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This thesis aimed to explore the binding pocket of galectin-8N and galectin-3C. Both structure-based drug design and fragment-based drug discovery were utilized in this project, exemplifying the benefits of the different approaches. Structural determination of the proteins in complex with both high affinity ligands, and small fragments was achieved through x-ray crystallography. The structures of
Abstract: This thesis is an attempt to evaluate the pre-Christian and Christian and cult-place continuity question. This is done by investigating intervisibility between Christian Churches and pre-Christian grave monuments within the province of Halland, Sweden. This analysis was done via large statistical GIS databases of which viewshed analysis was applied to, which in turn was then interpreted
Filmdistributionen befinner sig i en ny digital verklighet. Den snabba tekniska utveckling som har ägt rum de senaste decennierna har inneburit stora utmaningar för såväl filmindustrins affärsmodell som de upphovsrättsliga bestämmelser som reglerar skyddet för filmverk och dess upphovsmän. Ett exempel på en bestämmelse vars tillämpningsområde är oklart till följd av den nya distributionen av digitFilm distribution has found itself in a new digital reality. The swift progress of technology that has taken place during the past decades has posed major challenges for both the film industry's business model and for the copyright laws that regulate the area. An example of a regulation whose scope is unclear as a result of the new distribution of digital copies is the principle of exhaustion.
Jordabalkens felregler har genomgått lagändringar och utvecklats genom rättspraxis. I ett HD-avgörande, NJA 2007 s. 86, ansågs en säljare av fast egendom under vissa kriterier ha en upplysningsplikt för fel som omfattas av köparens undersökningsplikt, men som säljaren har vetskap om. Mot bakgrund av det tidigare rättsläget och HD:s argumentation i det enskilda fallet har domens prejudikatvärde ifrThe regulations in property law (JB 1970:994) regarding defects in real estate have undergone changes and developed through case law. In a ruling by the supreme court, NJA 2007 s. 86, a seller was considered, under certain criteria, to have a duty to disclose regarding a defect that he was aware of, although it was detectable and therefore subject to the buyer´s obligation to inspect. Because of t
When an EU MS executes a state aid recovery decision, specifically those cases regarding Advance Pricing Agreements (APAs), an economic double taxation issue and a potential TP dispute may arise, which could be generated by the need for the application of a corresponding adjustment. In any case, each jurisdiction has the discretion to determine if the application of a corresponding adjustment shou
This thesis describes the design and development of a UAV simulator application prototype, which uses augmented reality technology and runs on a tablet device. The purpose of the application is to act as a complementary educational tool for unmanned aerial vehicle (UAV) pilots in training. The field of commercial unmanned aviation is rapidly growing, and with it the need for structured and standar
The first aim of this study was to on historical background survey women's alcohol habits and especially to investigate women aged 50-59 living in the Lund area. The second aim was to increase the understanding of how women's sex role has a restrictive influence on their alcohol habits. To investigate women's alcohol habits I made two quantitative studies. From secondary data I found t
The purpose of this paper was, from a starting point of children’s own perspectives and a perspective of gender, to find out what love and relations to peers mean to children. The main questions were: What does friendship mean to children?, Are there any differences in the way boys and girls look at and handle love and relations?, In what way do children express their feelings about love and frien
The Janzen–Connell hypothesis states that seedling survival increases with distance from the parent tree, which promotes regular spacing of species within a forest and thus biodiversity. Very few studies have tested this hypothesis in tropical Africa. This paper evaluates the occurrence of Janzen-Connell effects for seedlings and adult trees of the species Cola cordifolia in a dry tropical forest
One of the major arguments made in the current boom in Haitian revolutionary studies connects today’s conditions of possibility for modern democracy and human rights to the abolition of slavery during the Haitian Revolution (1791–1804). During the last decade, however, this connection between the Haitian Revolutionary period and our own age has been questioned by an increasing number of scholars: One of the major arguments made in the current boom in Haitian revolutionary studies connects today’s conditions of possibility for modern democracy and human rights to the abolition of slavery during the Haitian Revolution (1791–1804). During the last decade, however, this connection between the Haitian Revolutionary period and our own age has been questioned by an increasing number of scholars:
The 1952 General Plan for Stockholm is often seen as Sweden’s most important postwar planning document, sketching the outlines of the social-democratic urban region. In the words of city planning director Sven Markelius, it showcased ”the possibilities for building a townscape, or a milieu, with all its components that satisfy the demands we have on urban life today”. This plan has since acquired
The leadership literature has been faulted for framing leaders (and followers) as rational and disembodied information processers. This chapter presents a review of studies that go against this tendency by focusing on how materiality, embodiment, and aesthetics are involved in leadership communication. A number of different perspectives are highlighted in relation to the three focal themes, as welThe leadership literature has been faulted for framing leaders (and followers) as rational and disembodied information processers. This chapter presents a review of studies that go against this tendency by focusing on how materiality, embodiment, and aesthetics are involved in leadership communication. A number of different perspectives are highlighted in relation to the three focal themes, as wel
Sundarban mangrove is the largest continuous mangrove forest in the world and is the habitat of an incredible amount of biodiversity. Biodiversity loss and degradation of this highly ecologically productive mangrove forest due to climate change will have a tremendous impact on the livelihood of the people living in the deltaic region. The present study was aimed to find out the dynamics of change
Det finns många teorier och mycket tidigare forskning om autonomi och professionellt handlingsutrymme, men kunskapen om i vilken utsträckning rädslan för att utsättas för arbetsrelaterat våld begränsar denna autonomi och handlingsutrymme är begränsad. Denna artikel bygger på en enkätstudie (N =1,236) och jämför svenska socialarbetares, lärares och journalisters erfarenheter av arbetsrelaterat våld
Background: Despite improvements in surgical methodologies and perioperative chemo- and radiotherapy, the prognosis for patients with esophageal and gastric cancer remains poor. Hence, there is a great need to identify complementary biomarkers for improved treatment stratification. Tumor-infiltrating immune cells have been shown to impact on outcome in many types of cancer, including gastroesophag
The risk of patients committing violence implies major challenges throughout the care process in forensic psychiatry and brings risk assessments to the fore. The aim was to explore nurses’ experiences of risk assessments for their care planning and risk management in forensic psychiatry. Data were collected through focus groups with 15 nurses. The qualitative content analysis followed a deductive
To make well-informed decisions on the implementation of solar energy on roofs within the urban environment, a new method was developed and described that could support such decision-making. This method takes both the mutual shading and shading from external objects into account. The method consists of the following six steps: 1) construction of the scene, 2) performance of annual solar irradiatioTo make well-informed decisions on the implementationof solar energy on roofs within the urban environment, anew method was developed and described that couldsupport such decision-making. This method takes both themutual shading and shading from external objects intoaccount. The method consists of the following six steps:1) construction of the scene, 2) performance of annualsolar irradiation analy
The distance of sprinklers below ceiling is of fundamental importance since it has a great influence on activation time. Accepted distances are specified in different sprinkler standards such as NFPA 13, FM 2-0 and EN 12845 for different configurations. This distance is unambiguously defined for flat smooth ceilings, but for corrugated ceilings, such as corrugated metal deck ceilings found in many
