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Background: Malignant melanoma is the most lethal form of skin cancer with a variable clinical course even in patients with thin melanomas and localized disease. Despite increasing insights into melanoma biology, no prognostic biomarkers have yet been incorporated into clinical protocols. Reduced expression of the RNA binding motif protein 3 (RBM3) has been shown to correlate with tumour progressi
We present the results of a search for gravitational waves associated with 154 gamma-ray bursts (GRBs) that were detected by satellite-based gamma-ray experiments in 2009-2010, during the sixth LIGO science run and the second and third Virgo science runs. We perform two distinct searches: a modeled search for coalescences of either two neutron stars or a neutron star and black hole, and a search f
Popular Abstract in Swedish Invasiv candidiasis är en allvarlig jästsvampinfektion hos redan svårt sjuka patienter och denna infektion har ökat under de senaste årtiondena. Blododling, som ärreferensdiagnostisk metod för denna infektion, har relativt låg känslighet liksom detektion av Candidaspecifika antikroppar och antigener. Utvecklingen av PCR baserade diagnostik går långsamt och det saknas stInvasive candidiasis (IC) is a serious condition and timely diagnosis with early initiation of antifungal therapy is imerative for improving outcomes. Arabinitol is a sugar alcohol with two stereoisomers, D-arabinitol (DA) and L-arabintiol (LA). Several pathogenic Candida species produce DA in vitro and high DA levels have been detected in serum and urine in patients with IC. Renal dysfunction aff
The unperturbed neutron brightness of a moderator can be defined from the number of neutrons leaving the surface of a moderator completely surrounded by a reflector. Without openings for beam extraction, it is the maximum brightness that can be theoretically achieved in a moderator. The unperturbed brightness of a cylindrical cold moderator filled with pure para-H-2 was calculated using MCNPX; the
Background Recanalization of arterial duct (AD) is rarely needed. Objective The aim of this study is to report our experience regarding the feasibility and effectiveness of arterial duct recanalization in three infants and review the relevant literature. Methods and results We report on three patients with decreased pulmonary blood flow after initial palliation. The first patient had pulmonary atr
Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. Methods and results We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholestero
Emissions and fuel economy are evaluated for two types of biofuels, namely 2-phenyl ethanol and cyclohexaneethanol. Both are derived from lignin, a form of lignocellulosic biomass. The former and latter oxygenates have an aromatic and aliphatic (i.e. saturated) ring structure, respectively. Two parametric engine sweeps were performed. First, non-EGR operation by means of varying the load via injec
We synthesized twisted bilayer graphene on single crystalline Ni(111) thin films to analyze the statistical twist angle distribution on a large scale. The twisted bilayer graphene was formed by combining two growth methods, namely the catalytic surface reaction of hydrocarbons and carbon segregation from Ni. Low energy electron diffraction (LEED) investigations directly revealed dominant twist ang
The overall aim of this research was to investigate the safety of oral care in terms of intracranial dynamics and changes in oral health during intubation and 48 hours after extubation among neuroscience intensive care unit (NICU) patients. Additional aims included comparison of a comprehensive oral care protocol (i.e., tongue scraping, electric toothbrush, non-foaming toothpaste, and application
Given that nonsuicidal self-injury (NSSI) is prevalent in adolescents, structured assessment is an essential tool to guide treatment interventions. The Functional Assessment of Self-Mutilation (FASM) is a self-report scale that assesses frequency, methods, and functions of NSSI. FASM was administered to 3,097 Swedish adolescents in a community sample. With the aim of examining the underlying facto
Understanding species’ historical ranges can provide important information for conservation planning in the face of environmental change. Cromsigt et al. (this issue) comment on our recent European bison (Bison bonasus) range reconstruction, suggesting that bison were already 8000 years ago a refugee species (i.e. restricted to marginal habitat due to past human pressure) and that species distribu
This chapter reassesses the modernization processes at work in Republican China during the Warlord period between 1911 and 1927 by focusing on corporate, public action by non-state interest groups and organizations. In particular, it looks at modes of corporate governing at the interface of business/economy and education: the realm of vocational education. The chapter examines a particularly illum
