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Drugs that antagonize D2-like receptors are effective antipsychotics, but the debilitating movement disorder side effects associated with these drugs cannot be dissociated from dopamine receptor blockade. The "atypical" antipsychotics have a lower propensity to cause extrapyramidal symptoms (EPS), but the molecular basis for this is not fully understood nor is the impact of inverse agonism upon th
This population-based case-control investigation was designed to study the importance of rheumatoid arthritis, other diseases and different types of treatment for the risk of developing multiple myeloma. In total, 275 cases with verified myeloma in northern Sweden were matched to as many control subjects. Information about different diseases, drug use, diagnostic X-ray investigations and radiother
BACKGROUND: Temporal patterns of brain interstitial amino acids after subarachnoid haemorrhage (SAH) were studied in relation to energy metabolite levels and to the severity of the initial global ischaemia as reflected by the level of consciousness at admission.METHOD: Intracerebral microdialysis was used to measure brain interstitial amino acids and the energy metabolites glucose, lactate, and py
The aim of the study was to compare protein intake and metabolism between infants from two countries given similar infant formulae but different weaning foods. Healthy Swedish and Italian infants were studied between 3 and 12 mo. Infants in both populations were assigned to 1 of 3 infant formulae, containing 13, 15 or 18/20 g l-1 of protein, given in addition to Swedish or Italian weaning foods. P
Dopamine and serotonin are two major monoamine neurotransmitters associated with Parkinson's disease (PD), but their spatial distribution and relationship to underlying functional brain architecture are not fully understood. We assessed 30 patients with PD at baseline using structural MRI, resting-state functional MRI (rs-fMRI), 11C-PE2I and 11C-DASB PET, along with comprehensive clinical evaluati
Objectives: The objective was to explore if adverse events during radical prostatectomy for prostate cancer were associated with oncological outcomes. A further objective was to identify risk factors for adverse events. Methods: A post-hoc study nested in a prospective, controlled trial of radical prostatectomy by robot assisted laparoscopic or open retropubic approach in Sweden. Adverse events du
Performing a controlled glide of an Airbus A320 following an all-engine failure at cruising altitude is a highly demanding task for pilots. This study investigates whether judgement heuristics can enhance pilot performance in managing this scenario. While the existing ALL ENG FAIL Airbus procedure provides valid guidance, it offers disconnected navigational inputs to the pilots. This simulator-bas
The compatibility and safety of contrast media injectors (CMIs) at ultra-high magnetic field strengths remains a critical challenge. This study aimed to investigate a custom-designed CMI powered by a ceramic motor in a newly developed 5T MRI environment, comparing it with a commercial CMI commonly used in a clinic. Three key performance aspects of the CMI were assessed in the 5T environment: trans
BACKGROUND: Unlike other solid organ transplants, pancreas allografts can undergo a substantial decrease in baseline volume after transplantation. This phenomenon has not been well characterized, as there are insufficient data on reliable and reproducible volume assessments. We hypothesized that characterization of pancreatic volume by means of computed tomography (CT) could be a useful method for
Background: Age-related immunosenescence, also known as ‘inflammageing’, may impact the elderly’s ability to mount immune responses against cancers and compromise the effectiveness of immune checkpoint inhibition (ICI). In this context, data on tonsillar cancer (TC), a subset of head and neck squamous cell cancer (HNSCC), are lacking. Aims/objectives: To compare the presence/distribution and featu
Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children
Climate change is greatly affecting the world’s seas in many ways, but of those particularly at risk, are inland seas such as the Baltic Sea. In spite of this though, there still remains a large gap in our understanding of how multiple stressors can change these systems over time. Therefore, as a way to assess how copepod and phytoplankton species groups are changing within the Kattegat, multideca
The aim of this study was to examine the Lessons Learned process used in the Swedish Navy and to identify which factors impacts the process of turning Lessons Identified into Lessons Learned in a positive or negative way. Qualitative methods were used, collecting data from three naval units through open interviews. Four established theories have been used throughout this study. Firstly as the basi
A global and still expanding leader in the home furnishing industry, IKEA, with its head office for development of the product range in Swedish Älmhult, wants to reach out to as many customers as possible. Cost efficiency has always been a driver, but in recent years an initiative on product availability has been launched, aiming to increase customer satisfaction. Kitchen and Dining is a Business
Artificial neural networks is a powerful tool for classifying and identifying patterns in large amounts of data. One of the possible tasks of these networks is classification of data into categories. LDMX is a fixed target experiment that is designed to search for light dark matter particles using missing energy and momentum of electrons passing through and scattering of a target. In the current d
The most prevalent joint disease in adults is osteoarthritis. The knee joint is the joint which is the most affected by osteoarthritis, with mechanical overloading being one of the causes. While no cure exists for osteoarthritis, many different treatment options are available. One alternative is to wear a knee brace on the affected leg. This aims to slow down the progression of osteoarthritis to p
