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Although renovation costs can lead to rent increases in energy retrofitting, it is often assumed that reductions in energy costs will counterbalance the rent increase. In Swedish multifamily housing, energy costs for heating are however generally included as a fixed component in the monthly rent, meaning that the rent increase after energy retrofitting corresponds to the net change in rent level a
Achieving CRISPR Cas9-based manipulation of mitochondrial DNA (mtDNA) has been a long-standing goal and would be of great relevance for disease modeling and for clinical applications. In this project, we aimed to deliver Cas9 into the mitochondria of human cells and analyzed Cas9-induced mtDNA cleavage and measured the resulting mtDNA depletion with multiplexed qPCR. In initial experiments, we fou
Popular Abstract in Swedish Fall och frakturer hos äldre är ett vanligt förekommande och ökande hälsoproblem, som orsakar fysiska, sociala och psykologiska problem hos den enskilde och är kostsamt för samhället. Syftet med avhandlingen är att undersöka fallolyckor bland de patienter i åldern 65-74 år som kommit till ortopedklinikens akutmottagning, att undersöka reliabiliteten beträffande gångtestFalls and fractures in older people are a common and increasing health problem which causes physical, social and psychological problems for the individual and is costly to society. The aims of this thesis were to investigate accidental falls of patients aged 65 - 74 who attended an orthopedic emergency ward, to investigate reliability of the modified figure of eight (MFE) and compare it with other
In 1985 Siegenthaler introduced the concept of correlation attacks on LFSR based stream ciphers. A few years later Meier and Staffelbach demonstrated a special technique, usually referred to as fast correlation attacks, that is very effective if the feedback polynomial has a special form, namely, if its weight is very low. Due to this seminal result, it is a well known fact that one avoids low wei
Biopharmaceuticals, of which monoclonal antibodies are a mainstay, have revolutionized healthcare by enabling treatments with high precision and efficacy. However, their established manufacturing processes, particularly the downstream process, are complex, resource-intensive, and expensive, limiting global access to these drugs. This thesis examines how a more efficient, sustainable, and thus less
Purpose: Hyperoxemia is common in patients resuscitated after out-of-hospital cardiac arrest (OHCA) admitted to the intensive care unit (ICU) and may increase the risk of mortality. However, the effect of hyperoxemia on functional outcome, specifically related to the timing of exposure to hyperoxemia, remains unclear. Methods: The secondary analysis of the Target Temperature Management 2 (TTM-2) r
Taboo obsessions are ego-dystonic, recurrent, and intrusive thoughts involving aggressive, sexual and/or religious themes, which are common in individuals with obsessive-compulsive disorder (OCD). These symptoms are often challenging to treat with traditional, exposure-based approaches. Our research group has developed and successfully piloted an Internet-delivered intervention based on the cognit
Actions in teaching at INES in response to Covid-19 related restrictions, spring 2021 Authors: INES management group, Jonathan Seaquist, Lars Eklundh, Petter Pilesjö & Ulrik Mårtensson Date: 2021-02-25 Validity: until further notice The guidelines and actions below should be followed at INES to ensure staff and student safety with regard to Covid-19 disease spread. It is the responsibility of all
År 2018 meddelade EU-domstolen förhandsavgörandet C-284/16 Achmea som kom att göra investeringstvister mellan en investerare från en EU-medlemsstat mot en annan EU-medlemsstat osäker. I domslutet konstate-rade EU-domstolen att artiklarna 267 och 344 Fördraget om Europeiska unionens funktionssätt utgjorde hinder mot en sådan skiljeklausul som fanns i ett bilateralt investeringsavtal mellan SlovakieIn 2018, the Court of Justice of the European Union (CJEU) rendered its preliminary ruling C-284/16 Achmea, making the future of investment treaty arbitration between an investor from one EU member state and another EU member state uncertain. In the judgement’s operative part, the CJEU con-cluded that articles 267 and 344 Treaty on the Functioning of the European Union precludes arbitration clause
An increasing number of companies are now publicly committing to becoming carbon neutral or achieving net-zero emissions. While most organisations will focus on preventative measures to reach their targets, climate compensation will also make up part of a company’s carbon management strategy. Initial reports indicate that corporate investments in forestry-related initiatives have significantly inc
Nanodiamonds are novel carbon nanoparticles with favorable properties for biological applications, such as low cytotoxicity and high biocompatibility. They can be used for e.g. cell tracking or drug delivery. The aim of this thesis was to examine the long-term behaviour of nanodiamonds in cells and to compare two different methods of nanodiamond administration, incubation of cells in nanodiamonds a
Popular Abstract in Swedish Under de senaste decennierna har en omfattande omstrukturering ägt rum av den psykiatriska vården. Verksamheterna vid de gamla mentalsjukhusen har avvecklats genom en omfattande nerdragning av slutenvårdplatser. Psykiatrins långtidssjuka patienter skulle återföras till det sociala liv de under lång tid varit avskärmade ifrån. I samband med omorganiseringen till den s kIn the past few decades a comprehensive restructuring of psychiatric care has taken place in Sweden. The activities of the traditional closed institutions have been curtailed through a drastic reduction in the number of beds available in such institutions. "Day treatment," has arisen as a new form of intensive outpatient care in the new, geographically localized psychiatric care of patients with l
Background The endothelial ADP receptor P2Y(1) is responsible for a large part of the reactive hyperemia following cardiac ischemia. Tissue plasminogen activator (t-PA) increases during reactive hyperemia. We postulated that the release of t-PA during reactive hyperemia could be mitigated through blocking the coronary endothelial P2Y(1) receptor. Methods t-PA was measured in peripheral arterial bl
Agriculture Development Led Industrialization (ADLI) has been government development strategy since 1990s; and its objective was to develop a market oriented modernized agriculture sector, with the development of the industry to follow this as a next development stage using the raw material from agriculture. The strategies for the agriculture development have focussed on extension and research ser
The decarbonization of the energy-intensive and natural-resourced-based industries is associated with potentially large economic costs. In this paper, I explore how decarbonization may affect the profitability and market value of these industries. I also discuss the possibility of compensating for the investment costs through higher prices and enhanced productivity. I answer these questions using
