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Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation

Volatile anesthetics such as halothane efficiently inhibit nonshivering thermogenesis as well as the cellular manifestation of that phenomenon: norepinephrine-induced respiration in brown adipocytes. To identify the molecular site(s) of action of such anesthetics, we have examined the effect of halothane on the sequential intracellular steps from the interaction of norepinephrine with isolated bro

Flight kinematics of the barn swallow (Hirundo rustica) over a wide range of speeds in a wind tunnel

Two barn swallows (Hirundo rustica) flying in the Lund wind tunnel were filmed using synchronised high-speed cameras to obtain posterior, ventral and lateral views of the birds in horizontal flapping flight. We investigated wingbeat kinematics, body tilt angle, tail spread and angle of attack at speeds of 414ms-1. Wingbeat frequency showed a clear U-shaped relationship with air speed with minima a

Screening for low bone mineral density with quantitative ultrasound within the primary health care system

Objective - To screen risk groups for low bone mineral density by quantitative ultrasound in primary health care. Design - Cross-sectional. Intervention - None. Subjects - Risk categories for osteoporosis (a fragility fracture, malabsorption, immobilisation, inflammatory joint disease, glucocorticoid, fenantoin or thyroxin treatment, renal insufficiency or "miscellaneous"), 775 women and 179 men a

l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation

The emergence of levodopa (l-DOPA)-induced dyskinesia and motor fluctuations represents a major clinical problem in Parkinson's disease (PD). While it has been suggested that the daily dose of l-DOPA can play a critical role, the mechanisms linking l-DOPA dosage to the occurrence of motor complications have not yet been explored. Using an experimental model of PD we have recently demonstrated that

Gabapentin in traumatic nerve injury pain: A randomized, double-blind, placebo-controlled, cross-over, mufti-center study

A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses tip to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period.

Residue-specific pK(a) determination of lysine and arginine side chains by indirect N-15 and C-13 NMR spectroscopy: Application to apo calmodulin

Electrostatic interactions in proteins can be probed experimentally through determination of residue-specific acidity constants, We describe here triple-resonance NMR techniques for direct determination of lysine and arginine side-chain protonation states in proteins. The experiments are based on detection of nonexchangeable protons over the full range of pH and temperature and therefore are well

Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis

Neisseria meningitidis (meningococcus) is an important cause of meningitis and sepsis. Currently, there is no effective vaccine against serogroup B meningococcal infection. Host defense against neisseriae requires the complement system (C) as indicated by the fact that individuals deficient in properdin or late C components (C6-9) have an increased susceptibility to recurrent neisserial infections

Supra-and Infra-Renal Aortic Neck Diameter Increase after Endovascular Repair of a Ruptured Abdominal Aortic Aneurysm

Hypovolemia-induced hypotension may lead to an aortic diameter decrease in patients with a ruptured abdominal aortic aneurysm (rAAA). This study investigates the changes in supra-and infra-renal aortic neck diameters before and after endovascular aortic aneurysm repair (EVAR) for rAAA and the possible association with endograft apposition. A retrospective cohort study was conducted including 74 pa

Should I stay or should I… Pokémon Go? : En undersökning av svensk massmedias diskussion om det digitala spelet Pokémon Go

Since digital games entered the market they have been classified as a problematic medium, something that makes people aggressive and isolated from their surroundings. A stereotype of a white, adult male, playing alone and killing virtual people started to spread in the public. During the summer and early autumn of 2016, a new game entered the public sphere, which made people all over the world lea

Yttrandefrihetens riddare : nyhetsvärderingar och nyhetsurval i samband med nazistdemonstrationerna i Göteborg 2017

This bachelor thesis deals with the reporting around the demonstration in Gothenburg on September 30th 2017 arranged by Nordiska Motståndsrörelsen (NMR), a Nordic Neo-Nazi movement. After a cultural debate in Sweden regarding freedom of speech and the attendance of the internet based right-winged alternative media Fria Tider on Mässan Bok & Bibliotek, also known as Bokmässan, always arranged a

Psykisk ohälsa bland skolelever ur ett normkritiskt perspektiv - En intervjustudie om kopplingen mellan normavvikelse och psykisk ohälsa bland skolelever

