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PURPOSE: Several studies have indicated that broad genomic characterization of childhood cancer provides diagnostically and/or therapeutically relevant information in selected high-risk cases. However, the extent to which such characterization offers clinically actionable data in a prospective broadly inclusive setting remains largely unexplored.METHODS: We implemented prospective whole-genome seq
Aims. We seek to provide 2MASS and OGLE identifications and coordinates for all stars in the finding chart published by Arp (1965, ApJ, 141, 43). This chart covers the low extinction area around NGC 6522, also known as Baade's window, at coordinates (l, b) = (1.02, -3.92). Methods. A cross correlation, using numerical techniques, was performed between a scan of the original finding chart from Arp
A one-step HPLC method was developed for the purification of protein G, a cell wall molecule from group C and G streptococci with immunoglobulin G- and albumin-binding properties. Lysed Escherichia coli bacteria infected with lambda-phages containing the protein G gene from group G streptococci were used as a starting material for the preparations. The lysate was applied to a column with immobiliz
In modern history, Sweden has experienced two major financial crises: the early 1990s and the global financial crisis in 2008. During the last decades, there has been an increased global focus on regulating and supervising banks, where Basel III is the leading framework. Today, one of the most debated issues within the global economy is Covid-19. It is uncertain how the pandemic will affect countr
Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei
Background and AimsOlder persons with problematic alcohol use vary in psychosocial functioning, age of onset for problem drinking and use of other drugs. The study measured the differential risks of all-cause, alcohol, polydrug and psychiatric-related repeated hospitalizations among older persons with problematic alcohol use.DesignA linked register-based cohort study with discontinuous multiple-fa
Natural products are compounds that exist naturally in living organisms, e.g.,plants, animal and fungi. These compounds are likely biologically active and canbe used as pharmaceuticals for various diseases. Evolution has made it possible forliving organisms to produce these natural products as a defence mechanism againstvarious threats. In most cases, the organism only produces a small amount of tThis thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. The focus of the studies was to develop an efficient andconcise strat
This chapter provides an attempt to enable a productive conversation between the budding, interdisciplinary research field of celebrity studies, humanitarianism, and activism and feminist international political economy scholarship. It focuses on the Same Sky shopping initiative – a New York-based ethical trade and shopping initiative supported by a philanthropic foundation with the same name. The
