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BACKGROUND: Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic peptides. It is unknown if Corin loss-of-function (LOF) is causally associated with risk of coronary artery disease (CAD). METHODS: We analyzed all coding CORIN variants in an Italian case-control study of CAD. We functionally tested
Background: Artificial intelligence (AI) is about to transform medical imaging. The Research Consortium for Medical Image Analysis (RECOMIA), a not-for-profit organisation, has developed an online platform to facilitate collaboration between medical researchers and AI researchers. The aim is to minimise the time and effort researchers need to spend on technical aspects, such as transfer, display,
Background: Although effective return-to-work (RTW) interventions are not widely available for individuals with common mental disorders on sick leave, there is potential for transforming such interventions into a digital solution in an effort to make them more widely available. However, little is currently known about the viewpoints of different stakeholder groups, which are critical for successfu
Objective While the incidence of children suffering from autoimmune type 1 diabetes (T1D) is increasing in Sweden and worldwide, the underlying etiology and cellular mechanisms behind this remain unknown. The predisposition of the high-risk HLA DR-DQ genotype and as yet unknown environmental triggers lead to autoimmunity and the onset of T1D, which is preceded by islet beta-cell autoantibodies a
Rapid internationalization of European higher education has resulted in a considerable increase in the number of English-medium instruction (EMI) degree programs now implemented at all levels of instruction. While this change of medium provides increased academic opportunities for all university stakeholders, the use of English by non-native speakers for teaching and learning in non-Anglosphere co
AbstractModern medicine and health care rely on a variety of diagnostic and therapeutic equipment and methods that involve ionizing radiation. To guarantee quality and the safety of patients and staff, advanced radiation detectors and dosemeters are needed that have low energy and operate with directional independence for X-ray and γ-ray photons. Similar instruments are also of great importance fo
This thesis concerns the development of negation in the Italian L2 of a group of Swedish adults who live in Italy and acquire the language by formal and spontaneous learning. Various negative expressions and the verbal system were studied in a longitudinal analysis of a corpus with 29 recordings of seven subjects. The recordings consist mainly of spontaneous dialogue. While the development of the
Sammanfattning: Ett informationssystem är i grund och botten ett sätt att lagra och bearbeta information. Alla sådana system bygger på en informationsmodell, det vill säga en modell för hur data organiseras för att de ska gå att bearbeta och omvandla till information. Idag existerar avancerade informationssystem för att göra spatiala analyser (GIS) och för att hantera byggnader (BLM-system). För nSummary: An information system is basically a way to store and process information. All such systems are built from an information model, in essence a model for how to organize data in order to make it possible to process, thus turning it into information. Today there exist advanced information systems for performing spatial analysis (GIS) and to model buildings (BLM-systems). At present the devel
Två av de grundläggande rättigheterna är yttrandefriheten och rätten till privatliv. Respektive rättighet är skyddad i Europakonventionen enligt artikel 8 och artikel 10. Rättigheterna ska värderas lika. Rättigheterna är dock inte absoluta och undantags kan göras i lag enligt 8:2 och 10:2 om det finns ett legitimt syfte eller nödvändigt för demokratin. Rättigheter kan stå i konflikt med varandra.Two of the most fundamental rights are freedom of expression and privacy. These rights are regulated in Article 8 and Article 10 in the European Convention of Human Rights (ECHR). These two rights can be in conflict with each other. The rights are not absolute, which means that they can be intruded upon when prescribed by law, legitimate aim or when necessary in a democratic society. The intrusion
An information system is basically a way to store and process information. All such systems are built from an information model, in essence a model for how to organize data in order to make it possible to process, thus turning it into information. Today there exist advanced information systems for performing spatial analysis (GIS) and to model buildings (BLM-systems). At present the development of
