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The molecular motion in water of the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer with the nominal composition EO97PO68EO97 (F127) was investigated with the aid of pulsed field gradient nuclear magnetic resonance (PFG NMR). The signal decays in the PFG experiments have been recorded for 1 wt % F127 in the temperature range from 288 to 313 K and in the concentr
Popular Abstract in Swedish Proteinkinas C i nervcellsutveckling Under fosterutvecklingen ska en enda cell, den befruktade äggcellen, ge upphov till alla de högt specialiserade celler som människokroppen består av. Den process där omogna celler utvecklas till t.ex. nervceller, blodceller och muskelceller kallas differentiering. Det som avgör vad en speciell cell ska utvecklas till är bl.a. vilka sThe human neuroblastoma cell line SH-SY5Y can be induced to differentiate into a neuronal sympathetic phenotype after treatment with 16 nM 12-O-tetradecanoyl phorbol 13-acetate (TPA) in serum, or by a combination of the growth factors basic fibroblast growth factor and insulin-like growth factor-I (bFGF/IGF-I). SH-SY5Y cells stably transfected with TrkA, the nerve growth factor (NGF) receptor, dif
Contamination of soil and water by heavy metal ions (HMs) is a problem all over the world.The use of biological methods alone or in combination with other techniques for treatment of such polluted sites constitutes a major challenge. The present thesis summarizes work based on four basic technologies: 1) use of Sulphate Reducing Bacteria (SRBs) for production of hydrogen sulphide which is used to
Encapsulated Haemophilus influenzae type b (Hib) and non-encapsulated H. influenzae (NTHi) are important pathogens causing invasive and mucosal infections in children. A 42 kDa surface-exposed lipoprotein, protein D, has been found to be a potential virulence factor of NTHi. The gene encoding protein D (hpd) is homologous to the glpQ gene encoding glycerophosphodiester phosphodiesterase in Escheri
Arsenic enrichment of groundwater in the Red River (Song Hong) delta in Vietnam was discovered in 1998. Several studies performed in this area found concentrations of As exceeding the WHO-guideline of 10 lg/L. This study focuses on an area south of Hanoi city, Nam Du, where a new well field came into operation in 2004. The new well field is situated on the bank along the Red River in order to faci
Background: Identifying children with childhood-onset neurodevelopmental problems (NDPs, defined here as autism spectrum disorders [ASDs], attention-deficit/hyperactivity disorder [AD/HD], tic disorders [TDs], learning disorders [LDs] and development coordination disorder), using easily administered screening instruments, is a prerequisite for epidemiological research. Such instruments are also cl
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is today considered a novel specific vascular inflammatory biomarker. The general aim of this thesis was to study the role and impact of Lp-PLA2 as cardiovascular (CV) risk marker in an epidemiologic perspective. Specific aims were to explore the cross-sectional association of Lp-PLA2 with traditional CV risk factors, to asses the genetic influence
Mechanical properties and rate of ATP breakdown (JATP) have been determined in the chemically skinned guinea-pig taenia coli at 22 degrees C. The influence of varied [Ca2+], [Mg ATP] and muscle length were investigated. The shortening response after a step decrease in force (isotonic quick release) was highly curvilinear in the first 100-200 ms. This effect was shown to be a time-dependent respons
The overall aim of the work presented in this thesis was to evaluate the incidence, outcome and consequences within the 1st year of acute ACL injury of the knee. The KANON-study, a randomized controlled clinical trial comparing surgical and non-surgical treatment after acute ACL injury, was initiated and some results are included in this thesis. 642 subjects with acute knee injury were assessed in
Popular Abstract in Swedish Syftet med denna avhandling är att studera hur sagor kan förändras när de förflyttas från en miljö till en annan. Flytten kan ske på flera plan; från muntligt berättande till skriftlig text, från lantligt proletariat till urban borgerlighet. Utgångspunkt har varit sagoinsamlaren och sagoförfattarens Eva Wigström (1832-1901) som på 1880-talet vandrade Skåne runt för att The purpose of this thesis is to study how fairy tales can change when they are removed from one set of surroundings to another. This movement can occur on several levels; from an orally spoken to a written text, from a rural proletariat to an urban bourgeoisie. The point of departure has been the fairy tale collector and fairy tale writer Eva Wigström (1832-1901) who in the 1880s wandered through