Den psykiska ohälsan bland skolelever i de svenska grundskolorna har ökat de senaste åren vilket märks av inte minst genom flertalet rapporter och undersökningar. Alla skolor har olika förhållningssätt vid deras likabehandlingsarbete där fokus ligger på att göra så att eleverna trivs så bra som möjligt. På senare år har normkritik fått ett större inslag i detta likabehandlingsarbete vilket innebärMental unhealthiness among school students in Swedish elementary schools has increased in recent years, which is not least seen by various reports and surveys. All schools have different approaches to their equal treatment work, focusing on making the students feel as comfortable as possible. In recent years, norm criticism has gained a greater part in this equal treatment work, which means making

Z-Altman's model effectiveness in bank failure prediction-The case of European banks

The corporate bankruptcy is a significant problem for economy since it is considered as a limiting factor for economic growth. The financial crisis that broke out in USA on 2007 as a result of miscalculated subprime mortgage strategies turn into a full international banking crisis affecting successively the European banks, especially those of South European countries. Given that the role and the i

Diakon- och prästämbetena i Svenska kyrkan: En studie av likheter och skillnader vad gäller arbetsuppgifter, legitimitet och resurser

The Church of Sweden is marginalized in society and the membership of the Church is decreasing, which means that the church's economy is on the decline, but the demands on the Church by its members have not decreased. This is a comparative study that deals with the roles of deacons and priests and their contribution to the Church. The aim is to get an overview of similarities and differences i

Climate change and Atlantic cod (Gadus morhua): does the increasing temperature affect its growth rate?

Climate change and the associated temperature increments are a reality, with temperature already rising in the last century. With a changing climate dissolved oxygen levels in the water will also suffer changes. The combination of changes due to alterations in the climate affects fish stocks, through alterations in the spawning-stock biomass. One of the fish stocks that are being affected is the A

Windy Times in Emerging Economies: De-Risking Renewable Energy Investments: Case Study Vietnam

In emerging economies, high investment costs hinder fast renewable energy (RE) deployment. Compared to industrial states, higher financial costs originate mainly from investment barriers and consequently risks. Using Vietnam as a case study for emerging economies, the objective of this thesis is to identify barriers and ways to remove risks by developing a de-risking policy mix that consequently h

Antagningsordning utbildning forskarniva LU

Lunds universitet Box 117, 221 00 Lund, Medicon Village Scheeletorget 1, Telefon +46 46 222 30 32 +46 46 222 00 00 E-post cecilia.gagne@fs.lu.se Un ivers i te tss tyre lsen Antagningsordning för utbildning på forskarnivå vid Lunds universitet Denna antagningsordning är fastställd av universitetsstyrelsen 2022-06-14 och ersätter tidigare antagningsordning. Denna antagningsordning gäller vid antagni

https://www.intramed.lu.se/sites/intramed.lu.se/files/2023-06/Antagningsordning_utbildning_forskarniva_LU.pdf - 2026-06-07

Livsviktigt arbete bakom en skärm : En studie i socialt arbete om ideella tjej- och transjourares syn på sin roll som stödjare

The purpose of this study was to investigate how volunteers at young women´s and transgender empowerment centers in Sweden reason about their role and their discretion in order to better understand and problematize the responsibility of conducting social work without necessarily holding an education as a social worker. The study focuses on their supportive role in online chats with young callers w

A Part of the Air We Breathe? - Managers' Perspectives on CSR Initiatives Using the Example of the Icelandic Equal Pay Certification

In this study we have explored managers’ perceptions of the importance of Corporate Social Responsibility (CSR), and the extent to which CSR can be evaluated and promoted through third-party certifications. To understand how such certifications affect companies and their corporate governance, we have explored the Icelandic Equal Pay Certification (EPC), an example of a CSR initiative. Using ten qu

Reducing Inter-cell Interference Using Machine Learning

I det här arbetet har det undersökts hur maskininlärningstekniker kan användas för att optimera tekniker som används för att minska inter-cell interferens. Inter-cell interferens är ett fenomen som uppstår i de mobila nätverken eftersom basstationerna är uppdelade i olika celler där alla celler använder samma resurser när de sänder data till mobilanvändarna. Det kan då uppstå störningar hos mobilaOne way of meeting the increasing demand for higher data rates is by building denser cellular networks in order to maximize the use of the frequency spectrum. The denser deployment leads to an increased probability of inter-cell interference, the phenomenon where the signal quality experienced by a user served by a cell is lowered because of the transmission from neighboring cells in the network.

Autonomous Vehicle and Risk Assessment

Accidents with vehicles happen more often than they should, whether it is by road traffic accidents or maritime accidents out in the sea. One big contributing factor is human error. Distraction, influence of alcohol/drugs, carelessness and speeding are examples of factors that can lead to severe injuries for the passengers, the surrounding people and to infrastructure. By transferring human maneuv