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CK2 is an extremely pleiotropic Ser/Thr protein kinase, responsible for the generation of a large proportion of the human phosphoproteome and implicated in a wide variety of biological functions. CK2 plays a global role as an anti-apoptotic agent, a property which is believed to partially account for the addiction of many cancer cells to high CK2 levels. To gain information about the CK2 targets w
Background: The Dachshund homolog 2 (DACH2) gene has been implicated in development of the female genital tract in mouse models and premature ovarian failure syndrome, but to date, its expression in human normal and cancerous tissue remains unexplored. Using the Human Protein Atlas as a tool for cancer biomarker discovery, DACH2 protein was found to be differentially expressed in epithelial ovaria
Long term effects after peptic ulcer surgery still exert an influence on some patient groups. Partial gastrectomy increases the risk of gastric carcinoma more than 20 years after surgery and enterogastric reflux is regarded as the main ethiological factor. Partial gastrectomy also gives increased risk of other malignancies as well as smoking related disease. Parietal cell vagotomy (PCV) is conside
Background and objectives In accordance with clinical findings, myringoscterosis develops after otitis media (OM) and paracentesis in an experimental setting. The pathogenesis of this phenomenon of calcification is poorly understood. As the calcification process and the sclerotic plaques of the drum mimics features of bone tissue, this study explores tympanic membrane calcium deposition in associa
Mice were subjected to gastrectomy (GX) or sham operation (controls). Four to six weeks later the pancreatic islets were isolated and analysed for cAMP or alternatively incubated in a Krebs-Ringer based medium in an effort to study insulin secretion and cAMP accumulation in response to glucose or the adenylate cyclase activator forskolin. Freshly isolated islets from GX mice had higher cAMP conten
The timing of the ice margin retreat of the Late Glacial Patagonian Ice Sheet (PIS) in southern Patagonia has been the object of discussion for many years. In order to resolve questions about the complex response of the PIS to past climate change, any geological interpretation and data modelling need evaluation against an absolute chronology. The aim of this project is to investigate the applicabi
Popular Abstract in Swedish Hur kommer det sig att liknande reformprogram återfinns i olika länder? Varför väljs vissa idéer framför andra? Avhandlingen syftar till att öka förståelsen av så kallad policydiffusion, spridning av olika typer av policy, och den dynamik som omgärdar spridningen. Detta görs genom att undersöka hur externa, eller utländska, idéer integreras och översätts i en ny omgivniSimilar policies may be found in different countries. This, in turn, is an indication that policies travel. But why are certain policies imitated while others are not? The author seeks to further our understanding of policy diffusion and its dynamics by investigating how foreign ideas are integrated and translated into new contexts, and how these imported ideas influence national policymaking and
Northern hemisphere peatlands play an important role in the global carbon (C) cycle, accounting for about 30% of global soil C and similar to 10-25% of global natural methane (CH4) emissions. Satellite remote sensing has the potential for extracting continuous information related to C exchange rates at regional and global extents, yet, few studies have focused on peatlands. In this study we examin
The dissertation can be divided into two parts, the first of which is a detailed analysis of three excavations concerning Mellanbyn in southern Malmö. In the second part I study the more general development of society, relating Mellanbyn to the surrounding area as well as to the region as a whole during Late Bronze Age and the Early Iron Age. The aim can be summed up as being to study the developm
Popular Abstract in Swedish Denna avhandling syftar till att belysa vilket professionskunnande som blivande lärare ges möjlighet att utveckla under sin högskoleförlagda utbildning och hur detta professionskunnande kan karaktäriseras. Detta belyses genom ett antal forskningsfrågor: Vilka olika undervisningspraktiker konstituerar den högskoleförlagda lärarutbildningen? På vilket sätt upprättas dessaThe starting point for this dissertation was the reform of the school system in Sweden with consequences for teachers´ work and new demands on their professional knowledge. This thesis aims to illuminate the issue of what professional knowledge student teachers are offered during their time in the university, and how this professional knowledge can be characterised. This is carried out with respec
