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Most climate change scenarios predict that the variability of weather conditions will increase in coming decades. Hence, the frequency and intensity of freeze-thaw cycles in high-latitude regions are likely to increase, with concomitant effect on soil carbon biogeochemistry and associated microbial processes. To address this issue we sampled riparian soil from a Swedish boreal forest and applied t
Popular Abstract in Swedish Gliom är den vanligaste typen av hjärntumörer hos vuxna. Den mikroskopiska klassificeringen av de olika formerna av gliom är subjektiv och i vissa fall t.o.m. felaktig, vilket leder till klinisk oklarhet som kan hindra utvecklingen av terapier som riktas mot speciella egenskaper som kännetecknar speciella typer av gliom. EGFR och PDGFRA är en cellreceptor som har en cenGlioma is the most common type of primary tumor in the adult central nervous system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia development and glioma pathogenesis. In this thesis we aim to establish a glia
The global socially engaged Buddhist movement emphasis Buddhism’s engagement with society. It is a socially and politically active form of Buddhism that came into being in the twentieth century. Engaged Buddhism is a non-centralized movement that emerged in response to multiple crises in modern Asia. It has been described as a modern form of Buddhism, influenced by; modern, social, economic, psych
We report on the disruption of DNA gels cross-linked with ethylene glycol diglycidyl ether (EGDE), by sunlight exposure. The disruption over exposure time was characterized through the cumulative DNA release, the evolution in dry weight and extent of swelling, and also rheologically. The network disruption is shown to depend strongly on the degree of cross-linking density. Bovine serum albumin has
Several high resolution electrophysiological techniques such as measurements of cell membrane capacitance and amperometry are used to detect exocytotic events. A novel method was developed in this study based on the expression of P2X2 receptor channel in secreting cells. The presence of ATP sensitive channel on the cell membrane permitted the electrical detection of minute (amoles) quantities of A
To compare the long-term outcome after percutaneous coronary intervention with onew-generation' drug-eluting stents (n-DES) to oolder generation' DES (o-DES), and bare-metal stents (BMS) in a real-world population. We evaluated 94 384 consecutive stent implantations (BMS, n 64 631; o-DES, n 19 202; n-DES, n 10 551) in Sweden from November 2006 to October 2010. All cases of definite stent thrombosi
Rationale and Objectives: To investigate for differences in metabolic concentrations and ratios between patients with systemic lupus erythematosus (SLE) without (group SLE) and those with neurological symptoms (group NPSLE) compared to a healthy control (group HC) in three normal-appearing brain regions: the frontal white matter, right insula (RI), and occipital gray matter and whether changes in
The use of nonstandardized and inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising evidence-based dermatology. The Harmonising Outcome Measures for Eczema (HOME) initiative is an international multiprofessional group dedicated to atopic eczema outcomes research. In June 2011, the HOME initiative conducted a consensus study involving 43 individuals from
The hawkmoth, Manduca sexta, uses both colour and odour to find flowers when foraging for nectar. In the present study we investigated how vision and olfaction interact during learning. Manduca sexta were equally attracted to a scented blue coloured feeding target (multimodal stimulus) as to one that does not carry any scent (unimodal stimulus; visual) or to an invisible scented target (unimodal s
A novel flow-injection assay of the pathogenic enterobacteria using novel lectin-based quartz crystal microbalance (QCM) biosensor has been proposed. The biosensing part of the analytical device contained the lectins - Concanavalin A, lectins from Ulex europeus, Maackia amurensis, Lens culinaris, wheat germ agglutinin - immobilized on the gold surface of quartz crystal electrode which served as a
We have experimented with different SOM-based architectures for bio-inspired self-organizing texture and hardness perception systems. To this end we have developed a microphone based texture sensor and a hardness sensor that measures the compression of the material at a constant pressure. We have implemented and successfully tested both monomodal systems for texture and hardness perception, bimoda
Many studies have found close relationships between accessibility and various socio-economic indicators. Yet, since accessibility tends to have differentiated effects, both socially and spatially, there is a need for a model which allows for a disaggregated analysis of accessibility. The model should be possible to use in areas where road network data is incomplete. In this paper such an accessibi
Stable isotope analysis provides a powerful tool for describing the energetic pathways in a variety of ecosystems. However, isotope ratios of animal tissues can be altered by preservation methods, potentially leading to biased estimates of energy pathways when they are not taken into account. Here, we investigated the direct preservation effects of formalin, ethanol, NaCl, and drying on the delta
Background: Aquaporins, also called major intrinsic proteins (MIPs), constitute an ancient superfamily of channel proteins that facilitate the transport of water and small solutes across cell membranes. MIPs are found in almost all living organisms and are particularly abundant in plants where they form a divergent group of proteins able to transport a wide selection of substrates. Results: Analys
Spinocerebellar systems are likely to be crucial for cerebellar hallmark functions such as coordination. However, in terms of cerebellar functional analyses, these are perhaps among the least explored systems. The aim of the present study is to achieve activation of a single component of the spinocerebellar systems and to explore to what extent it can influence the spike output of granule cells, G
Popular Abstract in Swedish Ett beräkningsprogram, "FREIA", lämpligt för industriell brandriskanalys presenteras. Programmet beräknar skada på människor inom och utom en byggnad på grund av en brand eller ett utsläpp av farligt gods. För några av de i riskanalysen ingående momenten har ytterligare forskning utförts. Dessa områden är: Detektion, Släckmedel samt Brännskada på människa. Det är i dagA tool suitable for conducting industrial fire and explosion hazard analysis is presented, together with an identification of weak links in the hazard evaluation chain. For some of the weak links additional research has been carried out. The tool, "FREIA", evaluates the consequences for humans and components due to fires and accidental releases indoors and outdoors using established engineering m
Background Whether or not ankles can be replaced with reasonable safety has been the subject of debate. We present the results of a nationwide series of total ankle arthroplasties. Patients and methods All Swedish hospitals that implant or have implanted modern three-component ankle prostheses reported demographic data and date of index and revision surgery to a central register. After the data ha
Background. Increased levels of nitric oxide (NO) and the exudations of plasma proteins to the airway lumen have both been considered characteristics of airway inflammation. The aim of the present study was to investigate a possible relationship between nasal NO concentrations and acutely induced exudative inflammation of the nasal mucosa. Methods: Twelve healthy non-allergic subjects participated
Popular Abstract in Swedish Avhandlingen innehåller sju artiklar. Här presenteras ett nytt koncept för att beskriva hur fukt transporteras i porösa material. Detta bygger på införandet av en äkta flödespotential, Kirchhoff's potential. Betraktelsesättet täcker hela processen från mätning av materialdata till numerisk beräkning av fukttransport. Modeller för beräkning av fuktinträngning vid stegäThe work presented in this thesis is focused on the development of the new concept to describe isothermal moisture transport using Kirchhoff potentials. The first four papers deal with moisture transport in porous media using Kirchhoff potentials. The last three papers deal with wood. Here the theory is extended to the case of anisotropic moisture transport. The seven papers have the following con
Absolute regional cerebral blood flow (CBF) was measured in ten healthy volunteers, using both dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI) and Xe-133 SPECT within 4 h. After i.v. injection of Gd-DTPA-BMA (0.3 mmol/kg b.w.), the bolus was monitored with a Simultaneous Dual FLASH pulse sequence (1.5 s/image), providing one slice through brain tissue and a second slice thro