Popular Abstract in Swedish Bröstcancer är den vanligast förekommande cancerformen hos kvinnor. Under sin livstid kommer tio procent av den kvinnliga befolkningen att få bröstcancer men endast en minoritet kommer att avlida av den. Operation är den vanligaste behandlingen och kombineras oftast med strålbehandling. Armlymfödem samt nedsatt axelrörlighet och muskelstyrka är välkända sidoeffekter tilTen percent of the female population in Sweden will be diagnosed with breast cancer during their lifetime, but only a minority will die from the disease. Arm lymph oedema is a well-known complication following breast cancer treatment and the incidence varies between about 10% when axillary node dissection is performed and about 40% when axillary radiotherapy is added. The general aim of this thes
Popular Abstract in Swedish Förmågan hos levande vävnader att läka skador är en basal faktor för överlevnad och utgör grundförutsättningen för all kirurgisk verksamhet. Det finns lokala skillnader beträffande celltyper och tidsförlopp, men mycket talar för att sårläkningsprocessen är principiellt likartad i alla vävnader. Sårläkning indelas i olika faser, varav den första utgöres av en inflammatorWound healing is a multistep process with an initial inflammatory response, followed by synthesis of extracellular matrix components and finalized by a repair phase. One main goal was to determine the impact and adhesive mechanisms of neutrophil recruitment in anastomotic healing in the colon. Passive immunization against CD18 abolished anastomotic accumulation of neutrophils, whereas no effect on
Popular AbstractStudien är ett försök att analysera den sociala konstruktionen av "medievåld" i den svenska pressdebatten 1980-1995. Totalt analyserades 1029 artiklar ur sju av Sveriges största dags- och kvällstidningar. Många artiklar refererar till vetenskapliga "bevis" att våld i medierna föder faktisk aggression. En närmare analys av medieeffektforskningen avslöjar dock att det påstådda sambanThis study is an attempt to analyze the social construction of media violence in the Swedish press debate 1980-1995. Altogether, 1029 articles from seven of Sweden's biggest daily and evening papers were qualitatively analyzed. Numerous claims refer to scientific 'proof' that media violence breeds personal aggression. However, a critical examination of the media effects research reveal that the al
Popular Abstract in Swedish För analys av agroekosystems näringsämnescirkulation presenteras här en generell modell. I centrum står födoproduktionsintensitet, mänsklig bärförmåga, uthållighet och effektivitet. Modellen kan användas på system med flera markanvändningstyper och är därför lämpad för studier i olika skalor. Jämförelser av alla slags agroekosystem, oavsett tid och rum, är möjliga. OlikThis study presents a general model for analysing nutrient cycling in agroecosystems. The focus is on food production intensity, human carrying capacity, sustainability and efficiency. The model can be used on systems including different kinds of land uses, which makes it applicable for studies on different scales. Comparisons of all kinds of agroecosystems, independent of time and place, are made
Clinical bacterial pathogens front a major challenge for the clinical researchers and physicians. In particular microbial pathogens like Escherichia coli, Shigella flexneri, Klebsiella pneumonia and Salmonella enterica are apparelled with systemic machineries to bring down the human immune system as well as proliferate dramatically in a short period which in turn cause a pronounced ailment to the
Food caching is a paramount model for studying relations between cognition, brain organisation and ecology in corvids. In contrast, behaviour towards inedible objects is poorly examined and understood. We review the literature on object caching in corvids and other birds, and describe an exploratory study on object caching in ravens, New Caledonian crows and jackdaws. The captive adult birds were
The phospholipid fatty acid (PLFA) pattern of vineyard soils from the Northwest of the Iberian Peninsula was studied to identify soil factors determining the microbial community structure, with special emphasis on effects of Cu pollution and pH. A wide range of soil samples, collected from six winegrowing regions (Rias Baixas, Ribeiro, Ribeira Sacra, Monterrei, Valdeorras and Vinhos Verdes) was an
The biogeography of speciation and what can be learned about the past mode of speciation from current biogeography of sister species are recurrent problems in evolution. We used a trait- and individual-based, eco-evolutionary model to simulate adaptive radiations and recorded the geographical overlap of species during and after evolutionary branching (speciation). We compared the spatial overlap a