This thesis presents a study on performance analysis and optimal design of heat exchangers and heat exchanger networks. The study includes an experimental investigation of steam condensation in plate heat exchangers, optimal design of plate heat exchangers and plate-fin heat exchangers, and optimization of heat exchanger networks. In the experimental investigation of steam condensation in plate h
Aims To compare the effect of initial monotherapy with either bisoprolot or enalapril, followed by their combination, on mortality and hospitalization in patients with mild-to-moderate CHF. Methods and results One thousand and ten patients with mild-to-moderate CHF and left ventricular ejection fraction <= 35%, without ACE-inhibitor, beta-blocker, or angiotensin-receptor-blocker therapy were rando
Popular Abstract in Swedish Cykeln som transportmedel har många fördelar för individ och samhälle. Det är ett mycket energisnålt transportmedel, det förorenar inte, bullrar inte, tar liten plats och ger dem som cyklar välbefinnande och motion. Om fler cyklade istället för att åka bil skulle detta medföra trevligare stadsmiljöer. Ökad cykling hade också kunnat bidra till en ökad folkhälsa. För närThis work presents an evaluation of bicycle lane effects on cyclist safety and the ability of bicycles to compete with car traffic. Thirteen Swedish urban streets were studied before and after bicycle lanes were introduced. Data was collected using video recordings, speed studies, road side questionnaires/interviews with cyclists/car drivers, conflict studies and accident analysis. Results showed
AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts dev
Varumärken gör det möjligt för näringsidkare att särskilja och främja sina varor och tjänster i förhållande till andra näringsidkare. Vidare identifierar varumärken varor och tjänsters ursprung, vilket gör det möjligt för konsumenter att härleda dessa, samt upprepa eller undvika köp. Detta ger i sin tur näringsidkare incitament att investera och behålla en viss kvalitetsnivå. Näringsidkare kan, blTrademarks enable companies to distinguish and promote their goods and services vis-à-vis others and identify the origin of goods and services. This enables consumers to trace them, as well as repeat or avoid purchases. Trademarks give companies the incentive to invest and maintain a certain level of quality. As an example, companies can use their trademarks to get new, and keep existing, customer
För att en person ska kunna straffas för våldtäkt enligt svensk rätt krävs det att denne har haft uppsåt till gärningen. Det innebär att personen måste ha varit medveten om alla de omständigheter som medfört att gärningen är att betrakta som en våldtäkt, exempelvis att den utsatte sov eller tvingades till de sexuella handlingarna. Detta krav på uppsåt har i ett flertal fall, där den tilltalade fri
Konkurrensklausuler i anställningsavtal avser att begränsa arbetstagares rätt att fritt konkurrera efter avslutad anställning. Uppsatsen ämnar att bedöma om 2015 års överenskommelse om konkurrensklausuler är att betrakta som god sed på arbetsmarknaden. Denna fråga måste först besvaras innan uppsatsens huvudfråga kan besvaras, nämligen om perdurerande viten är tillåtna i konkurrensklausuler och om The purpose of a competition clause in a employment contract is to restrain the employees possibilities to compete with the former employer after he or she quits the employment. This study aims to assess if the 2015 collective agreement on competition clauses in employment contracts is to be regarded as good practice in the Swedish labor market i.e become binding on all employers and employees whe
Title: Frenemies in Business: A Case Study on the Phenomenon of Coopetition Research Question: What are drivers and challenges behind coopetition, as well as possible outcomes of the relationship? Keywords: Coopetition, Cooperation, Competition, Coopetitive Relationship, Competing Companies, Coopetitors, Coopetition Process, Drivers, Challenges, Possible Positive Outcomes, Possible Negative Out
The most widely used positioning system is Global Navigation Satellite System (GNSS), which uses traditional positioning techniques and cannot achieve satisfactory positioning performance in indoor scenarios due to Non-Line-of-Sight (NLoS) transmission. Fingerprinting is a non-traditional positioning technique that is robust to NLoS transmission in indoor scenarios. Moreover, Applying Machine Lear
The aim of this study is to investigate different types of crisis management strategies in relation to cancel culture scandals involving influencers. It is conducted through two case studies of scandals regarding Logan Pauls, one that happened in 2017 and the other one 2023. To be able to draw scientific conclusions regarding what type of strategies Logan Paul used, the study adapts three theoreti
