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Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl

Floriane Baussière - PhD Candidate

My bachelor’s degree is in: Biochemistry My bachelor’s degree is from: University of Geneva I graduated year: 2017 My master’s degree is in: Organic Chemistry My master’s degree is from: Lund University I graduated year: 2019 I am now a PhD candidate in Organic Chemistry at UiT The Arctic University of Norway, where I work with photoredox catalysis (generation of radicals by irradiation with visib

https://www.kemi.lu.se/floriane-baussiere-phd-candidate - 2026-05-21

Redox chemistry of a dimanganese(II,III) complex with an unsymmetric ligand: Water binding, deprotonation and accumulative light-induced oxidation

A dinuclear manganese complex {[(Mn2L)-L-II,IIII(mu-OAc)(2)]-ClO4} has been synthesised, where L is the dianion of 2-{[bis-(pyrid-2-ylmethyl)amino]methyl}-6-{[(3,5-di-tert-butyl-2- hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl)-4-methylphenol, an unsymmetric binucleating ligand with two coordinating phenol groups. The two manganese ions, with a Mn-Mn distance of 3.498 angstrom, are bridged by the t