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Therapeutic proteins are essential in modern medicine but are often susceptible to chemical degradation during production, transportation, and storage, which can compromise functionality and even lead to immunogenicity in patients. This study investigates how the structure of the affibody GA-Z affects its chemical stability and how glycerol stabilizes the protein against deamidation and isomerizat
Proton-translocating NAD(P)+ transhydrogenase (NNT) is highly expressed in cardiac tissue, where it physiologically supports mitochondrial NADPH production. However, under certain pathological conditions, NNT may shift toward consuming the mitochondrial NADPH pool. Although NNT has been implicated in redox homeostasis, its contribution to cardiac function during aging remains uncertain. In this st
Background: The water supply in the Gaza Strip, Palestine, has been unstable and under strain for decades, resulting in major issues with drinking water quality, reliability, and acceptability. In 2018, between 25% and 30% of Gazans did not have regular access to running water. The progressive deterioration of water infrastructure and concerns over the quality of piped water have resulted in a com
Mount Fuji, the iconic mountain of Japan, remains a young and frequently active volcano. However, despite these dangers, people have continuously lived in the landscapes surrounding Mount Fuji since the peopling of the Japanese Archipelago, approximately 38ka. In this paper we explore the geological history of Mount Fuji and use a landscape archaeology approach to reconstruct how Jomon communities
Stimuli-responsive polymers stand out for their ability to respond to small environmental changes. One of the most representative thermo-sensitive materials is poly(N-isopropyl acrylamide) (PNIPAm), which presents reversible phase transitions close to the human body temperature. However, previous studies observed that the copolymerization of NIPAm with small quantities of different monomers like a
”All min strävan under denna skoldag – som ett jordeliv utgör – har varit att så mycket som möjligt främja det mänskliga broderskapets förverkligande på vår lilla jord.”Med dessa ord sammanfattade Nelly Thüring (1875–1972) sin livsfilosofi när hon vid 94 års ålder blev intervjuad av Socialdemokratiska kvinnoförbundets tidskrift Morgonbris. Som resetalare hade hon varit med och byggt upp det nystar”All I have strived for during this school day – that an earthly life amounts to – has been to do my utmost to promote the realization of human brotherhood on our little Earth.”This is how Nelly Thüring (1875–1972), at the age of 94, summarized her philosophy of life in an interview with Morgonbris, a journal published by the Swedish Social Democratic Women’s Federation. During the 1920s, she had
Character displacement theory predicts that closely-related co-occurring species should diverge in relevant traits to reduce costly interspecific interactions such as competition or hybridization. While many studies document character shifts in sympatry, few provide corresponding evidence that these shifts are driven by the costs of co-occurrence. Black-capped (Poecile atricapillus) and mountain c
IMPORTANCE: Despite a global decline in the mortality rate of children younger than 5 years (the under-5 mortality rate), neonatal deaths continue to present a substantial challenge. The etiology behind deaths varies between the early and late neonatal periods as well as at later ages.OBJECTIVE: To decompose the under-5 mortality rate in 47 low- and middle-income countries into 8 age intervals, pr
Background: As the deadline for the Sustainable Development Goals approaches, financial protection in Cambodia remains inadequate, especially for nonpoor informal workers lacking formal social health protection coverage or access to other prepayment schemes. This exposes them to high out-of-pocket health expenditures (OOPE) and related financial hardship. To better understand the drivers behind th
Due to increasing plastic production, the continuous release of primary and secondary nanoplastic particles (NPs, <1 μm) has become an emerging contaminant in terrestrial environments. The fate and transport of NPs in subsurface environments remain poorly understood, largely due to the complex interplay of mineralogical, chemical, biological, and morphological heterogeneity. This study examines in
Objective. Prior incidence estimates of psoriatic arthritis (PsA) vary considerably. We aimed to assess the annual incidence of clinically diagnosed PsA among adults in Sweden in 2014-2016, overall and stratified by age/sex/education/geography, and to investigate potential time trends in incidence in 2006-2018. Use of disease-modifying antirheumatic drugs (DMARDs) during the 2 years after diagnosi
Anthropogenic biodiversity decline threatens the functioning of ecosystems and the many benefits they provide to humanity 1. As well as causing species losses in directly affected locations, human influence might also reduce biodiversity in relatively unmodified vegetation if far-reaching anthropogenic effects trigger local extinctions and hinder recolonization. Here we show that local plant dive
For researchers studying wildlife distributions of the past, the assignment of faunal depictions and remains to species can often present considerable challenges. Regrettably, many studies do not systematically consider all options and sources of evidence and, as a result, questionable identifications are widespread in the literature, which compromises the trustworthiness of meta-analyses of human
Background and aimStroke is a life-threatening condition requiring timely and accurate treatment. Computed tomography (CT) is widely used to detect stroke due to its accessibility, speed and diagnostic value. Spectral CT, the latest advancement in CT technology, utilizes multiple energy levels to improve tissue contrast and material differentiation. This thesis aims to evaluate how spectral recons
BACKGROUND: Preventing infection in primary sutured perineal tears after childbirth is crucial to avoid systemic antibiotic use and potential complications from poor healing. This study aimed to investigate the efficacy of an antibacterial, triclosan-coated suture (VicrylPlus ®) in reducing infection in primary sutured childbirth-related perineal tears. METHODS: The PLUS study was a single-cente
Generating electricity from solar photovoltaics (PVs) has massive potential, but realising this potential will require a genuine understanding of transaction costs associated with the adopters' acquisition of the technology. The objective of this study is thus to empirically assess the transaction costs that solar PV adopters carry when proceeding with an acquisition process. Data on transaction c
The most widely used definition of a species is that it is reproductively isolated from other populations. Yet, most species are described on the basis of morphological criteria, and reproductive isolation is seldom tested. Using the ant genus Myrmica Latreille (Hymenoptera, Formicidae) as a model, we ask whether species described as distinct based on (often subtle) morphological differences indee
Autoimmune thyroid disease (AITD) is associated with other autoimmune endocrine diseases such as type 1 diabetes (T1D) and celiac disease (CeD). Thyroid peroxidase autoantibodies (TPOA) are biomarkers of AITD but may also occur in patients with other autoimmune diseases. We examined cross-sectional correlations between TPOA and an array of immune markers in a cohort of 90 children with exclusively
The human brain is a complex and finely tuned organ, constantly monitored and maintained by its resident immune cells.Among these, microglia are the primary regulators of the brain immune environment under physiological conditions, and monocyte-derived macrophages contribute mainly to pathological states such as ischemic stroke and neuronopathic Gaucher’s disease (GD). These two diseases, although
Objective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD). Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system. Methods: This was a prospective, international, multicente
