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Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all-cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on
Pulmonary arterial hypertension (PAH) is a lethal condition where expansion of the vascular extracellular matrix contributes to increased pulmonary vascular resistance. Versican, a chondroitin sulfate proteoglycan, is known to accumulate in vascular lesions of PAH and hyaluronan and tenascin-C, binding partners of versican, are elevated in PAH. The specific distribution and localization of versica
Immediate-early genes of the fos and jun families encode proteins that dimerize to form a complex of activator protein 1 and regulate the expression of a number of genes in the nervous system. Ethanol has previously been shown to induce alterations in expression of fos and jun genes in the brain. The present study examined the effects of ethanol on the expression of c-fos, fosB, c-jun, junB and ju
AIMS: People with Type 1 diabetes have smaller pancreases than healthy individuals. Several diseases causing pancreatic atrophy are associated with pancreatic steatosis, but pancreatic fat in Type 1 diabetes has not been measured. This cross-sectional study aimed to compare pancreas size and fat fraction in children with Type 1 diabetes and controls.METHODS: The volume and fat fraction of the panc
PURPOSE: In the context of oncologic therapy for children, radiation therapy is frequently indicated. This study identified the frequency of and reasons for the development of high-grade acute toxicity and possible sequelae.MATERIALS AND METHODS: Irradiated children have been prospectively documented since 2001 in the Registry for the Evaluation of Side Effects After Radiation in Childhood and Ado
We present results of an eight-gene molecular study of the subfamily Acronictinae and related Noctuidae. Amphipyrinae are recovered as sister to Acronictinae, but with weak support - not surprisingly, the content of the two subfamilies has often been mixed in classifications. Balsinae, previously placed near Acronictinae or within Noctuinae, is recovered within an unresolved polytomy of Cuculliina
The title of this thesis is The Reading Machine. Aspects of Image and Book in the Works of Anders Billow 1923 – 1953. My aim is to revise and complement the historical understanding of the establishing of the modernistic “new typography” within the theory and practice of graphic design. A wider ambition is to, through example, better clarify the surrounding society’s influence on design and how ne
Exposure to vibrations from tools and machines used in construction work can induce damages to the human body. One of the most frequent symptoms is the hand-arm vibration syndrome commonly known as white fingers. The proportions of the international workforce exposed to vibrations are high and dominating sectors are construction, agriculture, forestry, and transport. Particularly exposed construct
Background: The clinical relevance of brain β-amyloidosis in older adults without dementia is not established. As delirium and dementia are strongly related, studies on patients with delirium may give pathophysiological clues. Objective: To determine whether the Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers amyloid-β 1-42 (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau) ar
Process-based models can be classified into: (a) terrestrial biogeochemical models (TBMs), which simulate fluxes of carbon, water and nitrogen coupled within terrestrial ecosystems, and (b) dynamic global vegetation models (DGVMs), which further couple these processes interactively with changes in slow ecosystem processes depending on resource competition, establishment, growth and mortality of di
The binding of factor IX to cultured bovine endothelial cells was characterized using isolated domains of bovine factor IX. An NH2-terminal fragment that consists of the gamma-carboxyglutamic acid (Gla) region linked to the two epidermal growth factor (EGF)-like domains bound to the endothelial cells with the same affinity as intact factor IX, indicating that the serine protease part of factor IX
In order to gain further insight into (i) the use of conditioned quantities for characterizing turbulence within a premixed flame brush and (ii) the influence of front propagation on turbulent scalar transport, a 3D Direct Numerical Simulation (DNS) study of an infinitely thin front that self-propagates in statistically stationary, homogeneous, isotropic, forced turbulence was performed by numeric
Detailed quantitative analysis of the vulnerability of different hippocampal and striatal neurons to global forebrain ischemia has not previously been performed. Here we have studied the survival of immunocytochemically identified neurons using an unbiased stereological method in rats subjected to global forebrain ischemia for 30 min and sacrificed 48 h, 1 week or 4 weeks thereafter. Within the hi
Chromosome banding analyses reveal secondary chromosome abnormalities in addition to the MYC translocations t(8;14)(q24;q32), t(8;22)(q24;q11), and t(2;8)(p11;q24) in 60%-80% of Burkitt lymphomas/leukemias (BL). The high incidence of such aberrations indicates that additional changes are important, perhaps necessary, for malignant transformation, i.e., the 8q24/MYC rearrangements may not be suffic
1. Ecological stoichiometry predicts important control of the relative abundance of the key elements carbon (C), nitrogen (N) and phosphorus (P) on trophic interactions. In a nutrient-poor Amazonian lowland rain forest of French Guiana, we tested the hypothesis that decomposers exploit stoichiometrically diverse plant litter more efficiently, resulting in faster litter decomposition compared to li
En pandemi är ett typexempel på force majeure: det är en genomgripande händelse för hela samhället. Så också för byggbranschen. Under våren 2020 drabbades många entreprenader av personalbrist och leveransproblem. Störningarna var dock kortvariga och den övergripande bilden är att byggbranschen klarat sig förhållandevis väl genom pandemin. En långsiktig förändring är kravet på smittskyddsgärder. SyA pandemic is a classic example of force majeure. In spring 2020, due to the corona virus, a lot of construction sites was affected by a lack of personal and delivery problem. The problems were however only temporary, and the overall picture is that the construction business has done relatively well during the pandemic. Something that is permanent is the requirement for prevention of infection at
We live in a world built on consumerist values and a spatial rationale of capital accumulation. This modern society has led to architecture thriving through super consumption and super production ultimately leading to the generic. Cities and spaces that were usually rich in variation and texture have now become an architectural melting pot. Architecture has become smooth, simplified and reduced to
I detta examensarbete undersöks databasen Plantfacts som innehåller data om stålverk från hela världen. Syftet med detta är att utvärdera om det finns en koppling mellan primärt och sekundärt producerat stål och olika typer av stålverk i downstream-processer. För att utföra detta har databasen formaterats om i Excel med hjälp av Visual Basic for Applications (VBA). Från början var Plantfacts databIn this thesis the Plantfacts database is investigated, which contains data about steel plants from all over the world. The purpose is to evaluate wheter there is a coupling between primary and secondary steel and different types of steel plants in downstream processes. To achieve this, the database has been reformatted using Visual Basic for Applications (VBA) in Excel. Initially, the Plantfacts
Då klimatfrågan blir större och viktigare än någonsin är det viktigt att alla olika aktörer tar sitt ansvar och aktivt arbetar för ett bättre klimat. Byggsektorn har ett stort ansvar i denna fråga och något som kan minska utsläppen är just att minska energibehovet i byggnader. Genom att reducera köldbryggorna minskas även andelen energi som behövs för att värma upp en byggnad. Det är dock inte endAs the climate issue becomes more significant and critical than ever, it is essential that all different actors assume their responsibilities and actively work for a better climate. The construction sector has a great responsibility on this issue, and something that can reduce emissions is to reduce energy consumption in buildings. By reducing the thermal bridges, the proportion of energy needed t
The conflict mineral crisis has been ongoing in the DRC for nearly two decades, with armed groups and increased military presence have played on the tin, tantalum, tungsten and gold to fund a brutal war across the eastern region of the country. Recent international efforts to tackle such illicit trade in conflict minerals has focused on requiring relevant stakeholders involved in the mineral sourc
