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In other hazardous complex socio-technical systems in society, e.g. nuclear power and aviation, systems-theoretical assumptions are considered a promising way to better understand and manage safety. In this paper, two fundamental approaches to road safety were assessed in the light of a systems theory approach. One approach, is based on a premise where individual road-users are solely responsible
Zeaxanthin is a carotenoid produced by plants and has been associated with protection of the photosynthetic machinery under light stress and, together with lutein, in protection of the central retina of the eye. Zeaxanthin levels in blood plasma have been negatively correlated to the development of AMD (age-related macular degeneration) (Gale et al, 2003). Under normal conditions, plants have a lo
Objective. To assess the impact of low-to-moderate risk prostate cancer on patients' quality of life (QoL) at diagnosis and within the first year of treatment. Subjects and Methods. Men (n = 672) aged 50-75 years with prostate cancer (Gleason score ≤7, PSA ≤20 ng/mL and clinical staging T1c-T2b) were enrolled in five European countries. Patients completed five questionnaires, including EORTC Quali
Popular Abstract in Swedish De fyra studier som ingår i denna avhandling är gjorda för att undersöka eventuella oönskade effekter av läkemedel på näthinnan. Näthinnan är en del av det centrala nervsystemet och känslig för toxiska substanser. För att skydda näthinnan så finns två barriärer – en yttre och en inre blod–näthinne- barriär. Dessa barriärer består av strukturer som håller samman celler iThe adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. Rifabutin is a broad spectrum antibiotic with known ocular adverse effects (corneal opacities, uveitis and vascular ret
Objectives: Little is known about the biological processes causing aortic aneurysm rupture. Chronic Chlomydophila pneumoniae infection has been suggested as a possible contributing factor to the development and expansion of abdominal aortic aneurysm (AAA). The importance of infection in AAA may be related to the previous pathogen burden, that is, the number of significant titres of antibodies agai
In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger pr
Popular Abstract in Swedish År 2008 insjuknade 37 156 personer i akut hjärtinfarkt i Sverige och av dessa dog 10 509 personer. Akut hjärtinfarkt är därmed den vanligaste dödsorsaken i Sverige, men även i resten av världen. Generellt sett insjuknar män ungefär 10 år tidigare än kvinnor i hjärtinfarkt och män har därför en högre total risk att insjukna, även om hjärtinfarkt är den vanligaste dödsorsThe overall aim of this thesis was to explore how the risk for AMI, and the associations between several of its risk factors, differs by gender. Information was collected from four Swedish cohorts: one patient cohort from Skara (1992-1993, n=1149) and three population-based cohorts, i.e. from Skara (1993-1994, n=1109), Vara (2001-2004, n=1811), and Skövde (2003-2005, n=1005). Participants were exa
Biological invasions often cause major perturbations in the environment and are well studied among macroorganisms. Less is known about invasion by free-living microbes. Gonyostomum semen (Raphidophyceae) is a freshwater phytoplankton species that has increased in abundance in Northern Europe since the 1980's and has expanded its habitat range. In this study, we aimed to determine the genetic popul
The recently identified phylogenetic subgroup B5 of fungal glycoside hydrolase family 18 genes encodes enzymes with mannosyl glycoprotein endo-N-acetyl-b-D-glucosaminidase (ENGase)-type activity. Intracellular ENGase activity is associated with the endoplasmic reticulum associated protein degradation pathway (ERAD) of misfolded glycoproteins, although the biological relevance in filamentous fungi
Despite evidence that both pollinators and nonpollinator agents of selection can shape the evolution of floral characters, there have been few attempts to compare the strengths and directions of selection from pollinators and other agents in the same study system. In this investigation of Leucanthemum vulgare, a self-incompatible composite known for its conspicuous white rays, I obtained data from
Background: When the same dose of iodine is given to all patients when performing abdominal computed tomography (CT) there may be a wide inter-individual variation in contrast medium (CM) enhancement of the liver. Purpose: To evaluate if any of the measures body height (BH), body mass index (BMI), lean body mass (LBM), ideal body weight (IBW), and body surface area (BSA) correlated better than bod
