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Purpose: Previously identified transcriptomic signatures have been based on primary and metastatic melanomas with relatively few American Joint Committee on Cancer (AJCC) stage I tumors, given difficulties in sampling small tumors. The advent of adjuvant therapies has highlighted the need for better prognostic and predictive biomarkers, especially for AJCC stage I and stage II disease. Experimenta
The traditional remote sensing ecological index (RSEI), based on principal component analysis (PCA) to integrate four evaluation indexes: greenness (NDVI), humidity (WET), dryness (NDBSI), and heat (LST), is insufficient to comprehensively consider the influence of each eco-environment evaluation index on eco-environment quality (EEQ). In this research, a new comprehensive remote sensing ecologica
High humidity, high ash content and low heating values are the major disadvantages of using lignite without ant pretreatment. High moisture content and low energy density make some of the biomass resources disadvantages in direct energy production. In this thesis, the main aims to reduce the disadvantages of both sources and obtain fuel with different structural/physical properties by hydrothermal
In this study, we investigate the valorization of 5-(hydroxymethyl)furfural (5-HMF), a versatile and pivotal renewable C6 platform chemical, into a C12 heteroaromatic triol, 5,5′-bis(hydroxymethyl)furoin (DHMF), and a C12 heteroaromatic diol, 5,5′-bis(hydroxymethyl)furil (BHMF). The carboligation of 5-HMF to DHMF is catalyzed by an N-heterocyclic carbene, 1,3,4-triphenyl-4,5-dihydro-1H-1,2,4-triaz
This study investigated the spatial dynamics of bark beetle infestations and their relationships with risk factors in south-eastern Swedish forests during the years 2018–2020, highlighting the importance of spatial heterogeneity of risk factors, particularly under climate change. First, global Random Forest (RF) models were developed to examine the relationships between bark beetle infestations an
The curve number (CN) method, developed by the Natural Resources Conservation Service (NRCS), is one of the most widely used approaches worldwide to estimate runoff from rainfall events. However, one of the remaining uncertainties in the method remains whether to apply a frequency-matched or natural data approach for computing the CN from rainfall-runoff data. To address this knowledge gap, this s
Biodiversity is increasingly negatively affected by climate warming, making this issue a major conservation concern. Many bird species respond to warming temperatures by shifting distribution ranges, but these shifts often lag behind temperature changes. Protected areas (PAs) can facilitate such shifts, but a growing body of literature suggests that not all PAs facilitate climate warming responses
The impact of cyberbullying on mental health is a significant concern among adolescents, yet there is limited research on the neurophysiological markers of cyberbullying. This study aims to address this by exploring whether resting state electroencephalography (EEG) power, among traditional frequency bands (delta, theta, alpha, beta), predicts cyberbullying experiences over time. Participants (N =
The purpose of this study was to examine how young people who have chosen not to drink alcohol experience themselves and their surroundings. The aim was to find out what role temperance plays in their perceived identity. I also wanted to find out how they experienced the views of them, temperance and the temperance movement in their surroundings. Finally, I was interested in the question about alc
Streptococcus pneumoniae is a bacterium of great global importance, responsible for more than one million deaths per year. This bacterium is commonly acquired in the first years of life and colonizes the upper respiratory tract asymptomatically by forming biofilms that persist for extended times in the nasopharynx. However, under conditions that alter the bacterial environment, such as viral infec
Challenges from infections caused by biofilms and antimicrobial resistance highlight the need for novel antimicrobials that work in conjunction with antibiotics and minimize resistance risk. In this study we investigated the composite effect of HAMLET (human alpha-lactalbumin made lethal to tumor cells), a human milk protein-lipid complex and amoxicillin on microbial ecology using an ex vivo oral
Introduction: Alzheimer's disease (AD) is characterized by accumulation of amyloid beta (Aβ) and hyperphosphorylated tau (Tau-P) in the brain. Aβ enhances the activity of kinases involved in the formation of Tau-P. Phosphorylation at Thr 181 determines the propagation of multiple tau phosphorylations. Aβ is derived from the amyloid precursor protein (APP). Cleavage of APP by β-secretase also initi
Carriers of BRCA1 germline pathogenic variants are at substantially higher risk of developing breast and ovarian cancer than the general population. Accurate identification of at-risk individuals is crucial for risk stratification and the implementation of targeted preventive and therapeutic interventions. Despite significant progress in variant classification efforts, a sizable portion of reporte
Zygaenidae, also known as burnet, forester, smoky, or leaf skeletonizer moths, are a family of mainly diurnal moths well known for their aposematic colouration and the ability to release hydrogen cyanide as a defence mechanism. So far, few attempts have been made to understand the evolutionary history of the global zygaenid fauna. Here, we inferred the most comprehensive molecular phylogeny for Zy
INTRODUCTION: Primary familial brain calcification (PFBC) is a neurodegenerative disease characterised by bilateral calcification in the brain, especially in the basal ganglia, leading to neurological and neuropsychiatric manifestations. White matter hyperintensities (WMH) have been described in patients with PFBC and pathogenic variants in the gene for platelet-derived growth factor beta polypept
With the onset of climate change, adaptive action must occur at all scales, including locally, placing increasing responsibility on the public. Effective communication strategies are essential, and adaptation games have shown potential in fostering social learning and bridging the knowledge-action gap. However, few research efforts so far give voice to participants that engage with collaborative g
Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood pressure and body mass index) are included. These modifiable risk factors promote inflammation, and inflammation is one of the biological mechanism
Transcription factors (TFs) have an important role in the regulation of the gene expression network. The role of TFs in the immune response of freshwater crayfish is poorly understood, but leveraging the regulatory mechanisms of immune response could augment the resistance against the invasive oomycete pathogen, Aphanomyces astaci. Previous studies indicated that the TFs CCAAT/enhancer-binding pro
Background: In the last decades different preclinical animal models of Parkinson's disease (PD) have been generated, aiming to mimic the progressive neuronal loss of midbrain dopaminergic (DA) cells as well as motor and non-motor impairment. Among all the available models, AAV-based models of human alpha-synuclein (h-aSYN) overexpression are promising tools for investigation of disease progression