Internationella organisationer är ett fenomen som vuxit fram främst på senare tid. De har blivit en naturlig del av den internationella rätten och ses som väsentliga aktörer på den internationella arenan. Ett medlemskap i en internationell organisation ger en stat flera fördelar men vanligtvis innebär det även ett bortfall av statens suveränitet som ges upp till förmån för organisationens överstatInternational organizations are a phenomenon that has developed foremost recently. They have become a natural part of international law and are viewed as essential actors on the international arena. A membership gives a state multiple benefits but usually also implicates a loss of state sovereignty in favor to the advantage of supranationalism, which sometimes prohibits the states. To manage this
De förödande konsekvenserna för ekosystemen i samband med nedslaget av en asteroid för 65 miljoner år sedan, i det som idag är Yucatanhalvön, Mexiko, kan spåras i lagerföljderna över hela världen. En hög upplösningsundersökning över krita-paleogen gränsen har utförts i två marina sekvenser - Stevns Klint och Kjølby Gaard, Dammark. Sedimenten analyserades med palynofaciesanalys, Mössbauerspektrosko
Popular Abstract in Swedish Kemisk vittring har en avgörande betydelse för hur näringsämnen frigörs, ansamlas och kan utnyttjas i mark/växtsystemet. Vittringshastigheten har därför stor betydelse för hur skogs- och jordbrukare kan optimera skogsskötseln och skördeuttaget, inom ramen för ett uthålligt skogsbruk. I avhandlingen studeras vittring av epidot och lermineral för att vidareutveckla den geChemical weathering is one of the most important processes supporting life on Earth. Chemical weathering continuously contributes macronutrients and micronutrients to the soil solution. These recycling, essential elements are used as building blocks for all organic living matter. Chemical weathering is a vital factor in the analysis and understanding of a large number of important environmental is
Popular Abstract in Swedish Personer, särskilt äldre, som vårdas på sjukhus kan under vårdtiden utveckla ett tillfälligt förvirringstillstånd (akut konfusion, ACS). Tillståndet är ofta förenat med obehag för patienten och efteråt ber de ibland vårdarna om ursäkt för sitt beteende. Det är därför angeläget att vårdarna har en uppfattning om hur de skall förhålla sig till patientens förvirrade beteenThe aims of this thesis were to investigate factors of significance for the development of acute confusional state (ACS), the confusional episodes, the lived experiences of having been confused in elderly patients admitted for emergency or elective surgery in orthopaedic care. A further aim was to investigate the nurses’ view of the ACS and the encounter with patients who developed ACS. A case stu
Eighteen healthy sedentary males took part in supervised bicycle training for 50 minutes three to five times a week. Twelve subjects (group A) trained for 6 weeks at heavy intensity, and six subjects (group B) trained for 12 weeks at moderate intensity. Maximal oxygen uptake increased by about 20% (P less than 0.01). Body weight and composition as well as diet remained unchanged. After 6 weeks pla
Unsaturated solute transport is highly variable and therefore difficult to predict. In semi-arid areas, where water resources are limited, the presence of macropores is of great importance for crop production. The bromide ion (Br-) and dye tracers are useful for studies of water movement. One approach to describe the heterogeneous solute transport is to apply the concept of fractals to a dataset.
The purpose of this paper is to determine whether the Treaty to Establish a Constitution for Europe contains the basic and essential constitutional values necessary to safeguard citizens' fundamental rights. This is a significant question since any legal instrument that claims to have constitutional values for the benefit of its citizens should contain certain elements that protect its citizen
This master thesis was partly performed as a field study in Gaborone, the capital city of Botswana, located in southern Africa. The semi-arid climate in Botswana together with a rapid financial development in the country during the last decades has increased the need for water. The last years the water situation has been strained in Gaborone, and Gaborone dam which used to be one of the city’s dri
Degrowth refers to an alternative human society which is simplistic, cooperative and opposite of current growth system which is based on overproduction and overconsumption. The current growth trend is indisputably unsustainable for the future being of the earth and its’ population. Resource depletion, land degradation and climate change have become inevitable due to growth system, overproduction a
Type 1 Diabetes (T1D) is an immune-mediated disease where the pancreatic beta cells are selectively destroyed by autoreactive CD8+ T cells. However, the triggering events that eventually leads to autoreactive CD8 T cells infiltrating the pancreatic islets and, subsequently, destroying them still needs to be unveiled. Genetic and epidemiological evidence points to a substantial influence of environ