Aim: To investigate health-related quality of life (HRQoL) in young persons with limb reduction deficiency (LRD). Methods: One hundred and forty children with LRD aged 8-16 answered the DISABKIDS questionnaire for children with chronic health conditions. Of their parents, 137 answered a corresponding questionnaire concerning their child. Results: Compared to reference data from children with other
Disorders in the musculoskeletal system have been associated with a high physical workload as well as psychosocial and individual factors. It is however not obvious which of these factors that is most important to prevent. Musculoskeletal disorders in neck and upper extremity was assessed by interview and clinical examination in 79 teachers and 93 assisting nurses, all females. Psychosocial work e
Intraneuronal inclusions containing alpha-synuclein (a-syn) constitute one of the pathological hallmarks of Parkinson's disease (PD) and are accompanied by severe neurodegeneration of A9 dopaminergic neurons located in the substantia nigra. Although to a lesser extent, A10 dopaminergic neurons are also affected. Neurodegeneration of other neuronal populations, such as the cholinergic, serotonergic
Objectives: To study: (I) work-loss seen as sick leave and disability pension before and after the start of first anti-TNF therapy in Swedish regional and national RA cohorts; (II) baseline predictors of a good future work prognosis at diagnosis and after anti-TNF start with a special focus on the impact of the disease activity level and the disease duration at treatment start. Methods: RA patie
Huvudsyftet med detta examensarbete är att utreda huruvida det borde införas ett lagstadgat skatteavdrag för klimatkompensation i svensk skattelagstiftning. För att uppfylla detta huvud-syfte har inledningsvis det gällande rättsläget kring avdragsrätt avhandlats utifrån lagstiftning och praxis, följt av en redogörelse för rättsläget kring avdragsrätt för klimatkompensation samt det närliggande omrThe main purpose of this thesis is to analyse whether there is a need for a statutory tax deduction for carbon offsetting in Swedish tax law. In order to fulfil the main purpose of this theses, the legal position of tax deductions in Swedish law has been accounted for, both in regard to legislation and case law. Further on, the legal position of tax deductions for carbon offsetting and sponsoring
2009 infördes de första svenska reglerna kring begränsningar av rätten att göra avdrag för ränteutgifter. De svenska reglerna kring ränteavdragsbegränsningar infördes mot bakgrund av den ökning av skatteplanering som kunnat ses utnyttjas inom intressegemenskaper. Reglerna kring begränsning av avdragsrätten för ränteutgifter har sedan dess uppdaterats såväl 2013 som 2019. Samtliga av dessa regelpakIn 2009, the first Swedish rules were introduced regarding restrictions on the right to deduct interest expenses. The Swedish rules on interest deduction restrictions were introduced against the background of the increase in tax planning that could be seen to be used within communities of interest. The rules on limiting the right to deduct interest expenses have since been updated in both 2013 and
Research shows that due to the influence of New Public Management reforms in the public sector in Sweden, financial means in the care of people with disabilities has grown scarcer, while budgetary and administrative workload of managers in the field has become bigger. The aim of this study has been to examine how middle managers experience that downsizing and economic work affect their professiona
Även om Sverige anses vara ett av världens mest jämställda länder så anmäls hundratals fall av misstänkt könsdiskriminering varje år. Det svenska rättighetsskyddet utgörs till stor del av Europeiska Unionens bestämmelser som omvandlats till svensk lag som myndigheter och domstolar behöver följa. Risken finns att gravida kvinnor diskrimineras på arbetsmarknaden och därför är syftet med uppsatsen atEven though Sweden is considered to be one of the world's most equal countries, hundreds of cases of suspected gender discrimination are reported every year. The legal protection in Sweden largely consists of regulations from the European Union that have been transformed into Swedish law. There is a risk that pregnant women are discriminated against in the labour market and therefore the purpo
Palsa mires are typical wetland landscapes of the Arctic regions, consisting of mosaics of palsas (raised formations of peat and permafrost) and shallow ponds, all embedded in wet mires. These heterogeneous habitats support rich and abundant wader populations, which breed there during the short Arctic summer. Although being threatened by climate change, relatively little is known about the ecologi