Basement membranes are sheet like extracellular matrices that underlie or surround many cell types. They are crucial for key cellular events such as cell migration, proliferation, survival and differentiation. Vital components of all basement membranes are laminins, heterotrimeric combinations of different laminin chain isoforms. The different laminins and their subunits largely have a development
The effects of authentic nitric oxide (NO, 10(-6) M) and NO-donors such as sodium nitroprusside (SNP, 10(-5) M) and glyceryl trinitrate (GTN, 10(-4) M) on contractile force and free intracellular calcium level ([Ca2+],) were studied on precontracted with high potassium chloride (KCI, 70 mM) isolated rings of rat tail artery. The sensitivity of contractile myofilaments to Ca2+ was measured using ch
Background— Atrial fibrillation (AF) is heterogeneous at the clinical and molecular levels. Association studies have reported that common single-nucleotide polymorphisms in KCNE1 and SCN5A may predispose to AF. In this study, we tested the hypothesis that specific AF-associated genotypes confer variation on the appearance of AF assessed by analysis of fibrillatory rate of the atria. Methods and R
Popular Abstract in Swedish Prostata cancer är en av de vanligast förekommande cancerformerna hos män i västvärlden och den vanligaste förekommande hos män i Sverige. Årligen diagnosticeras i Sverige ungefär 6000 fall och mer än 2000 avlider. Drygt 70% av alla som drabbas är äldre än 70 år medan endast ett fåtal är yngre än 50 år. Sjukdomen ter sig mycket olika hos olika patienter. En del som drabHuman glandular kallikrein 2 (hK2) is a predominantly prostate produced protein with many similarities to prostate-specific antigen (PSA). Just like for PSA elevated levels of hK2 can be found in men with protate cancer. We created an assay where hK2 in serum could reliably and with negligible cross-reactivity with PSA, be measured down to 0.030 ng/mL. The assay measured free hK2 and hK2 complexe
Background. Compounds that block uterine oxytocin and vasopressin V1a receptors have a therapeutic potential in preterm labor and primary dysmenorrhoea. The orally active vasopressin V1a receptor antagonist, SR49059, inhibits the effect of vasopressin on human uterine activity in vivo, but the influence on the response to oxytocin is unknown. Methods. In a placebo-controlled, double-blind, parall
Background: CD4-independence has been taken as a sign of a more open envelope structure that is more accessible to neutralizing antibodies and may confer altered cell tropism. In the present study, we analyzed SIVsm isolates for CD4-independent use of CCR5, mode of CCR5-use and macrophage tropism. The isolates have been collected sequentially from 13 experimentally infected cynomolgus macaques and
As part of the Mistra Future Fashion Research Program, IVL Swedish Environmental Research Institute (IVL), the International Institute for Industrial Environmental Economics (IIIEE) and PlanMiljø have investigated policy options promoting (fiber-to-fiber) recycling of textile waste. The ambition was to contribute to and broaden the discussion regarding potential policy measures in the textile fiel
Background To monitor residual disease after treatment of high grade cervical intraepithelial neoplasia (CIN), cytology together with human papillomavirus (HPV) testing are commonly performed. Objectives To analyse the spectrum of HPV types before and after treatment. Study design This register-based study included 446 women treated for CIN2 or 3, where cytology samples had been HPV-tested before
Context: Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity. Objective: To systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these
The role of oxidants in viral diseases is fairly complex because it includes metabolic regulation both of host metabolism and viral replication. However, a role for reactive oxygen species (ROS) and reactive nitrogen species (RNS) as mediators of virus-induced lung damage is supported by studies and antioxidants can thus be expected to act at many different levels. The aim of the present pilot stu
