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Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma

Background: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. Objective: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma. Methods: This was a longitudinal, cohort study across 22 countries participating in the International Sever

Precise characterisation of HD 15337 with CHEOPS: A laboratory for planet formation and evolution

Context. The HD 15337 (TIC 120896927, TOI-402) system was observed by the Transiting Exoplanet Survey Satellite (TESS), revealing the presence of two short-period planets situated on opposite sides of the radius gap. This offers an excellent opportunity to study theories of formation and evolution, as well as to investigate internal composition and atmospheric evaporation. Aims. We aim to constrai

Nominal and verbal affixation in the Caucasus : A morphological and phonological approach

This thesis aims to investigate the interaction between complex morphology and complex phonology in the languages of the Caucasus. The Caucasus is well-known for containing languages with exceptionally large case systems and complex polysynthetic verbal morphology, which is paired with some of the largest consonant inventories in the world outside Africa. The study focuses specifically on nominal

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease

Accumulating evidence demonstrating higher cerebrospinal fluid (CSF) α-synuclein (αSyn) levels and αSyn pathology in the brains of Alzheimer's disease (AD) patients suggests that αSyn is involved in the pathophysiology of AD. To investigate whether αSyn could be related to specific aspects of the pathophysiology present in both sporadic and familial disease, we quantified CSF levels of αSyn and as

Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy

Background: Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus (GDM), but whether stretches of differentially methylated regions (DMRs) can also be identifi

A “practice” perspective in Logistics Management - A practice theory approach in a “two-case” case study in Greece

Keywords Practice, Practice theory, Supply chain and Logistics, Management, Logistics manager, Managerial work, Shadowing, “Two case” case study, Greece Thesis Purpose The aim of this thesis is to provide a deep insight into the logistics managers’ work practices as well as to introduce, apply and contribute in the development of a new theory in the service management domain, which is the practi

Barns rätt att ansöka om bistånd

Föreliggande uppsats är ett examensarbete på juris kandidatprogram. Avhandlingen behandlar de problem som aktualiseras när barn ansöker om bistånd med stöd av 4 kap. 1 §. Inledningsvis kommer jag att ge en kortfattad beskrivning av den sociala barn- och ungdomsvården, det utredningsarbete som förevarit i frågan om barns rätt att ansöka om bistånd samt de internationell principer som den svenska laThe following essay is written within the field of social law. As an introduction the thesis will presents the resent development within the child and youth care system, as well as the international regulations that Swedish legislation must comply with. I will also outline the responsibilities of the government to meet children´s needs for protection and support. Furthermore, the essay will presen

Genomic differentiation in small- and large-beaked Nesospiza finches

It was in the early 1980s when Peter Ryan from the University of Cape Town started investigating ecological and conservational factors surrounding the endemic Nesospiza finches in the Tristan da Cunha archipelago, a curious case of resource-driven bird diversification in the Southern Atlantic. Ryan and others suggests for the radiation of Tristan finches to have happened around 400,000 years ago,

Systematic observation in healthcare: Utility and limitations of a threat and error management-based safety audit

Improving teamwork has become a major safety goal for healthcare organizations. Audit tools currently available are useful, but they remain inadequate because they are reactive and fail to provide context for “the interaction between people and the operational context (i.e., organizational, regulatory and environmental factors) within which people discharge their operational duties” (Maurino, 2005

Sami Impact on Decision-making in Sweden - an analysis of present possibilities for participation and consultation in relation to international obligations

Den samiska ursprungsbefolkningens traditionella territorium breder ut sig över delar av Sverige, Norge, Finland och Ryssland. Samisk kultur är starkt kopplad till rennäringen, som kräver vidsträckta och sammanhängande marker där renen ostörd kan få tillgång till naturbete. Den här uppsatsen undersöker nuvarande möjligheter för samer i Sverige att påverka beslutsprocesser rörande användning av marThe traditional territory of the indigenous Sami people stretches into Sweden, Norway, Finland and Russia. Sami culture is strongly connected to reindeer husbandry, which requires vast and coherent land where the reindeer can access natural pasture without disturbances. This thesis examines present possibilities for Sami in Sweden to impact decision-making processes regarding use of land and natur

Företagsbesiktning – En analys av företagsbesiktningens rättsverkningar

Begreppet due diligence är i svenskt näringsliv synonymt med företagsbesiktning. Som företeelse är det en procedur för att genomlysa ett målbolags ekonomiska ställning och andra förhållanden. Företagsbesiktningen är således ett viktigt instrument för att skaffa sig kunskap om inneboende risker i målbolaget samt för att identifiera risker med förvärvet i stort. Besiktningen ger köparen ett bra beslThe concept of due diligence in the Swedish business sector is synonymous with "company inspection." It is legitimately a procedure for examining the financial position and other circumstances of a company. The company inspection is a significant instrument for acquiring knowledge of inherent risks in the offeree company, and for identifying risks with the acquisition in general. The con

Deep convolution neural network for attention decoding in multi-channel EEG with conditional variational autoencoder for data augmentation

Objectives: This project aims to develop a deep learning-based attention decoding system that can distinguish between noise and speech in noise and also identify the direction of attended speech from the brain data recorded with electroencephalography (EEG) instruments. Two deep convolutional neural network (DCNN) models will be designed: (1) one DCNN model capable of classifying incoming segments

Optimization of Solid-State Fermentation process for brown seaweed using LAB and characterization of the products

Fermentation has played a vital role in human history, offering solutions for food preservation, culinary diversity, and the creation of diverse and flavorful foods and beverages. Its importance continues today, both in traditional practices and in modern industrial applications. This report outlines the outcomes of an investigation into and the optimization of the solid-state fermentation proces

Towards a Geographic Information Systems and Data-Driven Integration Management.

