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In some ways, it can feel like conducting empirical research has become more and more difficult. Some standards that were widely agreed upon in the past for conducting research on gender and/or sex appear to be contested today (see Fraser, 2018). Some questions that may feel uncontroversial to ask for some research participants are a source of minority stress, exclusion, and outrage for others. Ca
Pedagogical development programmes (PDPs) are important for developing teaching skills for university teaching staff. Due to participants’ different teaching roles, their professional development needs and interests may also be different. However, little is known regarding the immediate needs of university teaching staff when they enter PDPs and how these may differ according to their roles. This
In vivo magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research and clinical diagnostics, allowing for non-invasive measurement and analysis of small molecules from living tissues. However, currently available MRS processing and analytical software tools are limited in their potential for in-depth quality management, access to details of the processing stream, and user fri
Accurate density matrix simulation of nuclear spin systems is critical for quantifying magnetic resonance spectroscopy (MRS) data, as well as for simulation studies designed to optimize acquisition parameters. Although a variety of packages exist to achieve this result, no currently available software is capable of computing a large number of spatial points in a reasonable time frame. Here we pres
Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by
Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio
The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina
The Cherenkov Telescope Array (CTA) is the future observatory for ground-based imaging atmospheric Cherenkov telescopes. Each telescope will provide a snapshot of gamma-ray induced particle showers by capturing the induced Cherenkov emission at ground level. The simulation of such events provides camera images that can be used as training data for convolutional neural networks (CNNs) to differenti
Dopaminergic neurons in the ventral midbrain are critical for regulating movement, cognition, and emotion. Ventral midbrain organoids can be used to model both development and diseases of the dopaminergic system, especially Parkinson’s disease. Here, we summarize recent advances and remaining challenges in developing such three-dimensional organoids from human pluripotent stem cells. We outline ho
This study investigates the neural encoding of speech features in hearing aid users using electroencephalography (EEG) during a simulated cocktail party scenario. The objective was to investigate neural tracking of various acoustic and linguistic features and how hearing aid noise reduction influenced this tracking. The features analyzed included the acoustic envelope, phonetic features, word onse
A numerical study has been carried out for slot jet impinging on flat and concave surfaces. Five turbulence models are employed for the predictions of these strongly strained turbulent flows, namely linear eddy viscosity model (LEVM), low-Re explicit algebraic Reynolds stress model (EASM) and three different V2F models. A bounded formulation for Cμ was also introduced to account for the better pre
A recent study of ours suggested that the very presence of a Teachable Agent (TA) from a mathematics learning game might affect students’ test performance when the TA reappeared in the margin of a regular, digital math test. We hypothesized that this effect, which seemed to particularly target low-achievers, was due to the students’ mindset changing from that of “taking a test” to that of “teachin
Decisions regarding strategic software process improvement (SPI) are generally based on the management's viewpoint of the situation, and in some cases also the viewpoints of some kind of an SPI group. This may result in strategies, which are not accepted throughout the organisation, as the views of how the process is functioning are different throughout the company. This paper describes a method f
Controlling an induction machine has been a difficult task since its invention, especially at low speed operation and during highly dynamic regimes, where the required torque/speed changes constantly. This paper aims to present the validation and implementation of a deadbeat direct torque and flux control scheme (DB-DTFC) for induction machines on a multilevel platform consisting on an FPGA, a rea
