMA). Vital stat
Background: In the COMET study, carvedilol improved survival compared to metoprolol tartrate in 3029 patients with NYHA II-IV heart failure and EF <35%, followed for an average of 58 months. Aims: To evaluate whether the effect on overall mortality was specific for a particular mode of death. This may help to identify the mechanism of the observed difference. Methods: Of the 1112 total deaths, 972
An activity-based vocabulary for Voice Output Communication Aids (VOCAs) was designed and evaluated through a user-centred, iterative design process, using expressions from the Gothenburg Spoken Language Corpus as well as other recorded, natural conversations. The growth and development of the vocabulary, called Phrases, was closely linked to its evaluation. The iterative design process included p
Background: Antibodies against gonadotropin-releasing hormone (GnRH) and gastrointestinal dysmotility have been found after treatment with GnRH analogues. The aim of this study was to examine the presence of such antibodies in patients with dysmotility not subjected to GnRH treatment and study the anti-GnRH antibody effect on enteric neurons viability in vitro. Methods: Plasma and sera from 3 pati
Maturation stage ameloblasts of rodents express vacuolar type-H-ATPase in the ruffled border of their plasma membrane in contact with forming dental enamel, similar to osteoclasts that resorb bone. It has been proposed that in ameloblasts this v-H-ATPase acts as proton pump to acidify the enamel space, required to complete enamel mineralization. To examine whether this v-H-ATPase in mouse amelobla
Background: The presence of enthesitis (insertional inflammation) in patients with juvenile idiopathic arthritis (JIA) is difficult to establish clinically and may influence classification and treatment of the disease. We used ultrasonography (US) and color Doppler (CD) imaging to detect enthesitis at the small and deep-seated proximal insertion of the gluteus medius fascia on the posterior iliac
Solitary fibrous tumor (SFT) is composed of spindled to ovoid cells in a patternless architecture with prominent stromal collagen and hemangiopericytoma-like vessels. Some tumors show hypercellularity, nuclear atypia, and significant mitotic activity; the latter feature in particular often portends an aggressive clinical course. SFT can sometimes be difficult to distinguish from other benign mesen
In the developed countries the public expect society to be prepared for, and step in, if something out of the ordinary happens. This public pressure appears to have increased the demand for crisis preparedness planning. In crisis management the local authority serves as the first line of defence and will more or less always be involved in responding to crises. It is therefore important to study ho
Aerosol particles in the atmosphere are important in several aspects. Some major aerosol constituents that are deposited in ecosystems are acidic or fertilisers and some minor or trace constituents are toxic. Aerosol particles are also involved in the earth’s radiation balance, both directly by scattering the sunlight and indirectly by influencing the clouds. All these effects are influenced by th
Popular Abstract in Swedish Proteiner är den huvudsakliga beståndsdelen i levande celler. Proteiner består av långa kedjor av aminosyror som sitter ihop med peptidbindningar och vecklar ihop sig till komplicerade tre dimensionella strukturer. Proteiner är involverade i praktiskt taget alla mekanismer och funktioner i cellen. När man studerar hela proteinsammansättningen i t.ex. ett organ, en speciMembrane proteins are particularly important to characterize, since they are involved in cellular processes of utmost importance in control and regulation of cells, such as transport across membranes, signal transduction and photosynthesis. The word "proteome" means all proteins expressed by a e.g. a cell or a tissue, at a certain time point and "proteomics" is the large scale study of these prote
The four surprisingly complex visual sensory organs of cubomedusae, the rhopalia, contain each six eyes of four morphologically different types, two of which are camera-type eyes. This means that the evolutionary basal nervous system of cubomedusae must process the visual signals received from a total of 24 rhopalial eyes. Since the neuronal organization of the rhopalia is obscure, the role of the
Popular Abstract in Swedish Ett ökade förbrukningen av fossila bränslen kommer att accelerera den globala uppvärmningen med oöverskådlig inverkan på oss och vår miljö. Utvecklingen av alternativa, förnybara och miljömässigt rena energiformer är därför helt essentiell. En möjlig lösning är att skapa artificiell fotosyntes, där solenergi omvandlas till bränsle (till exempel vätgas) i en process där A continuing use of fossil fuels will accelerate global warning and result in severe consequences for the environment and thereby also us. Development of alternative, sustainable and environmentally friendly energy sources is therefore crucial. One approach is to create an artificial photosynthetic system that converts sunshine into fuel (e.g. hydrogen gas) by splitting water molecules. However, i
Climate and Trade Policies in a Post-2012 World is a collection of short forward-thinking articles by leading experts on the relationship between trade and climate change policies. The idea for developing this publication was conceived at the “International Workshop on Post-2012 Climate and Trade Policies”, jointly organized in September 2008 by the United Nations Environment Programme (UNEP) and
Treatment of Parkinson's disease is complicated by a high incidence of L-DOPA-induced dyskinesias (LID). Strategies to prevent the development of LID aim at providing more stable dopaminergic stimulation. We have previously shown that deuterium substitutions in the L-DOPA molecule (D3-L-DOPA) yield dopamine that appears more resistant to enzymatic breakdown. We here investigated the effects of D3-
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in many different organ systems, activation of leukocytes and production of pro-inflammatory cytokines. The heterodimer of the cytosolic calcium-binding proteins S100A8 and S100A9 (S100A8/A9) is secreted by activated polymorphonuclear neutrophils (PMNs) and monocytes and serves as a seru