Integration management in Finland and Tampere is broad task including multiple actors and departments. To manage integration, is to coordinate the cross organizational cooperation of multiple service structures that support migrants with different kinds of services. Although integration work has traditionally been provided through the Employment & growth services,the other relevant services fo

Role of Tumor Suppressor protein CSMD1 along with its effect on Trastuzumab treatment in HER-2 positive Breast adenocarcinoma and its regulation by miRNAs in Gliomas

Background: Cancer, which is known for its high mortality rate, can affect several tissue types. Among these, breast cancer is the most prevalent form worldwide and gliomas has one of the highest mortality rates among all cancer types. CSMD1 is a complement inhibitor with known tumor suppressor properties, whose down-regulation and deletion has been identified in several cancer types. In this stud

Möjligheten till blockuthyrning på bostadsmarknaden - Med fokus på bedömningen av behovsrekvisitet

Andrahandsuthyrning har under en längre tid funnits på bostadsmarknaden och varit en vanligt förekommande form av uthyrning. Utöver den klassiska andrahandsuthyrningen finns en annan form av uthyrning på bostadsmarknaden, uthyrning i form av blockuthyrning. Blockuthyrning som uthyrningsform har funnits på bostadsmarknaden under en tid men är trots detta en förhållandevis okänd företeelse för gemenSubletting has existed in the housing market for a long time and is a common form of rental. In addition to the common form of subletting, another form of rental is the blockrental agreement. This form of rental, has been used in the housing market for a while but is still relatively unknown to the general public. A blockrental agreement is an agreement involving at least three apartments under

Consumer Attitudes and Perceptions towards Environmental Impacts of Secondhand Clothing in Tanzania: "Mitumba "The Case of Tanzania

In Tanzania, there has been a notable increase in the importation and sale of secondhand clothing, popularly referred to as Mitumba, with a significant focus on low-income populations. This growth has been driven by the affordability and accessibility of these garments, which have become a staple in the wardrobes of many Tanzanians. However, with all of this growth, there are now urgent concerns a

Rättsliga förutsättningar för utvecklingen av vindkraft -En granskning av tillståndsprövningen enligt miljöbalken och plan- och bygglagen

Den svenska riksdagen har höga ambitioner om att utveckla den förnyelsebara energin i allmänhet och vindkraften i synnerhet. Nationella energi- och miljöpolitiska mål har antagits för att förenkla etableringar och således skapa förutsättningar för en utveckling av vindkraften i Sverige. Ambitionerna är högt ställda men politiska ställningstagande kräver verkställighet och resultatet av det finner The Swedish Parliament sets high ambitions in order to develop renewable energy in general and wind energy in particular. National energy and environmental policies have been adopted to facilitate wind power establishments and thus create conditions for development of wind power in Sweden. The ambitions are high but political positions requires enforcement and the result of the objectives are foun

UBER - Ren transportverksamhet eller elektronisk informationsförmedling?

I denna uppsats undersöks begreppet tjänst och vad som utgör en tjänst tillhörande informationssamhället samt en tjänst på transportområdet. Utredningen görs med anledning av att en spansk domare fattat beslut om att inhämta ett förhandsavgörande där EU-domstolen ska undersöka huruvida tjänsten Uber utgör en tjänst tillhörande informationssamhället eller istället utgör ren transportverksamhet. FThe main purpose of this thesis is to examine the notion of services and consider what constitutes an information society service and a service in the transport sector. In a preliminary ruling, yet to be decided by the European Court of Justice, a Spanish judge has recently queried whether the service provided by Uber should be considered an “information society service” or merely a transport serv

Hållbara städer ur ett systemperspektiv - en komplex verklighet i en svensk kontext

I och med de utmaningar som mänskligheten idag står inför, med stora klimatförändringar, ökad urbanisering och en global ekonomi kan städer komma att spela en central roll i hållbarhetsarbetet. Det är av vikt att beslutsfattare i städer kan förstå, hantera och styra på ett sätt att städerna utvecklas till hållbara samhällen med hållbara processer. Frågan är hur väl beslutsfattarnas sätt att hanterWith the challenges facing humanity today, with rapid climate changes, an increased urbanization and a global economy, cities can play a central role in sustainable development. It is important that decision-makers in the cities can understand, manage and govern in a way that cities develop into sustainable communities with sustainable processes. The question is how well the decision-makers' w