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Popular Abstract in Swedish Forskning kring biomarkörer har revolutionerat cancersjukvården. Några av de mest kända exemplen är PSA-testet som kan användas för att identifiera patienter med ökad risk för prostata cancer eller de nya antikroppsbehandlingarna, t.ex mot HER2 (trastuzumab/Hercepin) eller CD20 (rituximab/Rituxan), som gör att man nu ofta kan förlänga eller bota patienter som tidigare hThe goal of biomarker discovery is to identify disease defining molecules, which could be used to improve early detection and/or to predict survival and response to treatment. This thesis is about the transcription factor SOX11, a protein discovered in the context of mantle cell lymphoma in 2008, which shows great potential to be used as a clinical relevant biomarker. The aim of this thesis is to

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We report on preliminary results from time-resolved optical spectroscopy of the He-rich variable white dwarf GD 358.

We present the characterization results of a new high resolution negative electron beam resist mr-L 6000.1 XP. The resist can also be used as imprintable polymer in nanoimprint lithography with sub-100 nm resolution. The feature size achieved after e-beam exposure was about 50 nm with sensitivity of 2-4 μC/cm². Studies of the resist properties as a function of chemical composition and d

Automating the synthesis of operating procedures for batch processes is very valuable as plant personnel often spend considerable amount of time and effort in preparing and verifying them for correctness and completeness. Towards this goal, a framework for automating operating procedure synthesis for batch processes is proposed in this paper. We propose an approach based on Grafcet, a discrete eve

In this thesis, methodology of radiolabeling and simultaneous biotinylation for internalizing monoclonal antibody (MAb) chimeric BR96 (chiBR96) have been investigated by using three element groups of potential therapeutic radionuclides iodine, indium and rhenium, and their different labeling methods. The biodistribution and kinetics of biotinylated and radiolabeled chiBR96 have been studied in col

A combustion system was developed to burn a low value gas in the VT4400 IGT engine demonstrator. The combustor was designed in an engine configuration consisting of a single LCV combustor operating in combination with six LP combustors.

Popular Abstract in Swedish Efter terroristattackerna den 11 september 2001 har FN:s säkerhetsråd - med USA i spetsen - radikalt utvidgat sina egna befogenheter när det gäller att upprätthålla internationell fred och säkerhet genom att anta resolutioner som i praktiken är lagstiftande. Resolution 1373 (som behandlar terrorism) och resolution 1540 (som behandlar spridning av massförstörelsevapen tiSince the end of the Cold War, international politics and international law have not only become increasingly intertwined, but their mutual implications have also become increasingly recognized by scholars. Yet research explicitly addressing the question of how political factors affect the emergence of legal rules is still limited. This doctoral dissertation aims to take a step in the direction of

Applying contemporary ideas regarding the role literature may have had in human evolutionary history to literary analysis, using Herman Melville's Moby Dick as a case study. The paper focuses on the function of male bonding in the text, the ways in which the setting is defined by humanity's evolutionary past, and the artistic function of the hunt, as it is described in the text.

Genom osteohistologiska analyser kan stora mängder information erhållas. Förutom möjligheten att uppskatta åldern och mognadsgraden hos ett djur kan tillväxtsmärken i skelettet, så kallade ’growth marks’ eller GM, också innehålla information om benens tillväxtshastighet, djurets tillväxtstrategi och till och med levnadssätt. Denna studie avhandlar histologin hos fossiliserade ben tillhörande en haOsteo-histology provides information on age, growth strategies, and lifestyles of both recent and ancient animals. This study deals with the histology of fossilized bone from three groups of tetrapods – sea turtles, ichthyosaurs and plesiosaurs – all secondarily adapted to marine life, but with rather different bone microstructures. As a result of extensive vascularization (i.e. osteoporosis), ich

Until recently, the general level of detail in full car crash models has not allowed a physical modeling of rubber bushings with solid elements. This is partly because of the difficulty in modeling the complex characteristic of rubber, but also due to limited understanding of the mechanical properties of rubber materials. The main focus of this Master’s thesis project is to develop a new and im

We present a dual-wavelength polarimetric measurement method to distinguish species and sexes of disease transmitting mosquitoes in flight. By measuring co- and de-polarized backscattered light at 808 and 1550nm, the degree of linear polarization, wingbeat frequency, reflectance, spectral ratio and glossiness of mosquitoes can be retrieved. Body and wing contributions to these signals can be separ