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Several organic cations, such as guanidino compounds and polyamines, have been found to accumulate in plasma of patients with kidney failure due to inadequate renal clearance. Here, we studied the interaction of cationic uremic toxins with renal organic cation transport in a conditionally immortalized human proximal tubule epithelial cell line (ciPTEC). Transporter activity was measured and valida
We analyze the Ce3+-Pr3+:Y2SiO5 emission spectra obtained under selective excitation of the two Ce3+ sites in Y2SiO5 and we show clear evidence of direct energy transfer from Ce3+ to Pr3+. Energy transfer microparameters were calculated from the experimental spectral overlap between the Ce3+ emission and the Pr3+ and Eu3+ absorptions from which, the transfer mechanisms Ce3+-> Pr3+ are concluded to
Service life planning and performance classification are key issues in the building sector. Well-functioning 'performance models' are absolutely essential to predict the service life and functionality of buildings, building assets, and building products overtime. Different types of performance models have been established for various building materials, but cannot necessarily transferred to wood-b
Popular Abstract in Swedish Den här avhandlingen handlar om ett protein, en receptor, kallad GPR30. GPR30 tillhör proteinfamiljen G protein-kopplade receptorer vilka är nödvändiga för att celler ska kunna kommunicera med varandra och med sin omgivning. Förenklat sätt kan de ses sitta på ytan av en cell där de väntar på att någonting ska binda till dem, vilket aktiverar receptorerna och får dem attThe large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certa
Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. The research presented in this thesis has focused on elucidating a possible involvement of the human protein alpha-1-microglobulin in the defence against pathological oxidation.
This thesis concerns the creation of Majorana bound states (MBSs) -- a type of condensed matter excitations theorized to have exotic and technologically valuable properties. In particular, they could be used to store and manipulate quantum information in a protected way, forming the building blocks of a topological quantum computer. The search for MBSs has been intense since it was realized that t
Det här examensarbetet innefattar framtagningen av ett verktyg som hjälper produktutvecklare designa ergonomiska produkter. Många produkter som idag når tillverkning, eller till och med marknaden, är inte alltid så ergonomiska som det hade kunnat önskas. Emellertid kan dessa problem förebyggas i ett tidigt skede genom väl genomtänkt utformning på produkter och adekvata ergonomiska utvärderingar. DThis master thesis consists of the development of a tool which helps product developers design ergonomic products. Many products which end up being manufactured, or end up on the market, are not as well thought out as one could wish. However, this problem can be prevented at an early stage by well thought out designs and adequate evaluations. This was a topic discussed with Avalon Innovation Techn
An important factor in preventing food waste is the ability to provide a product with a package according to its needs. The packaging material, in turn, needs to be recyclable in order to contribute to a circular use of materials rather than becoming waste. The aim of this thesis is to examine the difference between the current and future packaging material of coffee produced by Zoégas. The curren
A shortage of pediatric heart surgeons across the world limits the available surgical interventions, leading to long wait times and higher risk of mortality. The use of robotic surgery and its advantages may help address this issue, and the Collaborative Articial Intelligence Sur- gical Assistance-project is a starting point to develop an autonomous robotic surgical assistant. However, the video f
Organic contaminants are present in aquatic environments and there is a need for water treatment techniques that are both efficient and practically implementable. Antibiotics are particularly problematic organic contaminants, as insufficient removal can contribute to the spread of antibiotic resistance, which can affect essential bacteria for ecosystems and cause untreatable infections in humans.
Förenta nationernas konvention om barns rättigheter gäller sedan 1 januari 2020 som lag i Sverige. Strax därefter inleds något som kallats ”LVU-kampanjen” och övriga aktörer som demonstrerar mot socialnämndens beslut om tvångsvård av barn har på senare tid också fått stor uppmärksamhet. Jag funderar därför på om inkorporeringen av barnkonventionen har påverkat lag (1990:52) med särskilda bestämmelThe United Nations Convention on the Rights of the Child (CRC) has been in force as law since 1 January 2020 in Sweden. Soon after, something called the "LVU-campaign" was launched, and other actors who demonstrate against the social welfare board's decision on forced care of children have recently also received a lot of attention. I am therefore curious about whether the incorporati
The telecom industry falls among one of the most progressive markets that operates at the level of advanced technologies and has the fastest rate of growth all over the world, including from the perspective of 5G technology, the integration of digital products, and the constant increase in demand for broadband internet. In such a competitive environment, customer attrition has been known to be a m
As the amount of high dimensional data becomes increasingly accessible and common, the need for reliable methods to combat problems such as overfitting and multicollinearity increases. Models need to be able to manage large data sets where predictor variables often outnumber the amount of observations. In this study the frequentist and Bayesian framework is tested against each other based on three
Cultural institutions such as museums and art galleries are important agents in educating the broader public on matters where current awareness is missing, inadequate or inaccurate. In this study, I focus on one such matter, which is the knowledge regarding ethnic minorities, their history, traditions, and current challenges. My primary focus is on how cultural institutions utilise their exhibitio
The study aimed to explore users' experiences of behavioral activation therapy (BAT) in the context of cognitive behavioral therapy (CBT). Behavioral activation therapy is a therapeutic approach that emphasizes engaging in meaningful activities to counteract depression and improve overall well-being. The study was conducted through semi-structured interviews with eight participants aged betwee
I uppsatsen undersöks lagregleringen om överskottsinformation vid användning av hemliga tvångsmedel i rättegångsbalken. Överskottsinformation är information som har med annat att göra än den utredning den hemliga tvångsåtgärden användes för. Lagändringen år 2023 innebär att informationen uttryckligen får användas för ”andra ändamål” än den ursprungliga utredningen vilket kan avse brott eller helt The essay examines the legal regulation on excess information when using secret measures of surveillance in the Code of Judicial Procedure . Excess information is information that pertains to matters other than the investigation for which the secret measure of surveillance was used. The 2023 legislative amendment explicitly allows the information to be used for “other purposes” than the original i
When automating data analysis or broadcasts in association football, a key piece of information is the position of the football. Locating the ball is often easier said than done since there are many scenarios where the ball is hard or even impossible to detect accurately using object detection methods. This thesis explores a different approach to determining the ball's position. Since the play
To properly understand regions of space behind interstellar dust, like the Galactic bulge, infrared (IR) observations are needed, as it passes through the dust with minimal absorption. In the past few decades, the development of IR telescopes has allowed for a much deeper understanding of our Galaxy’s stellar populations and history. To properly use the data which these IR telescopes produce howev
Nearly all multicellular organisms reproduce sexually, whereas asexual reproduction is predominant in unicellular species. However, it is unclear why we see such a tight co-occurrence between multicellularity and sex. Here, we investigate the effect sexual reproduction has on the evolution of multicellularity in the green algae, Chlamydomonas reinhardtii, specifically on the variation and novel ph
Under senare år har det både i Sverige, Danmark och Norge förekommit ett stort antal fall där tilltalade invänt att de befunnit sig i somnambula tillstånd och därmed inte kan hållas straffrättsligt ansvariga för sina gärningar. Trots att de skandinaviska ländernas hantering av sömninvändningar görs utifrån olika rättsliga utgångspunkter, har de gemensamt att det vid bedömningen är fråga om subjekt
